These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 16621528)

  • 1. Carboxylate bioisosteres of pregabalin.
    Schwarz JB; Colbry NL; Zhu Z; Nichelson B; Barta NS; Lin K; Hudack RA; Gibbons SE; Galatsis P; DeOrazio RJ; Manning DD; Vartanian MG; Kinsora JJ; Lotarski SM; Li Z; Dickerson MR; El-Kattan A; Thorpe AJ; Donevan SD; Taylor CP; Wustrow DJ
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3559-63. PubMed ID: 16621528
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Carboxylate bioisosteres of gabapentin.
    Burgos-Lepley CE; Thompson LR; Kneen CO; Osborne SA; Bryans JS; Capiris T; Suman-Chauhan N; Dooley DJ; Donovan CM; Field MJ; Vartanian MG; Kinsora JJ; Lotarski SM; El-Kattan A; Walters K; Cherukury M; Taylor CP; Wustrow DJ; Schwarz JB
    Bioorg Med Chem Lett; 2006 May; 16(9):2333-6. PubMed ID: 15946842
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein.
    Schwarz JB; Gibbons SE; Graham SR; Colbry NL; Guzzo PR; Le VD; Vartanian MG; Kinsora JJ; Lotarski SM; Li Z; Dickerson MR; Su TZ; Weber ML; El-Kattan A; Thorpe AJ; Donevan SD; Taylor CP; Wustrow DJ
    J Med Chem; 2005 Apr; 48(8):3026-35. PubMed ID: 15828841
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Heteroaromatic side-chain analogs of pregabalin.
    Schelkun RM; Yuen PW; Wustrow DJ; Kinsora J; Su TZ; Vartanian MG
    Bioorg Med Chem Lett; 2006 May; 16(9):2329-32. PubMed ID: 16099652
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein.
    Belliotti TR; Capiris T; Ekhato IV; Kinsora JJ; Field MJ; Heffner TG; Meltzer LT; Schwarz JB; Taylor CP; Thorpe AJ; Vartanian MG; Wise LD; Zhi-Su T; Weber ML; Wustrow DJ
    J Med Chem; 2005 Apr; 48(7):2294-307. PubMed ID: 15801823
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin.
    Zoidis G; Papanastasiou I; Dotsikas I; Sandoval A; Dos Santos RG; Papadopoulou-Daifoti Z; Vamvakides A; Kolocouris N; Felix R
    Bioorg Med Chem; 2005 Apr; 13(8):2791-8. PubMed ID: 15781390
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ca2+ channel alpha2-delta ligands for the treatment of neuropathic pain.
    Field MJ; Li Z; Schwarz JB
    J Med Chem; 2007 May; 50(11):2569-75. PubMed ID: 17489571
    [No Abstract]   [Full Text] [Related]  

  • 8. Synthesis and in vivo evaluation of 3-substituted gababutins.
    Blakemore DC; Bryans JS; Carnell P; Chessum NE; Field MJ; Kinsella N; Kinsora JK; Osborne SA; Williams SC
    Bioorg Med Chem Lett; 2010 Jan; 20(1):362-5. PubMed ID: 19897364
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.
    Taylor CP; Angelotti T; Fauman E
    Epilepsy Res; 2007 Feb; 73(2):137-50. PubMed ID: 17126531
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis, and preliminary evaluation of gabapentin-pregabalin mutual prodrugs in relieving neuropathic pain.
    Shi W; Liu H; Zhang Y; Zhong B; Yang H
    Arch Pharm (Weinheim); 2005 Aug; 338(8):358-64. PubMed ID: 16041834
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury.
    Hong-Ju Y; He L; Wei-Guo S; Nan Z; Wei-Xiu Y; Zhong-Wei J; Jun-Wei W; Zheng-Hua G; Bo-Hua Z; Zhi-Pu L; Zhe-Hui G
    Bioorg Med Chem Lett; 2004 May; 14(10):2537-41. PubMed ID: 15109646
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.
    Blakemore DC; Bryans JS; Carnell P; Field MJ; Kinsella N; Kinsora JK; Meltzer LT; Osborne SA; Thompson LR; Williams SC
    Bioorg Med Chem Lett; 2010 Jan; 20(1):248-51. PubMed ID: 19910190
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and in vivo evaluation of bicyclic gababutins.
    Blakemore DC; Bryans JS; Carnell P; Carr CL; Chessum NE; Field MJ; Kinsella N; Osborne SA; Warren AN; Williams SC
    Bioorg Med Chem Lett; 2010 Jan; 20(2):461-4. PubMed ID: 20005103
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: design, synthesis, and biological activity.
    Yuan H; Silverman RB
    Bioorg Med Chem; 2006 Mar; 14(5):1331-8. PubMed ID: 16263300
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target.
    Thorpe AJ; Offord J
    Curr Opin Investig Drugs; 2010 Jul; 11(7):761-70. PubMed ID: 20571971
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The mechanisms of action of gabapentin and pregabalin.
    Sills GJ
    Curr Opin Pharmacol; 2006 Feb; 6(1):108-13. PubMed ID: 16376147
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents.
    Bryans JS; Davies N; Gee NS; Dissanayake VU; Ratcliffe GS; Horwell DC; Kneen CO; Morrell AI; Oles RJ; O'Toole JC; Perkins GM; Singh L; Suman-Chauhan N; O'Neill JA
    J Med Chem; 1998 May; 41(11):1838-45. PubMed ID: 9599234
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro.
    Cunningham MO; Woodhall GL; Thompson SE; Dooley DJ; Jones RS
    Eur J Neurosci; 2004 Sep; 20(6):1566-76. PubMed ID: 15355323
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A new enantioselective synthesis of the anticonvulsant drug pregabalin (Lyrica) based on a hydrolytic kinetic resolution method.
    Mujahid M; Muthukrishnan M
    Chirality; 2013 Dec; 25(12):965-9. PubMed ID: 24151098
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Decarbonylative radical coupling of α-aminoacyl tellurides: single-step preparation of γ-amino and α,β-diamino acids and rapid synthesis of gabapentin and manzacidin A.
    Nagatomo M; Nishiyama H; Fujino H; Inoue M
    Angew Chem Int Ed Engl; 2015 Jan; 54(5):1537-41. PubMed ID: 25504989
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.