173 related articles for article (PubMed ID: 16782806)
1. Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine.
Liang K; Lu Y; Li X; Zeng X; Glazer RI; Mills GB; Fan Z
Mol Pharmacol; 2006 Sep; 70(3):1045-52. PubMed ID: 16782806
[TBL] [Abstract][Full Text] [Related]
2. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
Ding Z; Liang J; Li J; Lu Y; Ariyaratna V; Lu Z; Davies MA; Westwick JK; Mills GB
PLoS One; 2010 Mar; 5(3):e9910. PubMed ID: 20361045
[TBL] [Abstract][Full Text] [Related]
3. 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.
Gagliardi PA; di Blasio L; Orso F; Seano G; Sessa R; Taverna D; Bussolino F; Primo L
Neoplasia; 2012 Aug; 14(8):719-31. PubMed ID: 22952425
[TBL] [Abstract][Full Text] [Related]
4. Modulation in activation and expression of phosphatase and tensin homolog on chromosome ten, Akt1, and 3-phosphoinositide-dependent kinase 1: further evidence demonstrating altered phosphoinositide 3-kinase signaling in postmortem brain of suicide subjects.
Dwivedi Y; Rizavi HS; Zhang H; Roberts RC; Conley RR; Pandey GN
Biol Psychiatry; 2010 Jun; 67(11):1017-25. PubMed ID: 20163786
[TBL] [Abstract][Full Text] [Related]
5. PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.
Tsuchiya A; Kanno T; Nishizaki T
J Endocrinol; 2014 Jan; 220(1):49-59. PubMed ID: 24169049
[TBL] [Abstract][Full Text] [Related]
6. Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha.
Zeng X; Xu H; Glazer RI
Cancer Res; 2002 Jun; 62(12):3538-43. PubMed ID: 12068001
[TBL] [Abstract][Full Text] [Related]
7. HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.
Knuefermann C; Lu Y; Liu B; Jin W; Liang K; Wu L; Schmidt M; Mills GB; Mendelsohn J; Fan Z
Oncogene; 2003 May; 22(21):3205-12. PubMed ID: 12761490
[TBL] [Abstract][Full Text] [Related]
8. Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation.
Miralem T; Lerner-Marmarosh N; Gibbs PE; Jenkins JL; Heimiller C; Maines MD
FASEB J; 2016 Aug; 30(8):2926-44. PubMed ID: 27166089
[TBL] [Abstract][Full Text] [Related]
9. Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1.
Xie Z; Zeng X; Waldman T; Glazer RI
Cancer Res; 2003 Sep; 63(17):5370-5. PubMed ID: 14500370
[TBL] [Abstract][Full Text] [Related]
10. The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells.
Neri LM; Borgatti P; Tazzari PL; Bortul R; Cappellini A; Tabellini G; Bellacosa A; Capitani S; Martelli AM
Mol Cancer Res; 2003 Jan; 1(3):234-46. PubMed ID: 12556562
[TBL] [Abstract][Full Text] [Related]
11. Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.
Ng SSW ; Tsao MS; Chow S; Hedley DW
Cancer Res; 2000 Oct; 60(19):5451-5. PubMed ID: 11034087
[TBL] [Abstract][Full Text] [Related]
12. Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells.
Yi YW; Kang HJ; Kim HJ; Hwang JS; Wang A; Bae I
Mol Carcinog; 2013 Sep; 52(9):667-75. PubMed ID: 22488590
[TBL] [Abstract][Full Text] [Related]
13. 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.
Maurer M; Su T; Saal LH; Koujak S; Hopkins BD; Barkley CR; Wu J; Nandula S; Dutta B; Xie Y; Chin YR; Kim DI; Ferris JS; Gruvberger-Saal SK; Laakso M; Wang X; Memeo L; Rojtman A; Matos T; Yu JS; Cordon-Cardo C; Isola J; Terry MB; Toker A; Mills GB; Zhao JJ; Murty VV; Hibshoosh H; Parsons R
Cancer Res; 2009 Aug; 69(15):6299-306. PubMed ID: 19602588
[TBL] [Abstract][Full Text] [Related]
14. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
Clark AS; West K; Streicher S; Dennis PA
Mol Cancer Ther; 2002 Jul; 1(9):707-17. PubMed ID: 12479367
[TBL] [Abstract][Full Text] [Related]
15. A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis.
Schmidt M; Hövelmann S; Beckers TL
Br J Cancer; 2002 Oct; 87(8):924-32. PubMed ID: 12373610
[TBL] [Abstract][Full Text] [Related]
16. Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2.
Liao XH; Buggey J; Kimmel AR
J Cell Sci; 2010 Mar; 123(Pt 6):983-92. PubMed ID: 20200230
[TBL] [Abstract][Full Text] [Related]
17. Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines.
Duan Z; Duan Y; Lamendola DE; Yusuf RZ; Naeem R; Penson RT; Seiden MV
Clin Cancer Res; 2003 Jul; 9(7):2778-85. PubMed ID: 12855658
[TBL] [Abstract][Full Text] [Related]
18. COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPβ pathway and PDK1 stabilization.
Wu YH; Chang TH; Huang YF; Chen CC; Chou CY
Oncotarget; 2015 Sep; 6(27):23748-63. PubMed ID: 26087191
[TBL] [Abstract][Full Text] [Related]
19. Silencing of PDK1 gene expression by RNA interference suppresses growth of esophageal cancer.
Yu J; Chen KS; Li YN; Yang J; Zhao L
Asian Pac J Cancer Prev; 2012; 13(8):4147-51. PubMed ID: 23098536
[TBL] [Abstract][Full Text] [Related]
20. Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells.
Baxi SM; Tan W; Murphy ST; Smeal T; Yin MJ
PLoS One; 2012; 7(10):e48402. PubMed ID: 23119004
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
