BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

253 related articles for article (PubMed ID: 16789735)

  • 1. Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.
    Combs AP; Zhu W; Crawley ML; Glass B; Polam P; Sparks RB; Modi D; Takvorian A; McLaughlin E; Yue EW; Wasserman Z; Bower M; Wei M; Rupar M; Ala PJ; Reid BM; Ellis D; Gonneville L; Emm T; Taylor N; Yeleswaram S; Li Y; Wynn R; Burn TC; Hollis G; Liu PC; Metcalf B
    J Med Chem; 2006 Jun; 49(13):3774-89. PubMed ID: 16789735
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors.
    Sparks RB; Polam P; Zhu W; Crawley ML; Takvorian A; McLaughlin E; Wei M; Ala PJ; Gonneville L; Taylor N; Li Y; Wynn R; Burn TC; Liu PC; Combs AP
    Bioorg Med Chem Lett; 2007 Feb; 17(3):736-40. PubMed ID: 17097290
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
    Combs AP; Yue EW; Bower M; Ala PJ; Wayland B; Douty B; Takvorian A; Polam P; Wasserman Z; Zhu W; Crawley ML; Pruitt J; Sparks R; Glass B; Modi D; McLaughlin E; Bostrom L; Li M; Galya L; Blom K; Hillman M; Gonneville L; Reid BG; Wei M; Becker-Pasha M; Klabe R; Huber R; Li Y; Hollis G; Burn TC; Wynn R; Liu P; Metcalf B
    J Med Chem; 2005 Oct; 48(21):6544-8. PubMed ID: 16220970
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: synthesis and structure-activity relationships of a peptide scaffold.
    Yue EW; Wayland B; Douty B; Crawley ML; McLaughlin E; Takvorian A; Wasserman Z; Bower MJ; Wei M; Li Y; Ala PJ; Gonneville L; Wynn R; Burn TC; Liu PC; Combs AP
    Bioorg Med Chem; 2006 Sep; 14(17):5833-49. PubMed ID: 16769216
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Asymmetric synthesis of the (S)-1,1-dioxido-isothiazolidin-3-one phosphotyrosine mimetic via reduction of a homochiral (R)-oxido-isothiazolidin-3-one.
    Combs AP; Glass B; Galya LG; Li M
    Org Lett; 2007 Mar; 9(7):1279-82. PubMed ID: 17338536
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B.
    Ala PJ; Gonneville L; Hillman M; Becker-Pasha M; Yue EW; Douty B; Wayland B; Polam P; Crawley ML; McLaughlin E; Sparks RB; Glass B; Takvorian A; Combs AP; Burn TC; Hollis GF; Wynn R
    J Biol Chem; 2006 Dec; 281(49):38013-21. PubMed ID: 17028182
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
    Wilson DP; Wan ZK; Xu WX; Kirincich SJ; Follows BC; Joseph-McCarthy D; Foreman K; Moretto A; Wu J; Zhu M; Binnun E; Zhang YL; Tam M; Erbe DV; Tobin J; Xu X; Leung L; Shilling A; Tam SY; Mansour TS; Lee J
    J Med Chem; 2007 Sep; 50(19):4681-98. PubMed ID: 17705360
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.
    Liu G; Xin Z; Liang H; Abad-Zapatero C; Hajduk PJ; Janowick DA; Szczepankiewicz BG; Pei Z; Hutchins CW; Ballaron SJ; Stashko MA; Lubben TH; Berg CE; Rondinone CM; Trevillyan JM; Jirousek MR
    J Med Chem; 2003 Jul; 46(16):3437-40. PubMed ID: 12877578
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.
    Douty B; Wayland B; Ala PJ; Bower MJ; Pruitt J; Bostrom L; Wei M; Klabe R; Gonneville L; Wynn R; Burn TC; Liu PC; Combs AP; Yue EW
    Bioorg Med Chem Lett; 2008 Jan; 18(1):66-71. PubMed ID: 18037290
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors.
    Holmes CP; Li X; Pan Y; Xu C; Bhandari A; Moody CM; Miguel JA; Ferla SW; De Francisco MN; Frederick BT; Zhou S; Macher N; Jang L; Irvine JD; Grove JR
    Bioorg Med Chem Lett; 2005 Oct; 15(19):4336-41. PubMed ID: 16046123
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives.
    Stuible M; Zhao L; Aubry I; Schmidt-Arras D; Böhmer FD; Li CJ; Tremblay ML
    Chembiochem; 2007 Jan; 8(2):179-86. PubMed ID: 17191286
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition.
    Hussain M; Ahmed V; Hill B; Ahmed Z; Taylor SD
    Bioorg Med Chem; 2008 Jul; 16(14):6764-77. PubMed ID: 18555687
    [TBL] [Abstract][Full Text] [Related]  

  • 13. High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide.
    Phan J; Lee K; Cherry S; Tropea JE; Burke TR; Waugh DS
    Biochemistry; 2003 Nov; 42(45):13113-21. PubMed ID: 14609321
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.
    Liu G; Szczepankiewicz BG; Pei Z; Janowick DA; Xin Z; Hajduk PJ; Abad-Zapatero C; Liang H; Hutchins CW; Fesik SW; Ballaron SJ; Stashko MA; Lubben T; Mika AK; Zinker BA; Trevillyan JM; Jirousek MR
    J Med Chem; 2003 May; 46(11):2093-103. PubMed ID: 12747781
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives.
    Li Y; Lu L; Zhu M; Wang Q; Yuan C; Xing S; Fu X; Mei Y
    Biometals; 2011 Dec; 24(6):993-1004. PubMed ID: 21618062
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.
    Wan ZK; Lee J; Xu W; Erbe DV; Joseph-McCarthy D; Follows BC; Zhang YL
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4941-5. PubMed ID: 16806920
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
    Zhao H; Liu G; Xin Z; Serby MD; Pei Z; Szczepankiewicz BG; Hajduk PJ; Abad-Zapatero C; Hutchins CW; Lubben TH; Ballaron SJ; Haasch DL; Kaszubska W; Rondinone CM; Trevillyan JM; Jirousek MR
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5543-6. PubMed ID: 15482920
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors.
    Lee K; Boovanahalli SK; Nam KY; Kang SU; Lee M; Phan J; Wu L; Waugh DS; Zhang ZY; No KT; Lee JJ; Burke TR
    Bioorg Med Chem Lett; 2005 Sep; 15(18):4037-42. PubMed ID: 16039123
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
    Bleasdale JE; Ogg D; Palazuk BJ; Jacob CS; Swanson ML; Wang XY; Thompson DP; Conradi RA; Mathews WR; Laborde AL; Stuchly CW; Heijbel A; Bergdahl K; Bannow CA; Smith CW; Svensson C; Liljebris C; Schostarez HJ; May PD; Stevens FC; Larsen SD
    Biochemistry; 2001 May; 40(19):5642-54. PubMed ID: 11341829
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design.
    Burke TR; Ye B; Yan X; Wang S; Jia Z; Chen L; Zhang ZY; Barford D
    Biochemistry; 1996 Dec; 35(50):15989-96. PubMed ID: 8973169
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.