184 related articles for article (PubMed ID: 16776571)
1. Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
Lu Y; Tang M; Wasserfall C; Kou Z; Campbell-Thompson M; Gardemann T; Crawford J; Atkinson M; Song S
Hum Gene Ther; 2006 Jun; 17(6):625-34. PubMed ID: 16776571
[TBL] [Abstract][Full Text] [Related]
2. Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice.
Song S; Goudy K; Campbell-Thompson M; Wasserfall C; Scott-Jorgensen M; Wang J; Tang Q; Crawford JM; Ellis TM; Atkinson MA; Flotte TR
Gene Ther; 2004 Jan; 11(2):181-6. PubMed ID: 14712302
[TBL] [Abstract][Full Text] [Related]
3. Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors.
Lu Y; Song S
Proc Natl Acad Sci U S A; 2009 Oct; 106(40):17158-62. PubMed ID: 19805176
[TBL] [Abstract][Full Text] [Related]
4. Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Goudy KS; Burkhardt BR; Wasserfall C; Song S; Campbell-Thompson ML; Brusko T; Powers MA; Clare-Salzler MJ; Sobel ES; Ellis TM; Flotte TR; Atkinson MA
J Immunol; 2003 Sep; 171(5):2270-8. PubMed ID: 12928371
[TBL] [Abstract][Full Text] [Related]
5. Suppression of autoimmune diabetes by viral IL-10 gene transfer.
Yang Z; Chen M; Wu R; Fialkow LB; Bromberg JS; McDuffie M; Naji A; Nadler JL
J Immunol; 2002 Jun; 168(12):6479-85. PubMed ID: 12055268
[TBL] [Abstract][Full Text] [Related]
6. Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults.
Flotte TR; Brantly ML; Spencer LT; Byrne BJ; Spencer CT; Baker DJ; Humphries M
Hum Gene Ther; 2004 Jan; 15(1):93-128. PubMed ID: 14965381
[TBL] [Abstract][Full Text] [Related]
7. In Vivo Analysis of Alpha-1-Antitrypsin Functions in Autoimmune Disease Models.
Song S; Lu Y; Elshikha AS
Methods Mol Biol; 2018; 1826():143-155. PubMed ID: 30194599
[TBL] [Abstract][Full Text] [Related]
8. Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector.
Lu Y; Choi YK; Campbell-Thompson M; Li C; Tang Q; Crawford JM; Flotte TR; Song S
J Gene Med; 2006 Jun; 8(6):730-5. PubMed ID: 16518879
[TBL] [Abstract][Full Text] [Related]
9. Gene delivery GAD 500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: transduction efficiency do not play important roles.
Han G; Wang R; Chen G; Wang J; Xu R; Feng J; Yu M; Wu X; Qian J; Shen B; Li Y
Immunol Lett; 2008 Jan; 115(2):110-6. PubMed ID: 18045698
[TBL] [Abstract][Full Text] [Related]
10. Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
Goudy K; Song S; Wasserfall C; Zhang YC; Kapturczak M; Muir A; Powers M; Scott-Jorgensen M; Campbell-Thompson M; Crawford JM; Ellis TM; Flotte TR; Atkinson MA
Proc Natl Acad Sci U S A; 2001 Nov; 98(24):13913-8. PubMed ID: 11717448
[TBL] [Abstract][Full Text] [Related]
11. Alpha-1-antitrypsin for the improvement of autoimmunity and allograft rejection in beta cell transplantation.
Ye J; Liao YT; Jian YQ; Zhang XD; Wei P; Qi H; Deng CY; Li FR
Immunol Lett; 2013 Feb; 150(1-2):61-8. PubMed ID: 23333354
[TBL] [Abstract][Full Text] [Related]
12. Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector.
Conlon TJ; Cossette T; Erger K; Choi YK; Clarke T; Scott-Jorgensen M; Song S; Campbell-Thompson M; Crawford J; Flotte TR
Mol Ther; 2005 Nov; 12(5):867-75. PubMed ID: 16085464
[TBL] [Abstract][Full Text] [Related]
13. Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease.
Ma H; Lu Y; Li H; Campbell-Thompson M; Parker M; Wasserfall C; Haller M; Brantly M; Schatz D; Atkinson M; Song S
Diabetologia; 2010 Oct; 53(10):2198-204. PubMed ID: 20593162
[TBL] [Abstract][Full Text] [Related]
14. Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.
Brantly ML; Chulay JD; Wang L; Mueller C; Humphries M; Spencer LT; Rouhani F; Conlon TJ; Calcedo R; Betts MR; Spencer C; Byrne BJ; Wilson JM; Flotte TR
Proc Natl Acad Sci U S A; 2009 Sep; 106(38):16363-8. PubMed ID: 19706466
[TBL] [Abstract][Full Text] [Related]
15. Expression of IL-2 in β cells by AAV8 gene transfer in pre-diabetic NOD mice prevents diabetes through activation of FoxP3-positive regulatory T cells.
Flores RR; Zhou L; Robbins PD
Gene Ther; 2014 Aug; 21(8):715-22. PubMed ID: 24849041
[TBL] [Abstract][Full Text] [Related]
16. Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results.
Flotte TR; Trapnell BC; Humphries M; Carey B; Calcedo R; Rouhani F; Campbell-Thompson M; Yachnis AT; Sandhaus RA; McElvaney NG; Mueller C; Messina LM; Wilson JM; Brantly M; Knop DR; Ye GJ; Chulay JD
Hum Gene Ther; 2011 Oct; 22(10):1239-47. PubMed ID: 21609134
[TBL] [Abstract][Full Text] [Related]
17. Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes.
Goudy KS; Johnson MC; Garland A; Li C; Samulski RJ; Wang B; Tisch R
J Immunol; 2011 Mar; 186(6):3779-86. PubMed ID: 21317396
[TBL] [Abstract][Full Text] [Related]
18. Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-beta?
Song L; Wang J; Wang R; Yu M; Sun Y; Han G; Li Y; Qian J; Scott DW; Kang Y; Soukhareva N; Shen B
Gene Ther; 2004 Oct; 11(20):1487-96. PubMed ID: 15343360
[TBL] [Abstract][Full Text] [Related]
19. Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors.
Song S; Embury J; Laipis PJ; Berns KI; Crawford JM; Flotte TR
Gene Ther; 2001 Sep; 8(17):1299-306. PubMed ID: 11571566
[TBL] [Abstract][Full Text] [Related]
20. Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and dissemination of vector genomes to distant sites.
Flotte TR; Conlon TJ; Poirier A; Campbell-Thompson M; Byrne BJ
Hum Gene Ther; 2007 Mar; 18(3):245-56. PubMed ID: 17376008
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]