BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

245 related articles for article (PubMed ID: 1678520)

  • 1. A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.
    Gros P; Dhir R; Croop J; Talbot F
    Proc Natl Acad Sci U S A; 1991 Aug; 88(16):7289-93. PubMed ID: 1678520
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.
    Kajiji S; Talbot F; Grizzuti K; Van Dyke-Phillips V; Agresti M; Safa AR; Gros P
    Biochemistry; 1993 Apr; 32(16):4185-94. PubMed ID: 7682843
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Modulatory effects on substrate specificity of independent mutations at the serine939/941 position in predicted transmembrane domain 11 of P-glycoproteins.
    Dhir R; Grizzuti K; Kajiji S; Gros P
    Biochemistry; 1993 Sep; 32(36):9492-9. PubMed ID: 8103679
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.
    Devault A; Gros P
    Mol Cell Biol; 1990 Apr; 10(4):1652-63. PubMed ID: 1969610
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein.
    Loo TW; Clarke DM
    J Biol Chem; 1993 Feb; 268(5):3143-9. PubMed ID: 8094081
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.
    Azzaria M; Schurr E; Gros P
    Mol Cell Biol; 1989 Dec; 9(12):5289-97. PubMed ID: 2573836
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.
    Tang-Wai DF; Kajiji S; DiCapua F; de Graaf D; Roninson IB; Gros P
    Biochemistry; 1995 Jan; 34(1):32-9. PubMed ID: 7819214
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Functional analysis of chimeric proteins constructed by exchanging homologous domains of two P-glycoproteins conferring distinct drug resistance profiles.
    Dhir R; Gros P
    Biochemistry; 1992 Jul; 31(26):6103-10. PubMed ID: 1352702
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structurally distinct MDR modulators show specific patterns of reversal against P-glycoproteins bearing unique mutations at serine939/941.
    Kajiji S; Dreslin JA; Grizzuti K; Gros P
    Biochemistry; 1994 May; 33(17):5041-8. PubMed ID: 8172879
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.
    Choi KH; Chen CJ; Kriegler M; Roninson IB
    Cell; 1988 May; 53(4):519-29. PubMed ID: 2897240
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural and functional characterization of the mouse multidrug resistance gene family.
    Dhir R; Buschman E; Gros P
    Bull Cancer; 1990; 77(11):1125-9. PubMed ID: 1980424
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning.
    Hanna M; Brault M; Kwan T; Kast C; Gros P
    Biochemistry; 1996 Mar; 35(11):3625-35. PubMed ID: 8639515
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.
    Safa AR; Stern RK; Choi K; Agresti M; Tamai I; Mehta ND; Roninson IB
    Proc Natl Acad Sci U S A; 1990 Sep; 87(18):7225-9. PubMed ID: 1976255
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.
    Loo TW; Clarke DM
    J Biol Chem; 1993 Sep; 268(27):19965-72. PubMed ID: 8104183
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance.
    Tang-Wai DF; Brossi A; Arnold LD; Gros P
    Biochemistry; 1993 Jun; 32(25):6470-6. PubMed ID: 8100149
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sequence of mdr3 cDNA encoding a human P-glycoprotein.
    van der Bliek AM; Kooiman PM; Schneider C; Borst P
    Gene; 1988 Nov; 71(2):401-11. PubMed ID: 2906314
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.
    Currier SJ; Kane SE; Willingham MC; Cardarelli CO; Pastan I; Gottesman MM
    J Biol Chem; 1992 Dec; 267(35):25153-9. PubMed ID: 1360983
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein.
    Ruth A; Stein WD; Rose E; Roninson IB
    Biochemistry; 2001 Apr; 40(14):4332-9. PubMed ID: 11284689
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells.
    Raymond M; Rose E; Housman DE; Gros P
    Mol Cell Biol; 1990 Apr; 10(4):1642-51. PubMed ID: 1969609
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection.
    Choi K; Frommel TO; Stern RK; Perez CF; Kriegler M; Tsuruo T; Roninson IB
    Proc Natl Acad Sci U S A; 1991 Aug; 88(16):7386-90. PubMed ID: 1678523
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.