208 related articles for article (PubMed ID: 16754663)
1. Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.
Ang HC; Joerger AC; Mayer S; Fersht AR
J Biol Chem; 2006 Aug; 281(31):21934-21941. PubMed ID: 16754663
[TBL] [Abstract][Full Text] [Related]
2. Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study.
Kamaraj B; Bogaerts A
PLoS One; 2015; 10(8):e0134638. PubMed ID: 26244575
[TBL] [Abstract][Full Text] [Related]
3. Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue.
Wallentine BD; Wang Y; Tretyachenko-Ladokhina V; Tan M; Senear DF; Luecke H
Acta Crystallogr D Biol Crystallogr; 2013 Oct; 69(Pt 10):2146-56. PubMed ID: 24100332
[TBL] [Abstract][Full Text] [Related]
4. Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function.
Lubin DJ; Butler JS; Loh SN
J Mol Biol; 2010 Jan; 395(4):705-16. PubMed ID: 19913028
[TBL] [Abstract][Full Text] [Related]
5. Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insights.
Merabet A; Houlleberghs H; Maclagan K; Akanho E; Bui TT; Pagano B; Drake AF; Fraternali F; Nikolova PV
Biochem J; 2010 Mar; 427(2):225-36. PubMed ID: 20113312
[TBL] [Abstract][Full Text] [Related]
6. A common gain of function of p53 cancer mutants in inducing genetic instability.
Liu DP; Song H; Xu Y
Oncogene; 2010 Feb; 29(7):949-56. PubMed ID: 19881536
[TBL] [Abstract][Full Text] [Related]
7. Kinetic instability of p53 core domain mutants: implications for rescue by small molecules.
Friedler A; Veprintsev DB; Hansson LO; Fersht AR
J Biol Chem; 2003 Jun; 278(26):24108-12. PubMed ID: 12700230
[TBL] [Abstract][Full Text] [Related]
8. Factors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain.
Wright JD; Noskov SY; Lim C
Nucleic Acids Res; 2002 Apr; 30(7):1563-74. PubMed ID: 11917017
[TBL] [Abstract][Full Text] [Related]
9. CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73.
Demma MJ; Wong S; Maxwell E; Dasmahapatra B
J Biol Chem; 2004 Oct; 279(44):45887-96. PubMed ID: 15308639
[TBL] [Abstract][Full Text] [Related]
10. Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain.
Calhoun S; Daggett V
Biochemistry; 2011 Jun; 50(23):5345-53. PubMed ID: 21561095
[TBL] [Abstract][Full Text] [Related]
11. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations.
Joerger AC; Allen MD; Fersht AR
J Biol Chem; 2004 Jan; 279(2):1291-6. PubMed ID: 14534297
[TBL] [Abstract][Full Text] [Related]
12. A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants.
Friedler A; Hansson LO; Veprintsev DB; Freund SM; Rippin TM; Nikolova PV; Proctor MR; Rüdiger S; Fersht AR
Proc Natl Acad Sci U S A; 2002 Jan; 99(2):937-42. PubMed ID: 11782540
[TBL] [Abstract][Full Text] [Related]
13. Thermodynamic stability of wild-type and mutant p53 core domain.
Bullock AN; Henckel J; DeDecker BS; Johnson CM; Nikolova PV; Proctor MR; Lane DP; Fersht AR
Proc Natl Acad Sci U S A; 1997 Dec; 94(26):14338-42. PubMed ID: 9405613
[TBL] [Abstract][Full Text] [Related]
14. Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.
Rippin TM; Bykov VJ; Freund SM; Selivanova G; Wiman KG; Fersht AR
Oncogene; 2002 Mar; 21(14):2119-29. PubMed ID: 11948395
[TBL] [Abstract][Full Text] [Related]
15. p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.
Song H; Hollstein M; Xu Y
Nat Cell Biol; 2007 May; 9(5):573-80. PubMed ID: 17417627
[TBL] [Abstract][Full Text] [Related]
16. Hot-spot mutants of p53 core domain evince characteristic local structural changes.
Wong KB; DeDecker BS; Freund SM; Proctor MR; Bycroft M; Fersht AR
Proc Natl Acad Sci U S A; 1999 Jul; 96(15):8438-42. PubMed ID: 10411893
[TBL] [Abstract][Full Text] [Related]
17. The p73 DNA binding domain displays enhanced stability relative to its homologue, the tumor suppressor p53, and exhibits cooperative DNA binding.
Patel S; Bui TT; Drake AF; Fraternali F; Nikolova PV
Biochemistry; 2008 Mar; 47(10):3235-44. PubMed ID: 18260640
[TBL] [Abstract][Full Text] [Related]
18. Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.
Khoo KH; Joerger AC; Freund SM; Fersht AR
Protein Eng Des Sel; 2009 Jul; 22(7):421-30. PubMed ID: 19515728
[TBL] [Abstract][Full Text] [Related]
19. Effects of temperature on the p53-DNA binding interactions and their dynamical behavior: comparing the wild type to the R248Q mutant.
Barakat K; Issack BB; Stepanova M; Tuszynski J
PLoS One; 2011; 6(11):e27651. PubMed ID: 22110706
[TBL] [Abstract][Full Text] [Related]
20. Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.
Puca R; Nardinocchi L; Porru M; Simon AJ; Rechavi G; Leonetti C; Givol D; D'Orazi G
Cell Cycle; 2011 May; 10(10):1679-89. PubMed ID: 21508668
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]