These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

151 related articles for article (PubMed ID: 16650763)

  • 21. 4-{(2R)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist--design, synthesis, and characterization.
    Chen C; Pontillo J; Fleck BA; Gao Y; Wen J; Tran JA; Tucci FC; Marinkovic D; Foster AC; Saunders J
    J Med Chem; 2004 Dec; 47(27):6821-30. PubMed ID: 15615531
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.
    Tran JA; Tucci FC; Arellano M; Jiang W; Chen CW; Marinkovic D; Fleck BA; Wen J; Foster AC; Chen C
    Bioorg Med Chem Lett; 2008 Mar; 18(6):1931-8. PubMed ID: 18294847
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Privileged structure-based ligands for melanocortin receptors-tetrahydroquinolines, indoles, and aminotetralines.
    Fisher MJ; Backer RT; Husain S; Hsiung HM; Mullaney JT; O'Brian TP; Ornstein PL; Rothhaar RR; Zgombick JM; Briner K
    Bioorg Med Chem Lett; 2005 Oct; 15(20):4459-62. PubMed ID: 16112861
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.
    Tian X; Switzer AG; Derose SA; Mishra RK; Solinsky MG; Mumin RN; Ebetino FH; Jayasinghe LR; Webster ME; Colson AO; Crossdoersen D; Pinney BB; Farmer JA; Dowty ME; Obringer CM; Cruze CA; Burklow ML; Suchanek PM; Dong L; Dirr MK; Sheldon RJ; Wos JA
    J Med Chem; 2008 Oct; 51(19):6055-66. PubMed ID: 18771254
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines.
    Tucci FC; White NS; Markison S; Joppa M; Tran JA; Fleck BA; Madan A; Dyck BP; Parker J; Pontillo J; Arellano LM; Marinkovic D; Jiang W; Chen CW; Gogas KR; Goodfellow VS; Saunders J; Foster AC; Chen C
    Bioorg Med Chem Lett; 2005 Oct; 15(19):4389-95. PubMed ID: 16098742
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor.
    Pontillo J; Tran JA; Fleck BA; Marinkovic D; Arellano M; Tucci FC; Lanier M; Nelson J; Parker J; Saunders J; Murphy B; Foster AC; Chen C
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5605-9. PubMed ID: 15482933
    [TBL] [Abstract][Full Text] [Related]  

  • 27. First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure.
    Leopoldo M; Lacivita E; Colabufo NA; Contino M; Berardi F; Perrone R
    J Med Chem; 2005 Dec; 48(25):7919-22. PubMed ID: 16335915
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.
    Tran JA; Jiang W; Tucci FC; Fleck BA; Wen J; Sai Y; Madan A; Chen TK; Markison S; Foster AC; Hoare SR; Marks D; Harman J; Chen CW; Arellano M; Marinkovic D; Bozigian H; Saunders J; Chen C
    J Med Chem; 2007 Dec; 50(25):6356-66. PubMed ID: 17994683
    [TBL] [Abstract][Full Text] [Related]  

  • 29. The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.
    Paluchowska MH; Bugno R; Duszyńska B; Tatarczyńska E; Nikiforuk A; Lenda T; Chojnacka-Wójcik E
    Bioorg Med Chem; 2007 Nov; 15(22):7116-25. PubMed ID: 17825569
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Substituted NDP-MSH peptides paired with mutant melanocortin-4 receptors demonstrate the role of transmembrane 6 in receptor activation.
    Fleck BA; Ling N; Chen C
    Biochemistry; 2007 Sep; 46(37):10473-83. PubMed ID: 17713970
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands.
    Song KS; Lee SH; Chun HJ; Kim JY; Jung ME; Ahn K; Kim SU; Kim J; Lee J
    Bioorg Med Chem; 2008 Apr; 16(7):4035-51. PubMed ID: 18243711
    [TBL] [Abstract][Full Text] [Related]  

  • 32. New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ".
    Mutulis F; Yahorava S; Mutule I; Yahorau A; Liepinsh E; Kopantshuk S; Veiksina S; Tars K; Belyakov S; Mishnev A; Rinken A; Wikberg JE
    J Med Chem; 2004 Aug; 47(18):4613-26. PubMed ID: 15317471
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Arylpiperazines with N-acylated amino acids as 5-HT1A receptor ligands.
    Zajdel P; Subra G; Bojarski AJ; Duszyńska B; Pawłowski M; Martinez J
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3406-10. PubMed ID: 16677812
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Preparation of piperazine derivatives as 5-HT7 receptor antagonists.
    Yoon J; Yoo EA; Kim JY; Pae AN; Rhim H; Park WK; Kong JY; Park Choo HY
    Bioorg Med Chem; 2008 May; 16(10):5405-12. PubMed ID: 18456500
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Synthesis and receptor binding studies of 3-substituted piperazine derivatives.
    Bedürftig S; Wünsch B
    Eur J Med Chem; 2006 Mar; 41(3):387-96. PubMed ID: 16446011
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
    Berardi F; Abate C; Ferorelli S; de Robertis AF; Leopoldo M; Colabufo NA; Niso M; Perrone R
    J Med Chem; 2008 Dec; 51(23):7523-31. PubMed ID: 19053780
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.
    Sebhat IK; Lai Y; Barakat K; Ye Z; Tang R; Kalyani RN; Vongs A; Macneil T; Weinberg DH; Cabello MA; Maroto M; Teran A; Fong TM; Van der Ploeg LH; Patchett AA; Nargund RP
    Bioorg Med Chem Lett; 2007 Oct; 17(20):5720-3. PubMed ID: 17768046
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors.
    Nahas RI; Lever JR; Lever SZ
    Bioorg Med Chem; 2008 Jan; 16(2):755-61. PubMed ID: 18029187
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists.
    Tian X; Chen X; Gan L; Hayes JC; Switzer AG; Solinsky MG; Ebetino FH; Wos JA; Pinney BB; Farmer JA; Crossdoersen D; Sheldon RJ
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1721-5. PubMed ID: 16376076
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor.
    Jiang W; Tucci FC; Tran JA; Fleck BA; Wen J; Markison S; Marinkovic D; Chen CW; Arellano M; Hoare SR; Johns M; Foster AC; Saunders J; Chen C
    Bioorg Med Chem Lett; 2007 Oct; 17(20):5610-3. PubMed ID: 17822895
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.