218 related articles for article (PubMed ID: 16749864)
1. Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver.
Al-Dosari MS; Knapp JE; Liu D
Mol Pharm; 2006; 3(3):322-8. PubMed ID: 16749864
[TBL] [Abstract][Full Text] [Related]
2. Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors.
Falkner KC; Pinaire JA; Xiao GH; Geoghegan TE; Prough RA
Mol Pharmacol; 2001 Sep; 60(3):611-9. PubMed ID: 11502894
[TBL] [Abstract][Full Text] [Related]
3. Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.
Roth A; Looser R; Kaufmann M; Blättler SM; Rencurel F; Huang W; Moore DD; Meyer UA
Mol Pharmacol; 2008 Apr; 73(4):1282-9. PubMed ID: 18187584
[TBL] [Abstract][Full Text] [Related]
4. The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor.
Wyde ME; Bartolucci E; Ueda A; Zhang H; Yan B; Negishi M; You L
Mol Pharmacol; 2003 Aug; 64(2):474-81. PubMed ID: 12869653
[TBL] [Abstract][Full Text] [Related]
5. Gender dictates the nuclear receptor-mediated regulation of CYP3A44.
Anakk S; Huang W; Staudinger JL; Tan K; Cole TJ; Moore DD; Strobel HW
Drug Metab Dispos; 2007 Jan; 35(1):36-42. PubMed ID: 17020958
[TBL] [Abstract][Full Text] [Related]
6. Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.
Cheng X; Maher J; Dieter MZ; Klaassen CD
Drug Metab Dispos; 2005 Sep; 33(9):1276-82. PubMed ID: 15919853
[TBL] [Abstract][Full Text] [Related]
7. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
Kast HR; Goodwin B; Tarr PT; Jones SA; Anisfeld AM; Stoltz CM; Tontonoz P; Kliewer S; Willson TM; Edwards PA
J Biol Chem; 2002 Jan; 277(4):2908-15. PubMed ID: 11706036
[TBL] [Abstract][Full Text] [Related]
8. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.
Wang H; Faucette S; Sueyoshi T; Moore R; Ferguson S; Negishi M; LeCluyse EL
J Biol Chem; 2003 Apr; 278(16):14146-52. PubMed ID: 12571232
[TBL] [Abstract][Full Text] [Related]
9. Rabbit pregnane X receptor is activated by rifampicin.
Savas U; Wester MR; Griffin KJ; Johnson EF
Drug Metab Dispos; 2000 May; 28(5):529-37. PubMed ID: 10772631
[TBL] [Abstract][Full Text] [Related]
10. Kupffer cells and reactive oxygen species partially mediate lipopolysaccharide-induced downregulation of nuclear receptor pregnane x receptor and its target gene CYP3a in mouse liver.
Xu DX; Wei W; Sun MF; Wu CY; Wang JP; Wei LZ; Zhou CF
Free Radic Biol Med; 2004 Jul; 37(1):10-22. PubMed ID: 15183191
[TBL] [Abstract][Full Text] [Related]
11. o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver.
Kiyosawa N; Kwekel JC; Burgoon LD; Williams KJ; Tashiro C; Chittim B; Zacharewski TR
Toxicol Sci; 2008 Feb; 101(2):350-63. PubMed ID: 17984292
[TBL] [Abstract][Full Text] [Related]
12. Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes.
Dvorák Z; Maurel P; Vilarem MJ; Ulrichová J; Modrianský M
Cell Biol Toxicol; 2007 Mar; 23(2):63-73. PubMed ID: 16964586
[TBL] [Abstract][Full Text] [Related]
13. Constitutive androstane receptor (CAR) as a potential sensing biomarker of persistent organic pollutants (POPs) in aquatic mammal: molecular characterization, expression level, and ligand profiling in Baikal seal (Pusa sibirica).
Sakai H; Iwata H; Kim EY; Tsydenova O; Miyazaki N; Petrov EA; Batoev VB; Tanabe S
Toxicol Sci; 2006 Nov; 94(1):57-70. PubMed ID: 16929008
[TBL] [Abstract][Full Text] [Related]
14. Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.
Ferguson SS; LeCluyse EL; Negishi M; Goldstein JA
Mol Pharmacol; 2002 Sep; 62(3):737-46. PubMed ID: 12181452
[TBL] [Abstract][Full Text] [Related]
15. Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.
Aouabdi S; Gibson G; Plant N
Drug Metab Dispos; 2006 Jan; 34(1):138-44. PubMed ID: 16243957
[TBL] [Abstract][Full Text] [Related]
16. The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.
Chen Y; Kissling G; Negishi M; Goldstein JA
J Pharmacol Exp Ther; 2005 Sep; 314(3):1125-33. PubMed ID: 15919766
[TBL] [Abstract][Full Text] [Related]
17. Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha.
Itoh M; Nakajima M; Higashi E; Yoshida R; Nagata K; Yamazoe Y; Yokoi T
J Pharmacol Exp Ther; 2006 Nov; 319(2):693-702. PubMed ID: 16857725
[TBL] [Abstract][Full Text] [Related]
18. Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.
Pascussi JM; Gerbal-Chaloin S; Pichard-Garcia L; Daujat M; Fabre JM; Maurel P; Vilarem MJ
Biochem Biophys Res Commun; 2000 Aug; 274(3):707-13. PubMed ID: 10924340
[TBL] [Abstract][Full Text] [Related]
19. Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.
Chen Y; Ferguson SS; Negishi M; Goldstein JA
J Pharmacol Exp Ther; 2004 Feb; 308(2):495-501. PubMed ID: 14600250
[TBL] [Abstract][Full Text] [Related]
20. Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice in vivo.
Slatter JG; Cheng O; Cornwell PD; de Souza A; Rockett J; Rushmore T; Hartley D; Evers R; He Y; Dai X; Hu R; Caguyong M; Roberts CJ; Castle J; Ulrich RG
Xenobiotica; 2006; 36(10-11):902-37. PubMed ID: 17118914
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]