108 related articles for article (PubMed ID: 16686527)
1. Discovery and development of small-molecule chemokine coreceptor CCR5 antagonists.
Palani A; Tagat JR
J Med Chem; 2006 May; 49(10):2851-7. PubMed ID: 16686527
[No Abstract] [Full Text] [Related]
2. Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4.
Kazmierski WM; Kenakin TP; Gudmundsson KS
Chem Biol Drug Des; 2006 Jan; 67(1):13-26. PubMed ID: 16492145
[TBL] [Abstract][Full Text] [Related]
3. 4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents.
Duan M; Aquino C; Dorsey GF; Ferris R; Kazmierski WM
Bioorg Med Chem Lett; 2009 Sep; 19(17):4988-92. PubMed ID: 19664920
[TBL] [Abstract][Full Text] [Related]
4. Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety.
Seto M; Aikawa K; Miyamoto N; Aramaki Y; Kanzaki N; Takashima K; Kuze Y; Iizawa Y; Baba M; Shiraishi M
J Med Chem; 2006 Mar; 49(6):2037-48. PubMed ID: 16539392
[TBL] [Abstract][Full Text] [Related]
5. HIV coreceptor phenotyping in the clinical setting.
Low AJ; Swenson LC; Harrigan PR
AIDS Rev; 2008; 10(3):143-51. PubMed ID: 18820716
[TBL] [Abstract][Full Text] [Related]
6. The discovery of tropane-derived CCR5 receptor antagonists.
Armour DR; de Groot MJ; Price DA; Stammen BL; Wood A; Perros M; Burt C
Chem Biol Drug Des; 2006 Apr; 67(4):305-8. PubMed ID: 16629828
[TBL] [Abstract][Full Text] [Related]
7. Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity.
Imamura S; Ichikawa T; Nishikawa Y; Kanzaki N; Takashima K; Niwa S; Iizawa Y; Baba M; Sugihara Y
J Med Chem; 2006 May; 49(9):2784-93. PubMed ID: 16640339
[TBL] [Abstract][Full Text] [Related]
8. The discovery of CCR5 receptor antagonists for the treatment of HIV infection: hit-to-lead studies.
Armour D; de Groot MJ; Edwards M; Perros M; Price DA; Stammen BL; Wood A
ChemMedChem; 2006 Jul; 1(7):706-9. PubMed ID: 16902922
[No Abstract] [Full Text] [Related]
9. Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.
Wang T; Zhang Z; Wallace OB; Deshpande M; Fang H; Yang Z; Zadjura LM; Tweedie DL; Huang S; Zhao F; Ranadive S; Robinson BS; Gong YF; Ricarrdi K; Spicer TP; Deminie C; Rose R; Wang HG; Blair WS; Shi PY; Lin PF; Colonno RJ; Meanwell NA
J Med Chem; 2003 Sep; 46(20):4236-9. PubMed ID: 13678401
[TBL] [Abstract][Full Text] [Related]
10. Genotypic coreceptor analysis.
Sierra S; Kaiser R; Thielen A; Lengauer T
Eur J Med Res; 2007 Oct; 12(9):453-62. PubMed ID: 17933727
[TBL] [Abstract][Full Text] [Related]
11. Resistance profile of a neutralizing anti-HIV monoclonal antibody, KD-247, that shows favourable synergism with anti-CCR5 inhibitors.
Yoshimura K; Shibata J; Kimura T; Honda A; Maeda Y; Koito A; Murakami T; Mitsuya H; Matsushita S
AIDS; 2006 Oct; 20(16):2065-73. PubMed ID: 17053352
[TBL] [Abstract][Full Text] [Related]
12. Exploration of a new series of CCR5 antagonists: multi-dimensional optimization of a sub-series containing N-substituted pyrazoles.
Lemoine RC; Petersen AC; Setti L; Jekle A; Heilek G; deRosier A; Ji C; Berry P; Rotstein DM
Bioorg Med Chem Lett; 2010 Aug; 20(16):4753-6. PubMed ID: 20643548
[TBL] [Abstract][Full Text] [Related]
13. Discovery of N-benzyl-N'-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (II): modification of the acyl portion.
Duan M; Peckham J; Edelstein M; Ferris R; Kazmierski WM; Spaltenstein A; Wheelan P; Xiong Z
Bioorg Med Chem Lett; 2010 Dec; 20(24):7401-4. PubMed ID: 21055933
[TBL] [Abstract][Full Text] [Related]
14. CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives.
Imamura S; Nishikawa Y; Ichikawa T; Hattori T; Matsushita Y; Hashiguchi S; Kanzaki N; Iizawa Y; Baba M; Sugihara Y
Bioorg Med Chem; 2005 Jan; 13(2):397-416. PubMed ID: 15598561
[TBL] [Abstract][Full Text] [Related]
15. CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]-N,N'-diphenylureas.
Imamura S; Kurasawa O; Nara Y; Ichikawa T; Nishikawa Y; Iida T; Hashiguchi S; Kanzaki N; Iizawa Y; Baba M; Sugihara Y
Bioorg Med Chem; 2004 May; 12(9):2295-306. PubMed ID: 15080927
[TBL] [Abstract][Full Text] [Related]
16. Discovery of novel (S)-alpha-phenyl-gamma-amino butanamide containing CCR5 antagonists via functionality inversion approach.
Zhang HS; Feng DZ; Chen L; Long YQ
Bioorg Med Chem Lett; 2010 Apr; 20(7):2219-23. PubMed ID: 20207141
[TBL] [Abstract][Full Text] [Related]
17. What's in the works.
Horn T
Posit Living; 2001 Feb; 10(2):20-2. PubMed ID: 11548496
[No Abstract] [Full Text] [Related]
18. Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Kim D; Wang L; Hale JJ; Lynch CL; Budhu RJ; Maccoss M; Mills SG; Malkowitz L; Gould SL; DeMartino JA; Springer MS; Hazuda D; Miller M; Kessler J; Hrin RC; Carver G; Carella A; Henry K; Lineberger J; Schleif WA; Emini EA
Bioorg Med Chem Lett; 2005 Apr; 15(8):2129-34. PubMed ID: 15808483
[TBL] [Abstract][Full Text] [Related]
19. Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles.
Lemoine RC; Petersen AC; Setti L; Wanner J; Jekle A; Heilek G; deRosier A; Ji C; Berry P; Rotstein D
Bioorg Med Chem Lett; 2010 Jan; 20(2):704-8. PubMed ID: 20004099
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.
Habashita H; Kokubo M; Hamano S; Hamanaka N; Toda M; Shibayama S; Tada H; Sagawa K; Fukushima D; Maeda K; Mitsuya H
J Med Chem; 2006 Jul; 49(14):4140-52. PubMed ID: 16821774
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
