189 related articles for article (PubMed ID: 16827559)
21. Tetramic and tetronic acids: an update on new derivatives and biological aspects.
Schobert R; Schlenk A
Bioorg Med Chem; 2008 Apr; 16(8):4203-21. PubMed ID: 18334299
[TBL] [Abstract][Full Text] [Related]
22. Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Cole DC; Stock JR; Chopra R; Cowling R; Ellingboe JW; Fan KY; Harrison BL; Hu Y; Jacobsen S; Jennings LD; Jin G; Lohse PA; Malamas MS; Manas ES; Moore WJ; O'Donnell MM; Olland AM; Robichaud AJ; Svenson K; Wu J; Wagner E; Bard J
Bioorg Med Chem Lett; 2008 Feb; 18(3):1063-6. PubMed ID: 18162398
[TBL] [Abstract][Full Text] [Related]
23. Apo and inhibitor complex structures of BACE (beta-secretase).
Patel S; Vuillard L; Cleasby A; Murray CW; Yon J
J Mol Biol; 2004 Oct; 343(2):407-16. PubMed ID: 15451669
[TBL] [Abstract][Full Text] [Related]
24. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
[TBL] [Abstract][Full Text] [Related]
25. Alzheimer's disease: from pathology to therapeutic approaches.
Jakob-Roetne R; Jacobsen H
Angew Chem Int Ed Engl; 2009; 48(17):3030-59. PubMed ID: 19330877
[TBL] [Abstract][Full Text] [Related]
26. Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.
Piazzi L; Cavalli A; Colizzi F; Belluti F; Bartolini M; Mancini F; Recanatini M; Andrisano V; Rampa A
Bioorg Med Chem Lett; 2008 Jan; 18(1):423-6. PubMed ID: 17998161
[TBL] [Abstract][Full Text] [Related]
27. Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.
Garino C; Tomita T; Pietrancosta N; Laras Y; Rosas R; Herbette G; Maigret B; Quéléver G; Iwatsubo T; Kraus JL
J Med Chem; 2006 Jul; 49(14):4275-85. PubMed ID: 16821787
[TBL] [Abstract][Full Text] [Related]
28. Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.
Thompson LA; Liauw AY; Ramanjulu MM; Kasireddy-Polam P; Mercer SE; Maduskuie TP; Glicksman M; Roach AH; Meredith JE; Liu RQ; Combs AP; Higaki JN; Cordell B; Seiffert D; Zaczek RC; Robertson DW; Olson RE
Bioorg Med Chem Lett; 2006 May; 16(9):2357-63. PubMed ID: 16473009
[TBL] [Abstract][Full Text] [Related]
29. Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).
Fernández-Bachiller MI; Horatscheck A; Lisurek M; Rademann J
ChemMedChem; 2013 Jul; 8(7):1041-56. PubMed ID: 23757181
[TBL] [Abstract][Full Text] [Related]
30. Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Bihel F; Das C; Bowman MJ; Wolfe MS
J Med Chem; 2004 Jul; 47(16):3931-3. PubMed ID: 15267231
[TBL] [Abstract][Full Text] [Related]
31. Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex.
Rojo I; Martín JA; Broughton H; Timm D; Erickson J; Yang HC; McCarthy JR
Bioorg Med Chem Lett; 2006 Jan; 16(1):191-5. PubMed ID: 16249081
[TBL] [Abstract][Full Text] [Related]
32. Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting.
Rajendran L; Schneider A; Schlechtingen G; Weidlich S; Ries J; Braxmeier T; Schwille P; Schulz JB; Schroeder C; Simons M; Jennings G; Knölker HJ; Simons K
Science; 2008 Apr; 320(5875):520-3. PubMed ID: 18436784
[TBL] [Abstract][Full Text] [Related]
33. Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease.
Kreft AF; Martone R; Porte A
J Med Chem; 2009 Oct; 52(20):6169-88. PubMed ID: 19694467
[No Abstract] [Full Text] [Related]
34. BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres.
Coburn CA; Stachel SJ; Jones KG; Steele TG; Rush DM; DiMuzio J; Pietrak BL; Lai MT; Huang Q; Lineberger J; Jin L; Munshi S; Katharine Holloway M; Espeseth A; Simon A; Hazuda D; Graham SL; Vacca JP
Bioorg Med Chem Lett; 2006 Jul; 16(14):3635-8. PubMed ID: 16690314
[TBL] [Abstract][Full Text] [Related]
35. Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.
Bäck M; Nyhlén J; Kvarnström I; Appelgren S; Borkakoti N; Jansson K; Lindberg J; Nyström S; Hallberg A; Rosenquist S; Samuelsson B
Bioorg Med Chem; 2008 Nov; 16(21):9471-86. PubMed ID: 18842420
[TBL] [Abstract][Full Text] [Related]
36. Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease.
Silvestri R
Med Res Rev; 2009 Mar; 29(2):295-338. PubMed ID: 18651582
[TBL] [Abstract][Full Text] [Related]
37. A method for induced-fit docking, scoring, and ranking of flexible ligands. Application to peptidic and pseudopeptidic beta-secretase (BACE 1) inhibitors.
Moitessier N; Therrien E; Hanessian S
J Med Chem; 2006 Oct; 49(20):5885-94. PubMed ID: 17004704
[TBL] [Abstract][Full Text] [Related]
38. Design of potent inhibitors of human beta-secretase. Part 2.
Freskos JN; Fobian YM; Benson TE; Moon JB; Bienkowski MJ; Brown DL; Emmons TL; Heintz R; Laborde A; McDonald JJ; Mischke BV; Molyneaux JM; Mullins PB; Bryan Prince D; Paddock DJ; Tomasselli AG; Winterrowd G
Bioorg Med Chem Lett; 2007 Jan; 17(1):78-81. PubMed ID: 17049233
[TBL] [Abstract][Full Text] [Related]
39. Progress toward the discovery and development of efficacious BACE inhibitors.
Durham TB; Shepherd TA
Curr Opin Drug Discov Devel; 2006 Nov; 9(6):776-91. PubMed ID: 17117686
[TBL] [Abstract][Full Text] [Related]
40. Computational approaches to the prediction of blood-brain barrier permeability: A comparative analysis of central nervous system drugs versus secretase inhibitors for Alzheimer's disease.
Rishton GM; LaBonte K; Williams AJ; Kassam K; Kolovanov E
Curr Opin Drug Discov Devel; 2006 May; 9(3):303-13. PubMed ID: 16729726
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
