BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

130 related articles for article (PubMed ID: 16818517)

  • 1. Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy.
    Yoon KJ; Qi J; Remack JS; Virga KG; Hatfield MJ; Potter PM; Lee RE; Danks MK
    Mol Cancer Ther; 2006 Jun; 5(6):1577-84. PubMed ID: 16818517
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies.
    Yoon KJ; Krull EJ; Morton CL; Bornmann WG; Lee RE; Potter PM; Danks MK
    Mol Cancer Ther; 2003 Nov; 2(11):1171-81. PubMed ID: 14617791
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.
    Wierdl M; Tsurkan L; Hyatt JL; Edwards CC; Hatfield MJ; Morton CL; Houghton PJ; Danks MK; Redinbo MR; Potter PM
    Cancer Gene Ther; 2008 Mar; 15(3):183-92. PubMed ID: 18188187
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy.
    Danks MK; Morton CL; Krull EJ; Cheshire PJ; Richmond LB; Naeve CW; Pawlik CA; Houghton PJ; Potter PM
    Clin Cancer Res; 1999 Apr; 5(4):917-24. PubMed ID: 10213229
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.
    Danks MK; Yoon KJ; Bush RA; Remack JS; Wierdl M; Tsurkan L; Kim SU; Garcia E; Metz MZ; Najbauer J; Potter PM; Aboody KS
    Cancer Res; 2007 Jan; 67(1):22-5. PubMed ID: 17210679
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.
    Yoon KJ; Hyatt JL; Morton CL; Lee RE; Potter PM; Danks MK
    Mol Cancer Ther; 2004 Aug; 3(8):903-9. PubMed ID: 15299073
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy.
    Shabat D; Lode HN; Pertl U; Reisfeld RA; Rader C; Lerner RA; Barbas CF
    Proc Natl Acad Sci U S A; 2001 Jun; 98(13):7528-33. PubMed ID: 11404472
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Human neural stem cell tropism to metastatic breast cancer.
    Zhao D; Najbauer J; Annala AJ; Garcia E; Metz MZ; Gutova M; Polewski MD; Gilchrist M; Glackin CA; Kim SU; Aboody KS
    Stem Cells; 2012 Feb; 30(2):314-25. PubMed ID: 22084033
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11.
    Meck MM; Wierdl M; Wagner LM; Burger RA; Guichard SM; Krull EJ; Harris LC; Potter PM; Danks MK
    Cancer Res; 2001 Jul; 61(13):5083-9. PubMed ID: 11431345
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11.
    Pawlik CA; Iyengar RV; Krull EJ; Mason SE; Khanna R; Harris LC; Potter PM; Danks MK; Guichard SM
    Mol Ther; 2000 May; 1(5 Pt 1):457-63. PubMed ID: 10933967
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Gene-directed enzyme prodrug therapy for osteosarcoma: sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2.
    Oosterhoff D; Witlox MA; van Beusechem VW; Haisma HJ; Schaap GR; Bras J; Kruyt FA; Molenaar B; Boven E; Wuisman PI; Pinedo HM; Gerritsen WR
    Mol Cancer Ther; 2003 Aug; 2(8):765-71. PubMed ID: 12939466
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11.
    Danks MK; Morton CL; Pawlik CA; Potter PM
    Cancer Res; 1998 Jan; 58(1):20-2. PubMed ID: 9426050
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Therapeutic targeting of subdural medulloblastomas using human neural stem cells expressing carboxylesterase.
    Lim SH; Choi SA; Lee JY; Wang KC; Phi JH; Lee DH; Song SH; Song JH; Jin X; Kim H; Lee HJ; Lim I; Kim SU; Kim SK
    Cancer Gene Ther; 2011 Nov; 18(11):817-24. PubMed ID: 21869821
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38.
    Stubdal H; Perin N; Lemmon M; Holman P; Bauzon M; Potter PM; Danks MK; Fattaey A; Dubensky T; Johnson L
    Cancer Res; 2003 Oct; 63(20):6900-8. PubMed ID: 14583489
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
    Oosterhoff D; Pinedo HM; van der Meulen IH; de Graaf M; Sone T; Kruyt FA; van Beusechem VW; Haisma HJ; Gerritsen WR
    Br J Cancer; 2002 Sep; 87(6):659-64. PubMed ID: 12237777
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hypoxia-targeted over-expression of carboxylesterase as a means of increasing tumour sensitivity to irinotecan (CPT-11).
    Matzow T; Cowen RL; Williams KJ; Telfer BA; Flint PJ; Southgate TD; Saunders MP
    J Gene Med; 2007 Apr; 9(4):244-52. PubMed ID: 17397102
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance.
    Wierdl M; Wall A; Morton CL; Sampath J; Danks MK; Schuetz JD; Potter PM
    Mol Pharmacol; 2003 Aug; 64(2):279-88. PubMed ID: 12869632
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug.
    Senter PD; Beam KS; Mixan B; Wahl AF
    Bioconjug Chem; 2001; 12(6):1074-80. PubMed ID: 11716702
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Enzyme-prodrug systems: carboxylesterase/CPT-11.
    Danks MK; Potter PM
    Methods Mol Med; 2004; 90():247-62. PubMed ID: 14657567
    [No Abstract]   [Full Text] [Related]  

  • 20. Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.
    Hyatt JL; Tsurkan L; Wierdl M; Edwards CC; Danks MK; Potter PM
    Mol Cancer Ther; 2006 Sep; 5(9):2281-8. PubMed ID: 16985062
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.