203 related articles for article (PubMed ID: 16814542)
1. Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1.
Rowbottom MW; Vickers TD; Dyck B; Grey J; Tamiya J; Zhang M; Kiankarimi M; Wu D; Dwight W; Wade WS; Schwarz D; Heise CE; Madan A; Fisher A; Petroski R; Goodfellow VS
Bioorg Med Chem Lett; 2006 Sep; 16(17):4450-7. PubMed ID: 16814542
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2.
Hudson S; Kiankarimi M; Rowbottom MW; Vickers TD; Wu D; Pontillo J; Ching B; Dwight W; Goodfellow VS; Schwarz D; Heise CE; Madan A; Wen J; Ban W; Wang H; Wade WS
Bioorg Med Chem Lett; 2006 Sep; 16(18):4922-30. PubMed ID: 16824755
[TBL] [Abstract][Full Text] [Related]
3. Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.
Zhang M; Tamiya J; Nguyen L; Rowbottom MW; Dyck B; Vickers TD; Grey J; Schwarz DA; Heise CE; Haelewyn J; Mistry MS; Goodfellow VS
Bioorg Med Chem Lett; 2007 May; 17(9):2535-9. PubMed ID: 17329101
[TBL] [Abstract][Full Text] [Related]
4. Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists.
Grey J; Dyck B; Rowbottom MW; Tamiya J; Vickers TD; Zhang M; Zhao L; Heise CE; Schwarz D; Saunders J; Goodfellow VS
Bioorg Med Chem Lett; 2005 Feb; 15(4):999-1004. PubMed ID: 15686900
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
Rowbottom MW; Vickers TD; Dyck B; Tamiya J; Zhang M; Zhao L; Grey J; Provencal D; Schwarz D; Heise CE; Mistry M; Fisher A; Dong T; Hu T; Saunders J; Goodfellow VS
Bioorg Med Chem Lett; 2005 Jul; 15(14):3439-45. PubMed ID: 15950467
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
Rowbottom MW; Vickers TD; Tamiya J; Zhang M; Dyck B; Grey J; Schwarz D; Heise CE; Hedrick M; Wen J; Tang H; Wang H; Fisher A; Aparicio A; Saunders J; Goodfellow VS
Bioorg Med Chem Lett; 2007 Apr; 17(8):2171-8. PubMed ID: 17350839
[TBL] [Abstract][Full Text] [Related]
7. 4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists.
Receveur JM; Bjurling E; Ulven T; Little PB; Nørregaard PK; Högberg T
Bioorg Med Chem Lett; 2004 Oct; 14(20):5075-80. PubMed ID: 15380202
[TBL] [Abstract][Full Text] [Related]
8. Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
McBriar MD; Guzik H; Shapiro S; Paruchova J; Xu R; Palani A; Clader JW; Cox K; Greenlee WJ; Hawes BE; Kowalski TJ; O'neill K; Spar BD; Weig B; Weston DJ; Farley C; Cook J
J Med Chem; 2006 Apr; 49(7):2294-310. PubMed ID: 16570926
[TBL] [Abstract][Full Text] [Related]
9. The discovery and optimization of pyrimidinone-containing MCH R1 antagonists.
Hertzog DL; Al-Barazanji KA; Bigham EC; Bishop MJ; Britt CS; Carlton DL; Cooper JP; Daniels AJ; Garrido DM; Goetz AS; Grizzle MK; Guo YC; Handlon AL; Ignar DM; Morgan RO; Peat AJ; Tavares FX; Zhou H
Bioorg Med Chem Lett; 2006 Sep; 16(18):4723-7. PubMed ID: 16870432
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists.
Wu WL; Burnett DA; Spring R; Qiang L; Sasikumar TK; Domalski MS; Greenlee WJ; O'Neill K; Hawes BE
Bioorg Med Chem Lett; 2006 Jul; 16(14):3668-73. PubMed ID: 16690312
[TBL] [Abstract][Full Text] [Related]
11. Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Rami HK; Thompson M; Stemp G; Fell S; Jerman JC; Stevens AJ; Smart D; Sargent B; Sanderson D; Randall AD; Gunthorpe MJ; Davis JB
Bioorg Med Chem Lett; 2006 Jun; 16(12):3287-91. PubMed ID: 16580202
[TBL] [Abstract][Full Text] [Related]
12. Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.
Wu WL; Burnett DA; Caplen MA; Domalski MS; Bennett C; Greenlee WJ; Hawes BE; O'Neill K; Weig B; Weston D; Spar B; Kowalski T
Bioorg Med Chem Lett; 2006 Jul; 16(14):3674-8. PubMed ID: 16690315
[TBL] [Abstract][Full Text] [Related]
13. Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis.
Su J; McKittrick BA; Tang H; Czarniecki M; Greenlee WJ; Hawes BE; O'Neill K
Bioorg Med Chem; 2005 Mar; 13(5):1829-36. PubMed ID: 15698800
[TBL] [Abstract][Full Text] [Related]
14. Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists.
Arienzo R; Clark DE; Cramp S; Daly S; Dyke HJ; Lockey P; Norman D; Roach AG; Stuttle K; Tomlinson M; Wong M; Wren SP
Bioorg Med Chem Lett; 2004 Aug; 14(15):4099-102. PubMed ID: 15225734
[TBL] [Abstract][Full Text] [Related]
15. Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists.
Ma V; Bannon AW; Baumgartner J; Hale C; Hsieh F; Hulme C; Rorrer K; Salon J; van Staden C; Tempest P
Bioorg Med Chem Lett; 2006 Oct; 16(19):5066-72. PubMed ID: 16887348
[TBL] [Abstract][Full Text] [Related]
16. Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1.
Kanuma K; Omodera K; Nishiguchi M; Funakoshi T; Chaki S; Semple G; Tran TA; Kramer B; Hsu D; Casper M; Thomsen B; Beeley N; Sekiguchi Y
Bioorg Med Chem Lett; 2005 May; 15(10):2565-9. PubMed ID: 15863317
[TBL] [Abstract][Full Text] [Related]
17. Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists.
Guo T; Gu H; Hobbs DW; Busler DE; Rokosz LL
Bioorg Med Chem Lett; 2007 Mar; 17(6):1718-21. PubMed ID: 17251014
[TBL] [Abstract][Full Text] [Related]
18. Optimization of piperidin-4-yl-urea-containing melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Reducing hERG-associated liabilities.
Berglund S; Egner BJ; Gradén H; Gradén J; Morgan DG; Inghardt T; Giordanetto F
Bioorg Med Chem Lett; 2009 Aug; 19(15):4274-9. PubMed ID: 19500982
[TBL] [Abstract][Full Text] [Related]
19. Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.
McBriar MD; Guzik H; Xu R; Paruchova J; Li S; Palani A; Clader JW; Greenlee WJ; Hawes BE; Kowalski TJ; O'Neill K; Spar B; Weig B
J Med Chem; 2005 Apr; 48(7):2274-7. PubMed ID: 15801820
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists.
Lim CJ; Kim JY; Lee BH; Oh KS; Yi KY
Bioorg Med Chem Lett; 2013 Mar; 23(6):1736-9. PubMed ID: 23411080
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
