228 related articles for article (PubMed ID: 16756946)
1. Protease digestion indicates that endogenous presenilin 1 is present in at least two physical forms.
Oh YS; Turner RJ
Biochem Biophys Res Commun; 2006 Jul; 346(1):330-4. PubMed ID: 16756946
[TBL] [Abstract][Full Text] [Related]
2. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
3. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
4. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
[TBL] [Abstract][Full Text] [Related]
5. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.
Brunkan AL; Martinez M; Wang J; Walker ES; Beher D; Shearman MS; Goate AM
J Neurochem; 2005 Sep; 94(5):1315-28. PubMed ID: 16001967
[TBL] [Abstract][Full Text] [Related]
6. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
[TBL] [Abstract][Full Text] [Related]
7. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
Neurobiol Dis; 2004 Apr; 15(3):654-66. PubMed ID: 15056474
[TBL] [Abstract][Full Text] [Related]
8. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
Lai MT; Crouthamel MC; DiMuzio J; Pietrak BL; Donoviel DB; Bernstein A; Gardell SJ; Li YM; Hazuda D
J Neurochem; 2006 Jan; 96(1):118-25. PubMed ID: 16300640
[TBL] [Abstract][Full Text] [Related]
9. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
10. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; Wilson CA; Lee VM; Doms RW
Biochemistry; 2004 Mar; 43(12):3555-63. PubMed ID: 15035625
[TBL] [Abstract][Full Text] [Related]
11. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
Siman R; Salidas S
Neuroscience; 2004; 129(3):615-28. PubMed ID: 15541883
[TBL] [Abstract][Full Text] [Related]
12. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
Kaether C; Capell A; Edbauer D; Winkler E; Novak B; Steiner H; Haass C
EMBO J; 2004 Dec; 23(24):4738-48. PubMed ID: 15549135
[TBL] [Abstract][Full Text] [Related]
13. In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.
Beher D; Fricker M; Nadin A; Clarke EE; Wrigley JD; Li YM; Culvenor JG; Masters CL; Harrison T; Shearman MS
Biochemistry; 2003 Jul; 42(27):8133-42. PubMed ID: 12846562
[TBL] [Abstract][Full Text] [Related]
14. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
Knappenberger KS; Tian G; Ye X; Sobotka-Briner C; Ghanekar SV; Greenberg BD; Scott CW
Biochemistry; 2004 May; 43(20):6208-18. PubMed ID: 15147205
[TBL] [Abstract][Full Text] [Related]
15. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
J Neurochem; 2004 Apr; 89(1):44-53. PubMed ID: 15030388
[TBL] [Abstract][Full Text] [Related]
16. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; Serneels L; Saftig P; Craessaerts K; De Strooper B; Hartmann D
Hum Mol Genet; 2004 Jul; 13(13):1321-31. PubMed ID: 15128703
[TBL] [Abstract][Full Text] [Related]
17. Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
Selkoe DJ
Proc Natl Acad Sci U S A; 2001 Sep; 98(20):11039-41. PubMed ID: 11572965
[TBL] [Abstract][Full Text] [Related]
18. Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage.
Qyang Y; Chambers SM; Wang P; Xia X; Chen X; Goodell MA; Zheng H
Biochemistry; 2004 May; 43(18):5352-9. PubMed ID: 15122901
[TBL] [Abstract][Full Text] [Related]
19. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
[TBL] [Abstract][Full Text] [Related]
20. Presenilin function and gamma-secretase activity.
Brunkan AL; Goate AM
J Neurochem; 2005 May; 93(4):769-92. PubMed ID: 15857382
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]