257 related articles for article (PubMed ID: 16630891)
1. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Rodriguez-Viciana P; Oses-Prieto J; Burlingame A; Fried M; McCormick F
Mol Cell; 2006 Apr; 22(2):217-30. PubMed ID: 16630891
[TBL] [Abstract][Full Text] [Related]
2. SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.
Young LC; Hartig N; Boned Del Río I; Sari S; Ringham-Terry B; Wainwright JR; Jones GG; McCormick F; Rodriguez-Viciana P
Proc Natl Acad Sci U S A; 2018 Nov; 115(45):E10576-E10585. PubMed ID: 30348783
[TBL] [Abstract][Full Text] [Related]
3. Structural insights into the role of SHOC2-MRAS-PP1C complex in RAF activation.
Bonsor DA; Simanshu DK
FEBS J; 2023 Oct; 290(20):4852-4863. PubMed ID: 37074066
[TBL] [Abstract][Full Text] [Related]
4. Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Hauseman ZJ; Fodor M; Dhembi A; Viscomi J; Egli D; Bleu M; Katz S; Park E; Jang DM; Porter KA; Meili F; Guo H; Kerr G; Mollé S; Velez-Vega C; Beyer KS; Galli GG; Maira SM; Stams T; Clark K; Eck MJ; Tordella L; Thoma CR; King DA
Nature; 2022 Sep; 609(7926):416-423. PubMed ID: 35830882
[TBL] [Abstract][Full Text] [Related]
5. Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Bonsor DA; Alexander P; Snead K; Hartig N; Drew M; Messing S; Finci LI; Nissley DV; McCormick F; Esposito D; Rodriguez-Viciana P; Stephen AG; Simanshu DK
Nat Struct Mol Biol; 2022 Oct; 29(10):966-977. PubMed ID: 36175670
[TBL] [Abstract][Full Text] [Related]
6. Structural basis for SHOC2 modulation of RAS signalling.
Liau NPD; Johnson MC; Izadi S; Gerosa L; Hammel M; Bruning JM; Wendorff TJ; Phung W; Hymowitz SG; Sudhamsu J
Nature; 2022 Sep; 609(7926):400-407. PubMed ID: 35768504
[TBL] [Abstract][Full Text] [Related]
7. The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.
Matsunaga-Udagawa R; Fujita Y; Yoshiki S; Terai K; Kamioka Y; Kiyokawa E; Yugi K; Aoki K; Matsuda M
J Biol Chem; 2010 Mar; 285(10):7818-26. PubMed ID: 20051520
[TBL] [Abstract][Full Text] [Related]
8. Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate.
Rodriguez-Viciana P; Sabatier C; McCormick F
Mol Cell Biol; 2004 Jun; 24(11):4943-54. PubMed ID: 15143186
[TBL] [Abstract][Full Text] [Related]
9. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Sasaki A; Taketomi T; Kato R; Saeki K; Nonami A; Sasaki M; Kuriyama M; Saito N; Shibuya M; Yoshimura A
Nat Cell Biol; 2003 May; 5(5):427-32. PubMed ID: 12717443
[TBL] [Abstract][Full Text] [Related]
10. Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling.
Kaduwal S; Jeong WJ; Park JC; Lee KH; Lee YM; Jeon SH; Lim YB; Min do S; Choi KY
Oncotarget; 2015 Oct; 6(32):33091-105. PubMed ID: 26384305
[TBL] [Abstract][Full Text] [Related]
11. Shoc2/Sur8 protein regulates neurite outgrowth.
Leon G; Sanchez-Ruiloba L; Perez-Rodriguez A; Gragera T; Martinez N; Hernandez S; Anta B; Calero O; Garcia-Dominguez CA; Dura LM; Peña-Jimenez D; Castro J; Zarich N; Sanchez-Gomez P; Calero M; Iglesias T; Oliva JL; Rojas JM
PLoS One; 2014; 9(12):e114837. PubMed ID: 25514808
[TBL] [Abstract][Full Text] [Related]
12. Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions.
Jaumot M; Hancock JF
Oncogene; 2001 Jul; 20(30):3949-58. PubMed ID: 11494123
[TBL] [Abstract][Full Text] [Related]
13. SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics.
Boned Del Río I; Young LC; Sari S; Jones GG; Ringham-Terry B; Hartig N; Rejnowicz E; Lei W; Bhamra A; Surinova S; Rodriguez-Viciana P
Proc Natl Acad Sci U S A; 2019 Jul; 116(27):13330-13339. PubMed ID: 31213532
[TBL] [Abstract][Full Text] [Related]
14. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Kwon JJ; Hajian B; Bian Y; Young LC; Amor AJ; Fuller JR; Fraley CV; Sykes AM; So J; Pan J; Baker L; Lee SJ; Wheeler DB; Mayhew DL; Persky NS; Yang X; Root DE; Barsotti AM; Stamford AW; Perry CK; Burgin A; McCormick F; Lemke CT; Hahn WC; Aguirre AJ
Nature; 2022 Sep; 609(7926):408-415. PubMed ID: 35831509
[TBL] [Abstract][Full Text] [Related]
15. Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo.
Mitsuhashi S; Shima H; Tanuma N; Matsuura N; Takekawa M; Urano T; Kataoka T; Ubukata M; Kikuchi K
J Biol Chem; 2003 Jan; 278(1):82-8. PubMed ID: 12374792
[TBL] [Abstract][Full Text] [Related]
16. Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.
Dai P; Xiong WC; Mei L
J Biol Chem; 2006 Jan; 281(2):927-33. PubMed ID: 16301319
[TBL] [Abstract][Full Text] [Related]
17. Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites.
Ory S; Zhou M; Conrads TP; Veenstra TD; Morrison DK
Curr Biol; 2003 Aug; 13(16):1356-64. PubMed ID: 12932319
[TBL] [Abstract][Full Text] [Related]
18. Structure of SHOC2-PP1C-RAS Reveals a Mechanism of RAF Activation.
Cancer Discov; 2022 Sep; 12(9):OF1. PubMed ID: 35838404
[TBL] [Abstract][Full Text] [Related]
19. SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers.
Jones GG; Del Río IB; Sari S; Sekerim A; Young LC; Hartig N; Areso Zubiaur I; El-Bahrawy MA; Hynds RE; Lei W; Molina-Arcas M; Downward J; Rodriguez-Viciana P
Nat Commun; 2019 Jun; 10(1):2532. PubMed ID: 31182717
[TBL] [Abstract][Full Text] [Related]
20. Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways.
Garcia J; de Gunzburg J; Eychène A; Gisselbrecht S; Porteu F
Mol Cell Biol; 2001 Apr; 21(8):2659-70. PubMed ID: 11283246
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
