BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

621 related articles for article (PubMed ID: 16880517)

  • 1. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.
    Liu S; Bekker-Jensen S; Mailand N; Lukas C; Bartek J; Lukas J
    Mol Cell Biol; 2006 Aug; 26(16):6056-64. PubMed ID: 16880517
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).
    Lindsey-Boltz LA; Sancar A
    J Biol Chem; 2011 Jun; 286(22):19229-36. PubMed ID: 21502314
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
    Tuul M; Kitao H; Iimori M; Matsuoka K; Kiyonari S; Saeki H; Oki E; Morita M; Maehara Y
    PLoS One; 2013; 8(2):e55361. PubMed ID: 23383325
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.
    Lindsey-Boltz LA; Serçin O; Choi JH; Sancar A
    J Biol Chem; 2009 Nov; 284(48):33107-14. PubMed ID: 19828454
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1.
    Bennett LN; Larkin C; Gillespie DA; Clarke PR
    Biochem Biophys Res Commun; 2008 May; 369(3):973-6. PubMed ID: 18331829
    [TBL] [Abstract][Full Text] [Related]  

  • 6. ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage.
    Sørensen CS; Syljuåsen RG; Lukas J; Bartek J
    Cell Cycle; 2004 Jul; 3(7):941-5. PubMed ID: 15190204
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interaction between Rad9-Hus1-Rad1 and TopBP1 activates ATR-ATRIP and promotes TopBP1 recruitment to sites of UV-damage.
    Ohashi E; Takeishi Y; Ueda S; Tsurimoto T
    DNA Repair (Amst); 2014 Sep; 21():1-11. PubMed ID: 25091155
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.
    Liu Y; Fang Y; Shao H; Lindsey-Boltz L; Sancar A; Modrich P
    J Biol Chem; 2010 Feb; 285(8):5974-82. PubMed ID: 20029092
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.
    Choi JH; Lindsey-Boltz LA; Kemp M; Mason AC; Wold MS; Sancar A
    Proc Natl Acad Sci U S A; 2010 Aug; 107(31):13660-5. PubMed ID: 20616048
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts.
    Smith-Roe SL; Patel SS; Zhou Y; Simpson DA; Rao S; Ibrahim JG; Cordeiro-Stone M; Kaufmann WK
    Cell Cycle; 2013 Jan; 12(2):332-45. PubMed ID: 23255133
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.
    Kumagai A; Kim SM; Dunphy WG
    J Biol Chem; 2004 Nov; 279(48):49599-608. PubMed ID: 15371427
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer.
    Liu K; Graves JD; Lin FT; Lin WC
    J Biol Chem; 2021; 296():100382. PubMed ID: 33556369
    [TBL] [Abstract][Full Text] [Related]  

  • 13. RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.
    Lindsey-Boltz LA; Kemp MG; Capp C; Sancar A
    Cell Cycle; 2015; 14(1):99-108. PubMed ID: 25602520
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.
    Kemp MG; Akan Z; Yilmaz S; Grillo M; Smith-Roe SL; Kang TH; Cordeiro-Stone M; Kaufmann WK; Abraham RT; Sancar A; Unsal-Kaçmaz K
    J Biol Chem; 2010 May; 285(22):16562-71. PubMed ID: 20233725
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.
    Wang X; Zou L; Lu T; Bao S; Hurov KE; Hittelman WN; Elledge SJ; Li L
    Mol Cell; 2006 Aug; 23(3):331-41. PubMed ID: 16885023
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation.
    Bennett LN; Clarke PR
    FEBS Lett; 2006 Jul; 580(17):4176-81. PubMed ID: 16828751
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation.
    Jeong SY; Kumagai A; Lee J; Dunphy WG
    J Biol Chem; 2003 Nov; 278(47):46782-8. PubMed ID: 12963733
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks.
    Lee EM; Trinh TT; Shim HJ; Park SY; Nguyen TT; Kim MJ; Song YH
    DNA Repair (Amst); 2012 Sep; 11(9):741-52. PubMed ID: 22796626
    [TBL] [Abstract][Full Text] [Related]  

  • 19. DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response.
    Lin YF; Shih HY; Shang Z; Matsunaga S; Chen BP
    Nucleic Acids Res; 2014 Apr; 42(7):4463-73. PubMed ID: 24500207
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.
    Lee J; Kumagai A; Dunphy WG
    Mol Cell; 2003 Feb; 11(2):329-40. PubMed ID: 12620222
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 32.