These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

106 related articles for article (PubMed ID: 16839764)

  • 1. A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).
    Bach P; Nilsson K; Wållberg A; Bauer U; Hammerland LG; Peterson A; Svensson T; Osterlund K; Karis D; Boije M; Wensbo D
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4792-5. PubMed ID: 16839764
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5).
    Bach P; Nilsson K; Svensson T; Bauer U; Hammerland LG; Peterson A; Wållberg A; Osterlund K; Karis D; Boije M; Wensbo D
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4788-91. PubMed ID: 16837196
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-activity relationships of fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyloxime (ABP688) derivatives and the discovery of a high affinity analogue as a potential candidate for imaging metabotropic glutamate recepors subtype 5 (mGluR5) with positron emission tomography (PET).
    Baumann CA; Mu L; Johannsen S; Honer M; Schubiger PA; Ametamey SM
    J Med Chem; 2010 May; 53(10):4009-17. PubMed ID: 20411954
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist.
    Ito S; Satoh A; Nagatomi Y; Hirata Y; Suzuki G; Kimura T; Satow A; Maehara S; Hikichi H; Hata M; Kawamoto H; Ohta H
    Bioorg Med Chem; 2008 Nov; 16(22):9817-29. PubMed ID: 18849168
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-activity relationships for negative allosteric mGluR5 modulators.
    Kaae BH; Harpsøe K; Kvist T; Mathiesen JM; Mølck C; Gloriam D; Jimenez HN; Uberti MA; Nielsen SM; Nielsen B; Bräuner-Osborne H; Sauerberg P; Clausen RP; Madsen U
    ChemMedChem; 2012 Mar; 7(3):440-51. PubMed ID: 22267204
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues.
    Wållberg A; Nilsson K; Osterlund K; Peterson A; Elg S; Raboisson P; Bauer U; Hammerland LG; Mattsson JP
    Bioorg Med Chem Lett; 2006 Mar; 16(5):1142-5. PubMed ID: 16380255
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
    Bonnefous C; Vernier JM; Hutchinson JH; Chung J; Reyes-Manalo G; Kamenecka T
    Bioorg Med Chem Lett; 2005 Feb; 15(4):1197-200. PubMed ID: 15686941
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Phenylethynyl-pyrrolo[1,2-a]pyrazine: a new potent and selective tool in the mGluR5 antagonists arena.
    Micheli F; Bertani B; Bozzoli A; Crippa L; Cavanni P; Di Fabio R; Donati D; Marzorati P; Merlo G; Paio A; Perugini L; Zarantonello P
    Bioorg Med Chem Lett; 2008 Mar; 18(6):1804-9. PubMed ID: 18304814
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.
    Mølck C; Harpsøe K; Gloriam DE; Clausen RP; Madsen U; Pedersen LØ; Jimenez HN; Nielsen SM; Mathiesen JM; Bräuner-Osborne H
    Mol Pharmacol; 2012 Nov; 82(5):929-37. PubMed ID: 22899869
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.
    Ritzén A; Sindet R; Hentzer M; Svendsen N; Brodbeck RM; Bundgaard C
    Bioorg Med Chem Lett; 2009 Jun; 19(12):3275-8. PubMed ID: 19443216
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.
    Kulkarni SS; Zou MF; Cao J; Deschamps JR; Rodriguez AL; Conn PJ; Newman AH
    J Med Chem; 2009 Jun; 52(11):3563-75. PubMed ID: 19445453
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5).
    Tasler S; Kraus J; Pegoraro S; Aschenbrenner A; Poggesi E; Testa R; Motta G; Leonardi A
    Bioorg Med Chem Lett; 2005 Jun; 15(11):2876-80. PubMed ID: 15878659
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.
    Tehrani LR; Smith ND; Huang D; Poon SF; Roppe JR; Seiders TJ; Chapman DF; Chung J; Cramer M; Cosford ND
    Bioorg Med Chem Lett; 2005 Nov; 15(22):5061-4. PubMed ID: 16183275
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.
    Hammerland LG; Johansson M; Malmström J; Mattsson JP; Minidis AB; Nilsson K; Peterson A; Wensbo D; Wållberg A; Osterlund K
    Bioorg Med Chem Lett; 2006 May; 16(9):2467-9. PubMed ID: 16481165
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.
    Sasikumar TK; Qiang L; Burnett DA; Greenlee WJ; Li C; Heimark L; Pramanik B; Grilli M; Bertorelli R; Lozza G; Reggiani A
    Bioorg Med Chem Lett; 2009 Jun; 19(12):3199-203. PubMed ID: 19433355
    [TBL] [Abstract][Full Text] [Related]  

  • 16. From pyrroles to pyrrolo[1,2-a]pyrazinones: a new class of mGluR1 antagonists.
    Micheli F; Cavanni P; Di Fabio R; Marchioro C; Donati D; Faedo S; Maffeis M; Sabbatini FM; Tranquillini ME
    Bioorg Med Chem Lett; 2006 Mar; 16(5):1342-5. PubMed ID: 16337118
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
    Poon SF; Eastman BW; Chapman DF; Chung J; Cramer M; Holtz G; Cosford ND; Smith ND
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5477-80. PubMed ID: 15482907
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Efficacy switching SAR of mGluR5 allosteric modulators: highly potent positive and negative modulators from one chemotype.
    Sams AG; Mikkelsen GK; Brodbeck RM; Pu X; Ritzén A
    Bioorg Med Chem Lett; 2011 Jun; 21(11):3407-10. PubMed ID: 21531137
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.
    Tresadern G; Cid JM; Macdonald GJ; Vega JA; de Lucas AI; García A; Matesanz E; Linares ML; Oehlrich D; Lavreysen H; Biesmans I; Trabanco AA
    Bioorg Med Chem Lett; 2010 Jan; 20(1):175-9. PubMed ID: 19932615
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction.
    Carroll FI
    Ann N Y Acad Sci; 2008 Oct; 1141():221-32. PubMed ID: 18991960
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.