203 related articles for article (PubMed ID: 16789750)
1. 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.
Enguehard-Gueiffier C; Hübner H; El Hakmaoui A; Allouchi H; Gmeiner P; Argiolas A; Melis MR; Gueiffier A
J Med Chem; 2006 Jun; 49(13):3938-47. PubMed ID: 16789750
[TBL] [Abstract][Full Text] [Related]
2. PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain.
Melis MR; Succu S; Sanna F; Melis T; Mascia MS; Enguehard-Gueiffier C; Hubner H; Gmeiner P; Gueiffier A; Argiolas A
Eur J Neurosci; 2006 Oct; 24(7):2021-30. PubMed ID: 17067298
[TBL] [Abstract][Full Text] [Related]
3. S 18126 ([2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl]), a potent, selective and competitive antagonist at dopamine D4 receptors: an in vitro and in vivo comparison with L 745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-pyrrolo[2, 3b]pyridine) and raclopride.
Millan MJ; Newman-Tancredi A; Brocco M; Gobert A; Lejeune F; Audinot V; Rivet JM; Schreiber R; Dekeyne A; Spedding M; Nicolas JP; Peglion JL
J Pharmacol Exp Ther; 1998 Oct; 287(1):167-86. PubMed ID: 9765336
[TBL] [Abstract][Full Text] [Related]
4. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.
Grundt P; Carlson EE; Cao J; Bennett CJ; McElveen E; Taylor M; Luedtke RR; Newman AH
J Med Chem; 2005 Feb; 48(3):839-48. PubMed ID: 15689168
[TBL] [Abstract][Full Text] [Related]
5. 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.
Nakane M; Cowart MD; Hsieh GC; Miller L; Uchic ME; Chang R; Terranova MA; Donnelly-Roberts DL; Namovic MT; Miller TR; Wetter JM; Marsh K; Stewart AO; Brioni JD; Moreland RB
Neuropharmacology; 2005 Jul; 49(1):112-21. PubMed ID: 15992586
[TBL] [Abstract][Full Text] [Related]
6. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.
Patel S; Freedman S; Chapman KL; Emms F; Fletcher AE; Knowles M; Marwood R; Mcallister G; Myers J; Curtis N; Kulagowski JJ; Leeson PD; Ridgill M; Graham M; Matheson S; Rathbone D; Watt AP; Bristow LJ; Rupniak NM; Baskin E; Lynch JJ; Ragan CI
J Pharmacol Exp Ther; 1997 Nov; 283(2):636-47. PubMed ID: 9353380
[TBL] [Abstract][Full Text] [Related]
7. 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
Kolasa T; Matulenko MA; Hakeem AA; Patel MV; Mortell K; Bhatia P; Henry R; Nakane M; Hsieh GC; Terranova MA; Uchic ME; Miller LN; Chang R; Donnelly-Roberts DL; Namovic MT; Hollingsworth PR; Martino B; El Kouhen O; Marsh KC; Wetter JM; Moreland RB; Brioni JD; Stewart AO
J Med Chem; 2006 Aug; 49(17):5093-109. PubMed ID: 16913699
[TBL] [Abstract][Full Text] [Related]
8. Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.
Cowart M; Latshaw SP; Bhatia P; Daanen JF; Rohde J; Nelson SL; Patel M; Kolasa T; Nakane M; Uchic ME; Miller LN; Terranova MA; Chang R; Donnelly-Roberts DL; Namovic MT; Hollingsworth PR; Martino BR; Lynch JJ; Sullivan JP; Hsieh GC; Moreland RB; Brioni JD; Stewart AO
J Med Chem; 2004 Jul; 47(15):3853-64. PubMed ID: 15239663
[TBL] [Abstract][Full Text] [Related]
9. PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats.
Melis MR; Succu S; Mascia MS; Argiolas A
Neurosci Lett; 2005 Apr; 379(1):59-62. PubMed ID: 15814200
[TBL] [Abstract][Full Text] [Related]
10. N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand.
Perrone R; Berardi F; Colabufo NA; Leopoldo M; Tortorella V
J Med Chem; 1998 Nov; 41(24):4903-9. PubMed ID: 9822559
[TBL] [Abstract][Full Text] [Related]
11. A-412997 is a selective dopamine D4 receptor agonist in rats.
Moreland RB; Patel M; Hsieh GC; Wetter JM; Marsh K; Brioni JD
Pharmacol Biochem Behav; 2005 Sep; 82(1):140-7. PubMed ID: 16153699
[TBL] [Abstract][Full Text] [Related]
12. Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.
Unangst PC; Capiris T; Connor DT; Heffner TG; MacKenzie RG; Miller SR; Pugsley TA; Wise LD
J Med Chem; 1997 Aug; 40(17):2688-93. PubMed ID: 9276014
[TBL] [Abstract][Full Text] [Related]
13. Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin.
Succu S; Sanna F; Melis T; Boi A; Argiolas A; Melis MR
Neuropharmacology; 2007 Mar; 52(3):1034-43. PubMed ID: 17164075
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.
Linz S; Müller J; Hübner H; Gmeiner P; Troschütz R
Bioorg Med Chem; 2009 Jul; 17(13):4448-58. PubMed ID: 19481941
[TBL] [Abstract][Full Text] [Related]
15. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
Glennon JC; Van Scharrenburg G; Ronken E; Hesselink MB; Reinders JH; Van Der Neut M; Long SK; Feenstra RW; McCreary AC
Synapse; 2006 Dec; 60(8):599-608. PubMed ID: 17001660
[TBL] [Abstract][Full Text] [Related]
16. Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles.
Schlotter K; Boeckler F; Hübner H; Gmeiner P
J Med Chem; 2005 Jun; 48(11):3696-9. PubMed ID: 15916420
[TBL] [Abstract][Full Text] [Related]
17. Aplindore (DAB-452), a high affinity selective dopamine D2 receptor partial agonist.
Heinrich JN; Brennan J; Lai MH; Sullivan K; Hornby G; Popiolek M; Jiang LX; Pausch MH; Stack G; Marquis KL; Andree TH
Eur J Pharmacol; 2006 Dec; 552(1-3):36-45. PubMed ID: 17056032
[TBL] [Abstract][Full Text] [Related]
18. Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.
Stewart AO; Cowart MD; Moreland RB; Latshaw SP; Matulenko MA; Bhatia PA; Wang X; Daanen JF; Nelson SL; Terranova MA; Namovic MT; Donnelly-Roberts DL; Miller LN; Nakane M; Sullivan JP; Brioni JD
J Med Chem; 2004 Apr; 47(9):2348-55. PubMed ID: 15084133
[TBL] [Abstract][Full Text] [Related]
19. Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).
Löber S; Hübner H; Utz W; Gmeiner P
J Med Chem; 2001 Aug; 44(17):2691-4. PubMed ID: 11495580
[TBL] [Abstract][Full Text] [Related]
20. Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors.
Depoortère R; Bardin L; Rodrigues M; Abrial E; Aliaga M; Newman-Tancredi A
Behav Pharmacol; 2009 Jul; 20(4):303-11. PubMed ID: 19584712
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
