151 related articles for article (PubMed ID: 16698890)
1. In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay.
Lam JL; Okochi H; Huang Y; Benet LZ
Drug Metab Dispos; 2006 Aug; 34(8):1336-44. PubMed ID: 16698890
[TBL] [Abstract][Full Text] [Related]
2. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes.
Lam JL; Benet LZ
Drug Metab Dispos; 2004 Nov; 32(11):1311-6. PubMed ID: 15483198
[TBL] [Abstract][Full Text] [Related]
3. Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918.
Wu CY; Benet LZ
Drug Metab Dispos; 2003 Nov; 31(11):1292-5. PubMed ID: 14570757
[TBL] [Abstract][Full Text] [Related]
4. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.
Sun H; Huang Y; Frassetto L; Benet LZ
Drug Metab Dispos; 2004 Nov; 32(11):1239-46. PubMed ID: 15286055
[TBL] [Abstract][Full Text] [Related]
5. Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.
Lam JL; Shugarts SB; Okochi H; Benet LZ
J Pharmacol Exp Ther; 2006 Nov; 319(2):864-70. PubMed ID: 16905688
[TBL] [Abstract][Full Text] [Related]
6. Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the mouse, rat, dog, and monkey.
Ward KW; Azzarano LM
J Pharmacol Exp Ther; 2004 Aug; 310(2):703-9. PubMed ID: 15056727
[TBL] [Abstract][Full Text] [Related]
7. Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems.
Lau YY; Okochi H; Huang Y; Benet LZ
J Pharmacol Exp Ther; 2006 Feb; 316(2):762-71. PubMed ID: 16258024
[TBL] [Abstract][Full Text] [Related]
8. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.
Cummins CL; Salphati L; Reid MJ; Benet LZ
J Pharmacol Exp Ther; 2003 Apr; 305(1):306-14. PubMed ID: 12649383
[TBL] [Abstract][Full Text] [Related]
9. Role of P-glycoprotein in the hepatic metabolism of tacrolimus.
Jeong H; Chiou WL
Xenobiotica; 2006 Jan; 36(1):1-13. PubMed ID: 16507509
[TBL] [Abstract][Full Text] [Related]
10. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay.
Lau YY; Wu CY; Okochi H; Benet LZ
J Pharmacol Exp Ther; 2004 Mar; 308(3):1040-5. PubMed ID: 14634033
[TBL] [Abstract][Full Text] [Related]
11. Comparison of drug efflux transport kinetics in various blood-brain barrier models.
Bachmeier CJ; Trickler WJ; Miller DW
Drug Metab Dispos; 2006 Jun; 34(6):998-1003. PubMed ID: 16554372
[TBL] [Abstract][Full Text] [Related]
12. Metabolism and transporter-mediated drug-drug interactions of the endothelin-A receptor antagonist CI-1034.
Sahi J; Sinz MW; Campbell S; Mireles R; Zheng X; Rose KA; Raeissi S; Hashim MF; Ye Y; de Morais SM; Black C; Tugnait M; Keller LH
Chem Biol Interact; 2006 Feb; 159(2):156-68. PubMed ID: 16356485
[TBL] [Abstract][Full Text] [Related]
13. Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism.
Lau YY; Okochi H; Huang Y; Benet LZ
Drug Metab Dispos; 2006 Jul; 34(7):1175-81. PubMed ID: 16624870
[TBL] [Abstract][Full Text] [Related]
14. The complexity of intestinal absorption and exsorption of digoxin in rats.
Yao HM; Chiou WL
Int J Pharm; 2006 Sep; 322(1-2):79-86. PubMed ID: 16781832
[TBL] [Abstract][Full Text] [Related]
15. Rifampin induces the in vitro oxidative metabolism, but not the in vivo clearance of diclofenac in rhesus monkeys.
Prueksaritanont T; Li C; Tang C; Kuo Y; Strong-Basalyga K; Carr B
Drug Metab Dispos; 2006 Nov; 34(11):1806-10. PubMed ID: 16928785
[TBL] [Abstract][Full Text] [Related]
16. [Study on metabolism of tetramethylpyrazine in system of rat liver microsomes].
Kuang XD; Li XH; Xiong YQ
Zhongguo Zhong Yao Za Zhi; 2006 Dec; 31(23):1971-5. PubMed ID: 17348193
[TBL] [Abstract][Full Text] [Related]
17. Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: transporter-enzyme interplay.
Brown HS; Wilby AJ; Alder J; Houston JB
Drug Metab Dispos; 2010 Dec; 38(12):2139-46. PubMed ID: 20847136
[TBL] [Abstract][Full Text] [Related]
18. Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats.
Machavaram KK; Gundu J; Yamsani MR
Pharmazie; 2004 Dec; 59(12):957-60. PubMed ID: 15638086
[TBL] [Abstract][Full Text] [Related]
19. The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions.
Polli JW; Humphreys JE; Harmon KA; Castellino S; O'Mara MJ; Olson KL; John-Williams LS; Koch KM; Serabjit-Singh CJ
Drug Metab Dispos; 2008 Apr; 36(4):695-701. PubMed ID: 18216274
[TBL] [Abstract][Full Text] [Related]
20. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril.
Yuan H; Feng B; Yu Y; Chupka J; Zheng JY; Heath TG; Bond BR
J Pharmacol Exp Ther; 2009 Jul; 330(1):191-7. PubMed ID: 19349522
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
