BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

341 related articles for article (PubMed ID: 16846239)

  • 1. Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells.
    Zhang L; Cooper AJ; Krasnikov BF; Xu H; Bubber P; Pinto JT; Gibson GE; Hanigan MH
    Biochemistry; 2006 Jul; 45(29):8959-71. PubMed ID: 16846239
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Role of cysteine S-conjugate beta-lyase in the metabolism of cisplatin.
    Zhang L; Hanigan MH
    J Pharmacol Exp Ther; 2003 Sep; 306(3):988-94. PubMed ID: 12750429
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism.
    Cooper AJ; Bruschi SA; Anders MW
    Biochem Pharmacol; 2002 Aug; 64(4):553-64. PubMed ID: 12167474
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Beta-lyase-dependent attenuation of cisplatin-mediated toxicity by selenocysteine Se-conjugates in renal tubular cell lines.
    Rooseboom M; Schaaf G; Commandeur JN; Vermeulen NP; Fink-Gremmels J
    J Pharmacol Exp Ther; 2002 Jun; 301(3):884-92. PubMed ID: 12023515
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice.
    Townsend DM; Hanigan MH
    J Pharmacol Exp Ther; 2002 Jan; 300(1):142-8. PubMed ID: 11752109
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-L-cysteine.
    Park LC; Gibson GE; Bunik V; Cooper AJ
    Biochem Pharmacol; 1999 Nov; 58(10):1557-65. PubMed ID: 10535746
    [TBL] [Abstract][Full Text] [Related]  

  • 7. L-alanine-glyoxylate aminotransferase II of rat kidney and liver mitochondria possesses cysteine S-conjugate beta-lyase activity: a contributing factor to the nephrotoxicity/hepatotoxicity of halogenated alkenes?
    Cooper AJ; Krasnikov BF; Okuno E; Jeitner TM
    Biochem J; 2003 Nov; 376(Pt 1):169-78. PubMed ID: 12859250
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine.
    Elfarra AA; Lash LH; Anders MW
    Mol Pharmacol; 1987 Feb; 31(2):208-12. PubMed ID: 3807895
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Possible role of cysteine-S-conjugate β-lyase in species differences in cisplatin nephrotoxicity.
    Katayama R; Nagata S; Iida H; Yamagishi N; Yamashita T; Furuhama K
    Food Chem Toxicol; 2011 Sep; 49(9):2053-9. PubMed ID: 21640784
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells.
    Townsend DM; Deng M; Zhang L; Lapus MG; Hanigan MH
    J Am Soc Nephrol; 2003 Jan; 14(1):1-10. PubMed ID: 12506132
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mitochondrial aspartate aminotransferase catalyses cysteine S-conjugate beta-lyase reactions.
    Cooper AJ; Bruschi SA; Iriarte A; Martinez-Carrion M
    Biochem J; 2002 Nov; 368(Pt 1):253-61. PubMed ID: 12137566
    [TBL] [Abstract][Full Text] [Related]  

  • 12. High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin.
    Townsend DM; Marto JA; Deng M; Macdonald TJ; Hanigan MH
    Drug Metab Dispos; 2003 Jun; 31(6):705-13. PubMed ID: 12756201
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide.
    Lash LH; Sausen PJ; Duescher RJ; Cooley AJ; Elfarra AA
    J Pharmacol Exp Ther; 1994 Apr; 269(1):374-83. PubMed ID: 8169843
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cellular effects of reactive intermediates: nephrotoxicity of S-conjugates of amino acids.
    Anders MW; Elfarra AA; Lash LH
    Arch Toxicol; 1987; 60(1-3):103-8. PubMed ID: 3304202
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine.
    James EA; Gygi SP; Adams ML; Pierce RH; Fausto N; Aebersold RH; Nelson SD; Bruschi SA
    Biochemistry; 2002 May; 41(21):6789-97. PubMed ID: 12022883
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate beta-lyases, but turnover leads to inactivation.
    Cooper AJ; Bruschi SA; Conway M; Hutson SM
    Biochem Pharmacol; 2003 Jan; 65(2):181-92. PubMed ID: 12504794
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Stable transfection of LLC-PK1 cells with human microsomal glutathione S-transferase gene increases haloalkene glutathione S-conjugate formation and cytotoxicity.
    Otieno MA; Anders MW
    Biochem Biophys Res Commun; 1997 May; 234(2):481-4. PubMed ID: 9177297
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells.
    McGoldrick TA; Lock EA; Rodilla V; Hawksworth GM
    Arch Toxicol; 2003 Jul; 77(7):365-70. PubMed ID: 12700887
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells.
    Stevens J; Hayden P; Taylor G
    J Biol Chem; 1986 Mar; 261(7):3325-32. PubMed ID: 3753976
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The effects of haloalkene cysteine conjugates on cytosolic free calcium levels in LLC-PK(1) cells--studies utilising digital imaging fluorescence microscopy.
    Blackmore M; Whitwell C; Morton JK; Gray TJ; Lock EA
    Toxicology; 2002 Jun; 175(1-3):143-52. PubMed ID: 12049843
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.