184 related articles for article (PubMed ID: 16780356)
1. Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator.
Liu H; Bolton JL; Thatcher GR
Chem Res Toxicol; 2006 Jun; 19(6):779-87. PubMed ID: 16780356
[TBL] [Abstract][Full Text] [Related]
2. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.
Liu H; Liu J; van Breemen RB; Thatcher GR; Bolton JL
Chem Res Toxicol; 2005 Feb; 18(2):162-73. PubMed ID: 15720120
[TBL] [Abstract][Full Text] [Related]
3. Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene.
Liu H; Qin Z; Thatcher GR; Bolton JL
Chem Res Toxicol; 2007 Nov; 20(11):1676-84. PubMed ID: 17630709
[TBL] [Abstract][Full Text] [Related]
4. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators.
Qin Z; Kastrati I; Ashgodom RT; Lantvit DD; Overk CR; Choi Y; van Breemen RB; Bolton JL; Thatcher GR
Drug Metab Dispos; 2009 Jan; 37(1):161-9. PubMed ID: 18936111
[TBL] [Abstract][Full Text] [Related]
5. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.
Yu B; Dietz BM; Dunlap T; Kastrati I; Lantvit DD; Overk CR; Yao P; Qin Z; Bolton JL; Thatcher GR
Mol Cancer Ther; 2007 Sep; 6(9):2418-28. PubMed ID: 17876041
[TBL] [Abstract][Full Text] [Related]
6. Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells.
Kastrati I; Edirisinghe PD; Hemachandra LP; Chandrasena ER; Choi J; Wang YT; Bolton JL; Thatcher GR
PLoS One; 2011; 6(11):e27876. PubMed ID: 22140478
[TBL] [Abstract][Full Text] [Related]
7. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene.
Overk CR; Peng KW; Asghodom RT; Kastrati I; Lantvit DD; Qin Z; Frasor J; Bolton JL; Thatcher GR
ChemMedChem; 2007 Oct; 2(10):1520-6. PubMed ID: 17654759
[TBL] [Abstract][Full Text] [Related]
8. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity.
Qin Z; Kastrati I; Chandrasena RE; Liu H; Yao P; Petukhov PA; Bolton JL; Thatcher GR
J Med Chem; 2007 May; 50(11):2682-92. PubMed ID: 17489582
[TBL] [Abstract][Full Text] [Related]
9. Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells.
Peng KW; Wang H; Qin Z; Wijewickrama GT; Lu M; Wang Z; Bolton JL; Thatcher GR
ACS Chem Biol; 2009 Dec; 4(12):1039-49. PubMed ID: 19839584
[TBL] [Abstract][Full Text] [Related]
10. Metabolism studies of 4'Cl-CUMYL-PINACA, 4'F-CUMYL-5F-PINACA and 4'F-CUMYL-5F-PICA using human hepatocytes and LC-QTOF-MS analysis.
Stalberga D; Ingvarsson S; Bessa G; Maas L; Vikingsson S; Persson M; Norman C; Gréen H
Basic Clin Pharmacol Toxicol; 2023 Mar; 132(3):263-280. PubMed ID: 36544361
[TBL] [Abstract][Full Text] [Related]
11. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.
Gherezghiher TB; Michalsen B; Chandrasena RE; Qin Z; Sohn J; Thatcher GR; Bolton JL
Chem Biol Interact; 2012 Mar; 196(1-2):1-10. PubMed ID: 22290292
[TBL] [Abstract][Full Text] [Related]
12. SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites.
Hemachandra LP; Patel H; Chandrasena RE; Choi J; Piyankarage SC; Wang S; Wang Y; Thayer EN; Scism RA; Michalsen BT; Xiong R; Siklos MI; Bolton JL; Thatcher GR
Cancer Prev Res (Phila); 2014 May; 7(5):505-15. PubMed ID: 24598415
[TBL] [Abstract][Full Text] [Related]
13. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
Liu J; Liu H; van Breemen RB; Thatcher GR; Bolton JL
Chem Res Toxicol; 2005 Feb; 18(2):174-82. PubMed ID: 15720121
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons.
Zhao L; Jin C; Mao Z; Gopinathan MB; Rehder K; Brinton RD
J Med Chem; 2007 Sep; 50(18):4471-81. PubMed ID: 17696335
[TBL] [Abstract][Full Text] [Related]
15. Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators.
Lloyd DG; Smith HM; O'Sullivan T; Zisterer DM; Meegan MJ
Med Chem; 2005 Jul; 1(4):335-53. PubMed ID: 16789891
[TBL] [Abstract][Full Text] [Related]
16. Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.
Yu B; Qin Z; Wijewickrama GT; Edirisinghe P; Bolton JL; Thatcher GR
Bioconjug Chem; 2009 Apr; 20(4):728-41. PubMed ID: 19301905
[TBL] [Abstract][Full Text] [Related]
17. The effect of the new SERM arzoxifene on growth and gene expression in MCF-7 breast cancer cells.
Freddie CT; Larsen SS; Bartholomaeussen M; Lykkesfeldt AE
Mol Cell Endocrinol; 2004 Apr; 219(1-2):27-36. PubMed ID: 15149724
[TBL] [Abstract][Full Text] [Related]
18. Symmetric 4,4'-(piperidin-4-ylidenemethylene)bisphenol derivatives as novel tunable estrogen receptor (ER) modulators.
Sato M; Ohta K; Kaise A; Aoto S; Endo Y
Bioorg Med Chem; 2016 Mar; 24(5):1089-94. PubMed ID: 26822566
[TBL] [Abstract][Full Text] [Related]
19. TAS-108, a novel oral steroidal antiestrogenic agent, is a pure antagonist on estrogen receptor alpha and a partial agonist on estrogen receptor beta with low uterotrophic effect.
Yamamoto Y; Shibata J; Yonekura K; Sato K; Hashimoto A; Aoyagi Y; Wierzba K; Yano S; Asao T; Buzdar AU; Terada T
Clin Cancer Res; 2005 Jan; 11(1):315-22. PubMed ID: 15671561
[TBL] [Abstract][Full Text] [Related]
20. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.
Bianco NR; Perry G; Smith MA; Templeton DJ; Montano MM
Mol Endocrinol; 2003 Jul; 17(7):1344-55. PubMed ID: 12714703
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
