BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 16633564)

  • 1. The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine.
    Hornillo-Araujo AR; Burrell AJ; Aiertza MK; Shibata T; Hammond DM; Edmont D; Adams H; Margison GP; Williams DM
    Org Biomol Chem; 2006 May; 4(9):1723-9. PubMed ID: 16633564
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.
    Hornillo-Araujo AR; Burrell AJ; Aiertza MK; Shibata T; Hammond DM; Edmont D; Adams H; Margison GP; Williams DM
    Nucleosides Nucleotides Nucleic Acids; 2007; 26(8-9):1099-102. PubMed ID: 18058544
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The syntheses of tricyclic analogues of O6-methylguanine.
    Hammond DM; Edmont D; Hornillo-Araujo AR; Williams DM
    Org Biomol Chem; 2003 Dec; 1(23):4166-72. PubMed ID: 14685320
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase.
    Spratt TE; Wu JD; Levy DE; Kanugula S; Pegg AE
    Biochemistry; 1999 May; 38(21):6801-6. PubMed ID: 10346901
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase.
    Hazra TK; Roy R; Biswas T; Grabowski DT; Pegg AE; Mitra S
    Biochemistry; 1997 May; 36(19):5769-76. PubMed ID: 9153417
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.
    Yarosh DB; Hurst-Calderone S; Babich MA; Day RS
    Cancer Res; 1986 Apr; 46(4 Pt 1):1663-8. PubMed ID: 3948156
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Factors influencing the repair of the mutagenic lesion O6-methylguanine in DNA by human O6-methylguanine-DNA methyltransferase.
    Liem LK; Wong CW; Lim A; Li BF
    J Mol Biol; 1993 Jun; 231(4):950-9. PubMed ID: 8515475
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of human O6-methylguanine-DNA methyltransferase by 5-methylcytosine.
    Bentivegna SS; Bresnick E
    Cancer Res; 1994 Jan; 54(2):327-9. PubMed ID: 8275462
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors as potential tools for in vivo MGMT imaging.
    Mühlhausen U; Schirrmacher R; Piel M; Lecher B; Briegert M; Piee-Staffa A; Kaina B; Rösch F
    J Med Chem; 2006 Jan; 49(1):263-72. PubMed ID: 16392811
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2'-deoxyguanosine and their recognition by MGMT and Atl1.
    Abdu K; Aiertza MK; Wilkinson OJ; Grasby JA; Senthong P; Povey AC; Margison GP; Williams DM
    Chem Commun (Camb); 2012 Nov; 48(91):11214-6. PubMed ID: 23059787
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A new and efficient synthesis of pyrrolo[2,3-d]pyrimidine anticancer agents: Alimta (LY231514, MTA), homo-Alimta, TNP-351, and some aryl 5-substituted pyrrolo[2,3-d]pyrimidines.
    Taylor EC; Liu B
    J Org Chem; 2003 Dec; 68(26):9938-47. PubMed ID: 14682686
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Substrate specificity of human O6-methylguanine-DNA methyltransferase for O6-benzylguanine derivatives in oligodeoxynucleotides.
    Terashima I; Kawate H; Sakumi K; Sekiguchi M; Kohda K
    Chem Res Toxicol; 1997 Nov; 10(11):1234-9. PubMed ID: 9403175
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel synthesis, properties, and NAD+-NADH type redox ability of 1,3-dimethylcyclohepta[4,5]pyrrolo[2,3-d]pyrimidine- 2,4(1,3h)-dionylium ions annulated with additional pyrrolo[2,3-d]pyrimidine-1,3(2,4h)-dione and furan analogue, and their hydride adducts.
    Naya S; Nishimura J; Nitta M
    J Org Chem; 2005 Nov; 70(24):9780-8. PubMed ID: 16292806
    [TBL] [Abstract][Full Text] [Related]  

  • 14. An O6-methylguanine-DNA methyltransferase-like protein from Thermus thermophilus interacts with a nucleotide excision repair protein.
    Morita R; Nakagawa N; Kuramitsu S; Masui R
    J Biochem; 2008 Aug; 144(2):267-77. PubMed ID: 18483064
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of
    Abdu K; Aiertza MK; Wilkinson OJ; Senthong P; Craggs TD; Povey AC; Margison GP; Williams DM
    Nucleosides Nucleotides Nucleic Acids; 2020; 39(8):1108-1121. PubMed ID: 32449465
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).
    Arris CE; Bleasdale C; Calvert AH; Curtin NJ; Dalby C; Golding BT; Griffin RJ; Lunn JM; Major GN; Newell DR
    Anticancer Drug Des; 1994 Oct; 9(5):401-8. PubMed ID: 7945724
    [No Abstract]   [Full Text] [Related]  

  • 17. Reaction of O6-alkylguanine-DNA alkyltransferase with O6-methylguanine analogues: evidence that the oxygen of O6-methylguanine is protonated by the protein to effect methyl transfer.
    Spratt TE; de los Santos H
    Biochemistry; 1992 Apr; 31(14):3688-94. PubMed ID: 1314648
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine-DNA alkyltransferase: implications for the design of DNA-modifying drugs.
    Pletsas D; Wheelhouse RT; Pletsa V; Nicolaou A; Jenkins TC; Bibby MC; Kyrtopoulos SA
    Eur J Med Chem; 2006 Mar; 41(3):330-9. PubMed ID: 16458393
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT).
    Shibata T; Glynn N; McMurry TB; McElhinney RS; Margison GP; Williams DM
    Nucleic Acids Res; 2006; 34(6):1884-91. PubMed ID: 16609128
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Demethylation of O6-methylguanine in DNA by O6-methylguanine-DNA methyltransferase: synthesis and characterization of O6,9-dimethylguanine coordinated with cis-platin at the N7-position.
    Terashima I; Yamagata Y; Yamagami N; Kohda K
    Chem Pharm Bull (Tokyo); 1994 Apr; 42(4):903-6. PubMed ID: 8020126
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.