These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

619 related articles for article (PubMed ID: 16710421)

  • 1. Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
    Wang J; Soisson SM; Young K; Shoop W; Kodali S; Galgoci A; Painter R; Parthasarathy G; Tang YS; Cummings R; Ha S; Dorso K; Motyl M; Jayasuriya H; Ondeyka J; Herath K; Zhang C; Hernandez L; Allocco J; Basilio A; Tormo JR; Genilloud O; Vicente F; Pelaez F; Colwell L; Lee SH; Michael B; Felcetto T; Gill C; Silver LL; Hermes JD; Bartizal K; Barrett J; Schmatz D; Becker JW; Cully D; Singh SB
    Nature; 2006 May; 441(7091):358-61. PubMed ID: 16710421
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological evaluation of platensimycin analogs.
    Shen HC; Ding FX; Singh SB; Parthasarathy G; Soisson SM; Ha SN; Chen X; Kodali S; Wang J; Dorso K; Tata JR; Hammond ML; Maccoss M; Colletti SL
    Bioorg Med Chem Lett; 2009 Mar; 19(6):1623-7. PubMed ID: 19233644
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.
    Singh SB; Jayasuriya H; Ondeyka JG; Herath KB; Zhang C; Zink DL; Tsou NN; Ball RG; Basilio A; Genilloud O; Diez MT; Vicente F; Pelaez F; Young K; Wang J
    J Am Chem Soc; 2006 Sep; 128(36):11916-20. PubMed ID: 16953632
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis.
    Zhang C; Ondeyka J; Zink DL; Burgess B; Wang J; Singh SB
    Chem Commun (Camb); 2008 Oct; (40):5034-6. PubMed ID: 18931777
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensis.
    Zhang C; Ondeyka J; Guan Z; Dietrich L; Burgess B; Wang J; Singh SB
    J Antibiot (Tokyo); 2009 Dec; 62(12):699-702. PubMed ID: 19911028
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents.
    Nie Z; Perretta C; Lu J; Su Y; Margosiak S; Gajiwala KS; Cortez J; Nikulin V; Yager KM; Appelt K; Chu S
    J Med Chem; 2005 Mar; 48(5):1596-609. PubMed ID: 15743201
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.
    Wang J; Kodali S; Lee SH; Galgoci A; Painter R; Dorso K; Racine F; Motyl M; Hernandez L; Tinney E; Colletti SL; Herath K; Cummings R; Salazar O; González I; Basilio A; Vicente F; Genilloud O; Pelaez F; Jayasuriya H; Young K; Cully DF; Singh SB
    Proc Natl Acad Sci U S A; 2007 May; 104(18):7612-6. PubMed ID: 17456595
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of platensimycin analogues and their antibiotic potency.
    Krauss J; Knorr V; Manhardt V; Scheffels S; Bracher F
    Arch Pharm (Weinheim); 2008 Jun; 341(6):386-92. PubMed ID: 18442030
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological evaluation of chromium bioorganometallics based on the antibiotic platensimycin lead structure.
    Patra M; Gasser G; Pinto A; Merz K; Ott I; Bandow JE; Metzler-Nolte N
    ChemMedChem; 2009 Nov; 4(11):1930-8. PubMed ID: 19784974
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of novel selective inhibitors of Staphylococcus aureus β-ketoacyl acyl carrier protein synthase III.
    Lee JY; Jeong KW; Shin S; Lee JU; Kim Y
    Eur J Med Chem; 2012 Jan; 47(1):261-9. PubMed ID: 22104972
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Recent advances on platensimycin: a potential antimicrobial agent.
    Lu X; You Q
    Curr Med Chem; 2010; 17(12):1139-55. PubMed ID: 20158476
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
    Jang KP; Kim CH; Na SW; Jang DS; Kim H; Kang H; Lee E
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2156-8. PubMed ID: 20207542
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.
    Gajiwala KS; Margosiak S; Lu J; Cortez J; Su Y; Nie Z; Appelt K
    FEBS Lett; 2009 Sep; 583(17):2939-46. PubMed ID: 19665020
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Platensimycin: a promising antimicrobial targeting fatty acid synthesis.
    Manallack DT; Crosby IT; Khakham Y; Capuano B
    Curr Med Chem; 2008; 15(7):705-10. PubMed ID: 18336284
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH).
    Shang R; Liang J; Yi Y; Liu Y; Wang J
    Molecules; 2015 Sep; 20(9):16127-41. PubMed ID: 26404223
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Isoplatensimycin: Synthesis and biological evaluation.
    Jang KP; Kim CH; Na SW; Kim H; Kang H; Lee E
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4601-2. PubMed ID: 19604693
    [TBL] [Abstract][Full Text] [Related]  

  • 17. An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.
    Haydon DJ; Stokes NR; Ure R; Galbraith G; Bennett JM; Brown DR; Baker PJ; Barynin VV; Rice DW; Sedelnikova SE; Heal JR; Sheridan JM; Aiwale ST; Chauhan PK; Srivastava A; Taneja A; Collins I; Errington J; Czaplewski LG
    Science; 2008 Sep; 321(5896):1673-5. PubMed ID: 18801997
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics.
    Lee JY; Jeong KW; Lee JU; Kang DI; Kim Y
    Bioorg Med Chem; 2009 Feb; 17(4):1506-13. PubMed ID: 19185501
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form.
    Baum B; Lecker LS; Zoltner M; Jaenicke E; Schnell R; Hunter WN; Brenk R
    Acta Crystallogr F Struct Biol Commun; 2015 Aug; 71(Pt 8):1020-6. PubMed ID: 26249693
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity.
    Oefner C; Bandera M; Haldimann A; Laue H; Schulz H; Mukhija S; Parisi S; Weiss L; Lociuro S; Dale GE
    J Antimicrob Chemother; 2009 Apr; 63(4):687-98. PubMed ID: 19211577
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 31.