BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

207 related articles for article (PubMed ID: 16841955)

  • 1. Future of toxicology-metabolic activation and drug design: challenges and opportunities in chemical toxicology.
    Baillie TA
    Chem Res Toxicol; 2006 Jul; 19(7):889-93. PubMed ID: 16841955
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions.
    Kumar S; Kassahun K; Tschirret-Guth RA; Mitra K; Baillie TA
    Curr Opin Drug Discov Devel; 2008 Jan; 11(1):43-52. PubMed ID: 18175266
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Approaches for minimizing metabolic activation of new drug candidates in drug discovery.
    Kumar S; Mitra K; Kassahun K; Baillie TA
    Handb Exp Pharmacol; 2010; (196):511-44. PubMed ID: 20020275
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural alerts, reactive metabolites, and protein covalent binding: how reliable are these attributes as predictors of drug toxicity?
    Kalgutkar AS; Didiuk MT
    Chem Biodivers; 2009 Nov; 6(11):2115-37. PubMed ID: 19937848
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biochemical toxicology of chemical teratogenesis.
    Wells PG; Winn LM
    Crit Rev Biochem Mol Biol; 1996 Feb; 31(1):1-40. PubMed ID: 8744954
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Analytical strategies for the screening and evaluation of chemically reactive drug metabolites.
    Wen B; Fitch WL
    Expert Opin Drug Metab Toxicol; 2009 Jan; 5(1):39-55. PubMed ID: 19236228
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [Development of antituberculous drugs: current status and future prospects].
    Tomioka H; Namba K
    Kekkaku; 2006 Dec; 81(12):753-74. PubMed ID: 17240921
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates.
    Kramer JA; Sagartz JE; Morris DL
    Nat Rev Drug Discov; 2007 Aug; 6(8):636-49. PubMed ID: 17643090
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry.
    Ma S; Subramanian R
    J Mass Spectrom; 2006 Sep; 41(9):1121-39. PubMed ID: 16967439
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Toxicophores: groups and metabolic routes associated with increased safety risk.
    Williams DP; Naisbitt DJ
    Curr Opin Drug Discov Devel; 2002 Jan; 5(1):104-15. PubMed ID: 11865664
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.
    Evans DC; Watt AP; Nicoll-Griffith DA; Baillie TA
    Chem Res Toxicol; 2004 Jan; 17(1):3-16. PubMed ID: 14727914
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Strategies for dealing with reactive intermediates in drug discovery and development.
    Nassar AE; Lopez-Anaya A
    Curr Opin Drug Discov Devel; 2004 Jan; 7(1):126-36. PubMed ID: 14982156
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Future of toxicology--mechanisms of toxicity and drug safety: where do we go from here?
    Stevens JL
    Chem Res Toxicol; 2006 Nov; 19(11):1393-401. PubMed ID: 17112225
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Opportunities and challenges in the discovery of new central nervous system drugs.
    Krause JE; Chenard BL
    Ann N Y Acad Sci; 2008 Nov; 1144():243-50. PubMed ID: 19076381
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Idiosyncratic toxicity: mechanistic insights gained from analysis of prior compounds.
    Waring JF; Anderson MG
    Curr Opin Drug Discov Devel; 2005 Jan; 8(1):59-65. PubMed ID: 15679173
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N; Makino C; Murayama N
    Chem Res Toxicol; 2007 Mar; 20(3):455-64. PubMed ID: 17309281
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Investigation of toxic metabolites during drug development.
    Park K; Williams DP; Naisbitt DJ; Kitteringham NR; Pirmohamed M
    Toxicol Appl Pharmacol; 2005 Sep; 207(2 Suppl):425-34. PubMed ID: 15996699
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Idiosyncratic drug reactions: past, present, and future.
    Uetrecht J
    Chem Res Toxicol; 2008 Jan; 21(1):84-92. PubMed ID: 18052104
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Minimizing the potential for metabolic activation as an integral part of drug design.
    Evans DC; Baillie TA
    Curr Opin Drug Discov Devel; 2005 Jan; 8(1):44-50. PubMed ID: 15679171
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Approaches to the assessment of stable and chemically reactive drug metabolites in early clinical trials.
    Baillie TA
    Chem Res Toxicol; 2009 Feb; 22(2):263-6. PubMed ID: 19216579
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.