These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

161 related articles for article (PubMed ID: 16768448)

  • 1. Electronic and nuclear magnetic resonance spectroscopic features of the 1',4'-iminopyrimidine tautomeric form of thiamin diphosphate, a novel intermediate on enzymes requiring this coenzyme.
    Baykal AT; Kakalis L; Jordan F
    Biochemistry; 2006 Jun; 45(24):7522-8. PubMed ID: 16768448
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dual catalytic apparatus of the thiamin diphosphate coenzyme: acid-base via the 1',4'-iminopyrimidine tautomer along with its electrophilic role.
    Jordan F; Nemeria NS; Zhang S; Yan Y; Arjunan P; Furey W
    J Am Chem Soc; 2003 Oct; 125(42):12732-8. PubMed ID: 14558820
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Spectroscopic evidence for participation of the 1',4'-imino tautomer of thiamin diphosphate in catalysis by yeast pyruvate decarboxylase.
    Jordan F; Zhang Z; Sergienko E
    Bioorg Chem; 2002 Jun; 30(3):188-98. PubMed ID: 12406703
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tetrahedral intermediates in thiamin diphosphate-dependent decarboxylations exist as a 1',4'-imino tautomeric form of the coenzyme, unlike the michaelis complex or the free coenzyme.
    Nemeria N; Baykal A; Joseph E; Zhang S; Yan Y; Furey W; Jordan F
    Biochemistry; 2004 Jun; 43(21):6565-75. PubMed ID: 15157089
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states.
    Nemeria N; Korotchkina L; McLeish MJ; Kenyon GL; Patel MS; Jordan F
    Biochemistry; 2007 Sep; 46(37):10739-44. PubMed ID: 17715948
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes.
    Nemeria N; Chakraborty S; Baykal A; Korotchkina LG; Patel MS; Jordan F
    Proc Natl Acad Sci U S A; 2007 Jan; 104(1):78-82. PubMed ID: 17182735
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Glyoxylate carboligase: a unique thiamin diphosphate-dependent enzyme that can cycle between the 4'-aminopyrimidinium and 1',4'-iminopyrimidine tautomeric forms in the absence of the conserved glutamate.
    Nemeria N; Binshtein E; Patel H; Balakrishnan A; Vered I; Shaanan B; Barak Z; Chipman D; Jordan F
    Biochemistry; 2012 Oct; 51(40):7940-52. PubMed ID: 22970650
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Bifunctionality of the thiamin diphosphate cofactor: assignment of tautomeric/ionization states of the 4'-aminopyrimidine ring when various intermediates occupy the active sites during the catalysis of yeast pyruvate decarboxylase.
    Balakrishnan A; Gao Y; Moorjani P; Nemeria NS; Tittmann K; Jordan F
    J Am Chem Soc; 2012 Feb; 134(8):3873-85. PubMed ID: 22300533
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A DFT study of solvation effects on the tautomeric equilibrium and catalytic ylide generation of thiamin models.
    Alstrup Lie M; Schiøtt B
    J Comput Chem; 2008 May; 29(7):1037-47. PubMed ID: 18058864
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The molecular origin of the thiamine diphosphate-induced spectral bands of ThDP-dependent enzymes.
    Kovina MV; De Kok A; Sevostyanova IA; Khailova LS; Belkina NV; Kochetov GA
    Proteins; 2004 Aug; 56(2):338-45. PubMed ID: 15211516
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Theoretical studies on the electronic and energetic properties of the aminopyrimidine part of thiamin diphosphate.
    Friedemann R; Neef H
    Biochim Biophys Acta; 1998 Jun; 1385(2):245-50. PubMed ID: 9655914
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Solid-state nuclear magnetic resonance studies delineate the role of the protein in activation of both aromatic rings of thiamin.
    Balakrishnan A; Paramasivam S; Chakraborty S; Polenova T; Jordan F
    J Am Chem Soc; 2012 Jan; 134(1):665-72. PubMed ID: 22092024
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Induced absorption band of holotransketolase and its interpretation.
    Kovina MV; Bykova IA; Meshalkina LE; Kochetov GA
    Biochemistry (Mosc); 2003 Feb; 68(2):247-51. PubMed ID: 12693972
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Solid-state NMR and density functional theory studies of ionization states of thiamin.
    Paramasivam S; Balakrishnan A; Dmitrenko O; Godert A; Begley TP; Jordan F; Polenova T
    J Phys Chem B; 2011 Feb; 115(4):730-6. PubMed ID: 21175136
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The origin of the absorption band induced through the interaction between apotransketolase and thiamin diphosphate.
    Kovina MV; Bykova IA; Solovjeva ON; Meshalkina LE; Kochetov GA
    Biochem Biophys Res Commun; 2002 May; 294(1):155-60. PubMed ID: 12054756
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Kinetic control of thiamin diphosphate activation in enzymes studied by proton-nitrogen correlated NMR spectroscopy.
    Tittmann K; Neef H; Golbik R; Hübner G; Kern D
    Biochemistry; 2005 Jun; 44(24):8697-700. PubMed ID: 15952776
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cofactor activation and substrate binding in pyruvate decarboxylase. Insights into the reaction mechanism from molecular dynamics simulations.
    Lie MA; Celik L; Jørgensen KA; Schiøtt B
    Biochemistry; 2005 Nov; 44(45):14792-806. PubMed ID: 16274227
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Theoretical Studies of the Electronic Absorption Spectra of Thiamin Diphosphate in Pyruvate Decarboxylase.
    Paulikat M; Wechsler C; Tittmann K; Mata RA
    Biochemistry; 2017 Apr; 56(13):1854-1864. PubMed ID: 28296385
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Reaction mechanisms of thiamin diphosphate enzymes: new insights into the role of a conserved glutamate residue.
    Shaanan B; Chipman DM
    FEBS J; 2009 May; 276(9):2447-53. PubMed ID: 19476486
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps.
    Nemeria NS; Chakraborty S; Balakrishnan A; Jordan F
    FEBS J; 2009 May; 276(9):2432-46. PubMed ID: 19476485
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.