These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 16606821)

  • 21. Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.
    Huber MD; Vesely PW; Datta K; Gerace L
    J Cell Biol; 2013 Nov; 203(3):427-36. PubMed ID: 24217618
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles.
    Adams CM; Goldstein JL; Brown MS
    Proc Natl Acad Sci U S A; 2003 Sep; 100(19):10647-52. PubMed ID: 12963821
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Retrospective on Cholesterol Homeostasis: The Central Role of Scap.
    Brown MS; Radhakrishnan A; Goldstein JL
    Annu Rev Biochem; 2018 Jun; 87():783-807. PubMed ID: 28841344
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells.
    Lee PC; Liu P; Li WP; Debose-Boyd RA
    J Lipid Res; 2007 Sep; 48(9):1944-54. PubMed ID: 17586788
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver.
    Hwang S; Nguyen AD; Jo Y; Engelking LJ; Brugarolas J; DeBose-Boyd RA
    J Biol Chem; 2017 Jun; 292(22):9382-9393. PubMed ID: 28416613
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins.
    Sun LP; Seemann J; Goldstein JL; Brown MS
    Proc Natl Acad Sci U S A; 2007 Apr; 104(16):6519-26. PubMed ID: 17428919
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.
    Lee JN; Gong Y; Zhang X; Ye J
    Proc Natl Acad Sci U S A; 2006 Mar; 103(13):4958-63. PubMed ID: 16549805
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.
    Faulkner RA; Nguyen AD; Jo Y; DeBose-Boyd RA
    J Lipid Res; 2013 Apr; 54(4):1011-22. PubMed ID: 23403031
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes.
    Rodrigue-Way A; Caron V; Bilodeau S; Keil S; Hassan M; Lévy E; Mitchell GA; Tremblay A
    FASEB J; 2014 Apr; 28(4):1910-23. PubMed ID: 24371122
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.
    Yabe D; Xia ZP; Adams CM; Rawson RB
    Proc Natl Acad Sci U S A; 2002 Dec; 99(26):16672-7. PubMed ID: 12482938
    [TBL] [Abstract][Full Text] [Related]  

  • 31. The role of cholesterol binding in the control of cholesterol by the Scap-Insig system.
    Lee AG
    Eur Biophys J; 2022 Jul; 51(4-5):385-399. PubMed ID: 35717507
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi.
    Zhang Y; Motamed M; Seemann J; Brown MS; Goldstein JL
    J Biol Chem; 2013 May; 288(20):14059-14067. PubMed ID: 23564452
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.
    Jo Y; Hartman IZ; DeBose-Boyd RA
    Mol Biol Cell; 2013 Feb; 24(3):169-83. PubMed ID: 23223569
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
    Jo Y; Lee PC; Sguigna PV; DeBose-Boyd RA
    Proc Natl Acad Sci U S A; 2011 Dec; 108(51):20503-8. PubMed ID: 22143767
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Phosphorylation of Insig-2 mediates inhibition of fatty acid synthesis by polyunsaturated fatty acids.
    Tian J; Goldstein JL; Li S; Schumacher MM; Brown MS
    Proc Natl Acad Sci U S A; 2024 Aug; 121(34):e2409262121. PubMed ID: 39145929
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.
    DeBose-Boyd RA
    Cell Res; 2008 Jun; 18(6):609-21. PubMed ID: 18504457
    [TBL] [Abstract][Full Text] [Related]  

  • 37. [Disorder of cholesterol metabolism: regulation of intracellular cholesterol and membrane trafficking].
    Tamasawa N
    Rinsho Byori; 2010 Dec; 58(12):1203-10. PubMed ID: 21348240
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Sirolimus inhibits endogenous cholesterol synthesis induced by inflammatory stress in human vascular smooth muscle cells.
    Ma KL; Varghese Z; Ku Y; Powis SH; Chen Y; Moorhead JF; Ruan XZ
    Am J Physiol Heart Circ Physiol; 2010 Jun; 298(6):H1646-51. PubMed ID: 20348217
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.
    Yabe D; Komuro R; Liang G; Goldstein JL; Brown MS
    Proc Natl Acad Sci U S A; 2003 Mar; 100(6):3155-60. PubMed ID: 12624180
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.
    Burg JS; Powell DW; Chai R; Hughes AL; Link AJ; Espenshade PJ
    Cell Metab; 2008 Dec; 8(6):522-31. PubMed ID: 19041767
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.