BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

71 related articles for article (PubMed ID: 16631344)

  • 1. A novel RNAi library based on partially randomized consensus sequences of nuclear receptors: identifying the receptors involved in amyloid beta degradation.
    Yang JP; Fan W; Rogers C; Chatterton JE; Bliesath J; Liu G; Ke N; Wang CY; Rhoades K; Wong-Staal F; Li QX
    Genomics; 2006 Sep; 88(3):282-92. PubMed ID: 16631344
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A plasmid-based system for expressing small interfering RNA libraries in mammalian cells.
    Kaykas A; Moon RT
    BMC Cell Biol; 2004 Apr; 5():16. PubMed ID: 15119963
    [TBL] [Abstract][Full Text] [Related]  

  • 3. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
    Majercak J; Ray WJ; Espeseth A; Simon A; Shi XP; Wolffe C; Getty K; Marine S; Stec E; Ferrer M; Strulovici B; Bartz S; Gates A; Xu M; Huang Q; Ma L; Shughrue P; Burchard J; Colussi D; Pietrak B; Kahana J; Beher D; Rosahl T; Shearman M; Hazuda D; Sachs AB; Koblan KS; Seabrook GR; Stone DJ
    Proc Natl Acad Sci U S A; 2006 Nov; 103(47):17967-72. PubMed ID: 17098871
    [TBL] [Abstract][Full Text] [Related]  

  • 4. High-throughput screening of effective siRNAs from RNAi libraries delivered via bacterial invasion.
    Zhao HF; L'Abbé D; Jolicoeur N; Wu M; Li Z; Yu Z; Shen SH
    Nat Methods; 2005 Dec; 2(12):967-73. PubMed ID: 16299483
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.
    Wang PL; Niidome T; Akaike A; Kihara T; Sugimoto H
    J Neurosci Res; 2009 Jul; 87(9):2105-14. PubMed ID: 19267423
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibiting gene expression of alpha3 nicotinic receptor in SH-SY5Y cells with the effects on APP metabolism and antioxidation in Alzheimer's disease.
    Tang Z; An Y; Qi XL; Xiao Y; Shan KR; Guan ZZ
    Neurochem Int; 2008 Nov; 53(5):112-7. PubMed ID: 18647633
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effective inhibition of hepatitis B virus replication by small interfering RNAs expressed from human foamy virus vectors.
    Sun Y; Li Z; Li L; Li J; Liu X; Li W
    Int J Mol Med; 2007 Apr; 19(4):705-11. PubMed ID: 17334648
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selection and validation of optimal siRNA target sites for RNAi-mediated gene silencing.
    Luo Q; Kang Q; Song WX; Luu HH; Luo X; An N; Luo J; Deng ZL; Jiang W; Yin H; Chen J; Sharff KA; Tang N; Bennett E; Haydon RC; He TC
    Gene; 2007 Jun; 395(1-2):160-9. PubMed ID: 17449199
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
    Imbimbo BP; Del Giudice E; Colavito D; D'Arrigo A; Dalle Carbonare M; Villetti G; Facchinetti F; Volta R; Pietrini V; Baroc MF; Serneels L; De Strooper B; Leon A
    J Pharmacol Exp Ther; 2007 Dec; 323(3):822-30. PubMed ID: 17895400
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Gamma-secretase: a complex target for Alzheimer's disease.
    Lundkvist J; Näslund J
    Curr Opin Pharmacol; 2007 Feb; 7(1):112-8. PubMed ID: 17169612
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.
    Morgan-Lappe SE; Tucker LA; Huang X; Zhang Q; Sarthy AV; Zakula D; Vernetti L; Schurdak M; Wang J; Fesik SW
    Cancer Res; 2007 May; 67(9):4390-8. PubMed ID: 17483353
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of peptides derived from BACE1 catalytic domain on APP processing.
    Yeon SW; Jeon YJ; Hwang EM; Kim TY
    Peptides; 2007 Apr; 28(4):838-44. PubMed ID: 17293005
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Promoting alpha-secretase cleavage of beta-amyloid with engineered proteolytic antibody fragments.
    Kasturirangan S; Brune D; Sierks M
    Biotechnol Prog; 2009; 25(4):1054-63. PubMed ID: 19572401
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Genome-wide sreening by using small-interfering RNA expression libraries.
    Matsumoto S; Miyagishi M; Taira K
    Methods Mol Biol; 2007; 360():131-42. PubMed ID: 17172728
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
    Na CH; Jeon SH; Zhang G; Olson GL; Chae CB
    J Neurochem; 2007 Jun; 101(6):1583-95. PubMed ID: 17542811
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.
    Ni Y; Zhao X; Bao G; Zou L; Teng L; Wang Z; Song M; Xiong J; Bai Y; Pei G
    Nat Med; 2006 Dec; 12(12):1390-6. PubMed ID: 17115048
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
    Abramowski D; Wiederhold KH; Furrer U; Jaton AL; Neuenschwander A; Runser MJ; Danner S; Reichwald J; Ammaturo D; Staab D; Stoeckli M; Rueeger H; Neumann U; Staufenbiel M
    J Pharmacol Exp Ther; 2008 Nov; 327(2):411-24. PubMed ID: 18687920
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.