BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 16839761)

  • 1. SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.
    Witty DR; Bateson JH; Hervieu GJ; Jeffrey P; Johnson CN; Muir AI; O'Hanlon PJ; Stemp G; Stevens AJ; Thewlis KM; Wilson S; Winborn KY
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4865-71. PubMed ID: 16839761
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849.
    Witty DR; Bateson J; Hervieu GJ; Al-Barazanji K; Jeffrey P; Hamprecht D; Haynes A; Johnson CN; Muir AI; O'Hanlon PJ; Stemp G; Stevens AJ; Thewlis K; Winborn KY
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4872-8. PubMed ID: 16839763
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.
    Berglund S; Egner BJ; Gradén H; Gradén J; Morgan DG; Inghardt T; Giordanetto F
    Bioorg Med Chem Lett; 2008 Sep; 18(17):4859-63. PubMed ID: 18682323
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.
    Palani A; Shapiro S; McBriar MD; Clader JW; Greenlee WJ; O'Neill K; Hawes B
    Bioorg Med Chem Lett; 2005 Dec; 15(23):5234-6. PubMed ID: 16202583
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.
    Cavasotto CN; Orry AJ; Murgolo NJ; Czarniecki MF; Kocsi SA; Hawes BE; O'Neill KA; Hine H; Burton MS; Voigt JH; Abagyan RA; Bayne ML; Monsma FJ
    J Med Chem; 2008 Feb; 51(3):581-8. PubMed ID: 18198821
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.
    Lim CJ; Kim N; Lee EK; Lee BH; Oh KS; Yoo SE; Yi KY
    Bioorg Med Chem Lett; 2011 Apr; 21(8):2309-12. PubMed ID: 21420863
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.
    Clark DE; Higgs C; Wren SP; Dyke HJ; Wong M; Norman D; Lockey PM; Roach AG
    J Med Chem; 2004 Jul; 47(16):3962-71. PubMed ID: 15267235
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.
    Angell RM; Angell TD; Bamborough P; Brown D; Brown M; Buckton JB; Cockerill SG; Edwards CD; Jones KL; Longstaff T; Smee PA; Smith KJ; Somers DO; Walker AL; Willson M
    Bioorg Med Chem Lett; 2008 Jan; 18(1):324-8. PubMed ID: 17981461
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel series of substituted biphenylmethyl urea derivatives as MCH-R1 antagonists for the treatment of obesity.
    Galiano S; Ceras J; Cirauqui N; Pérez S; Juanenea L; Rivera G; Aldana I; Monge A
    Bioorg Med Chem; 2007 Jun; 15(11):3896-911. PubMed ID: 17407817
    [TBL] [Abstract][Full Text] [Related]  

  • 10. New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
    Cirauqui N; Ceras J; Galiano S; Pérez-Silanes S; Juanenea L; Rivera G; Aldana I; Monge A
    Arzneimittelforschung; 2008; 58(11):585-91. PubMed ID: 19137910
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists.
    Kanuma K; Omodera K; Nishiguchi M; Funakoshi T; Chaki S; Nagase Y; Iida I; Yamaguchi J; Semple G; Tran TA; Sekiguchi Y
    Bioorg Med Chem; 2006 May; 14(10):3307-19. PubMed ID: 16434202
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists.
    Ma V; Bannon AW; Baumgartner J; Hale C; Hsieh F; Hulme C; Rorrer K; Salon J; van Staden C; Tempest P
    Bioorg Med Chem Lett; 2006 Oct; 16(19):5066-72. PubMed ID: 16887348
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potent, selective MCH-1 receptor antagonists.
    Erickson SD; Banner B; Berthel S; Conde-Knape K; Falcioni F; Hakimi I; Hennessy B; Kester RF; Kim K; Ma C; McComas W; Mennona F; Mischke S; Orzechowski L; Qian Y; Salari H; Tengi J; Thakkar K; Taub R; Tilley JW; Wang H
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1402-6. PubMed ID: 18243691
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.
    Suzuki T; Moriya M; Sakamoto T; Suga T; Kishino H; Takahashi H; Ishikawa M; Nagai K; Imai Y; Sekino E; Ito M; Iwaasa H; Ishihara A; Tokita S; Kanatani A; Sato N; Fukami T
    Bioorg Med Chem Lett; 2009 Jun; 19(11):3072-7. PubMed ID: 19403308
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
    McBriar MD; Guzik H; Shapiro S; Paruchova J; Xu R; Palani A; Clader JW; Cox K; Greenlee WJ; Hawes BE; Kowalski TJ; O'neill K; Spar BD; Weig B; Weston DJ; Farley C; Cook J
    J Med Chem; 2006 Apr; 49(7):2294-310. PubMed ID: 16570926
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists.
    Giordanetto F; Karlsson O; Lindberg J; Larsson LO; Linusson A; Evertsson E; Morgan DG; Inghardt T
    Bioorg Med Chem Lett; 2007 Aug; 17(15):4232-41. PubMed ID: 17532215
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.
    Meyers KM; Kim N; Méndez-Andino JL; Hu XE; Mumin RN; Klopfenstein SR; Wos JA; Mitchell MC; Paris JL; Ackley DC; Holbert JK; Mittelstadt SW; Reizes O
    Bioorg Med Chem Lett; 2007 Feb; 17(3):814-8. PubMed ID: 17107791
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Biphenyl amides and isosteres as MCH R1 antagonists.
    Hertzog DL; Witty DR
    Curr Top Med Chem; 2007; 7(15):1455-70. PubMed ID: 17897032
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment?
    Högberg T; Frimurer TM; Sasmal PK
    Bioorg Med Chem Lett; 2012 Oct; 22(19):6039-47. PubMed ID: 22954736
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.
    Zhang M; Tamiya J; Nguyen L; Rowbottom MW; Dyck B; Vickers TD; Grey J; Schwarz DA; Heise CE; Haelewyn J; Mistry MS; Goodfellow VS
    Bioorg Med Chem Lett; 2007 May; 17(9):2535-9. PubMed ID: 17329101
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.