BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

450 related articles for article (PubMed ID: 16882880)

  • 1. Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1.
    Martínez-Jiménez CP; Castell JV; Gómez-Lechón MJ; Jover R
    Mol Pharmacol; 2006 Nov; 70(5):1681-92. PubMed ID: 16882880
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.
    Martínez-Jiménez CP; Gómez-Lechón MJ; Castell JV; Jover R
    J Biol Chem; 2006 Oct; 281(40):29840-9. PubMed ID: 16891307
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
    Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
    Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.
    Surapureddi S; Rana R; Reddy JK; Goldstein JA
    Mol Pharmacol; 2008 Sep; 74(3):913-23. PubMed ID: 18552123
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Two novel cis-elements involved in hepatocyte nuclear factor 4α regulation of acyl-coenzyme A:cholesterol acyltransferase 2 expression.
    Zhang Z; Liu J; Xi Y; Yang R; Chen H; Li Z; Liu D; Liang C
    Acta Biochim Biophys Sin (Shanghai); 2012 Feb; 44(2):162-71. PubMed ID: 22155889
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Modulation of hepatocyte nuclear factor-4alpha function by the peroxisome-proliferator-activated receptor-gamma co-activator-1alpha in the acute-phase response.
    Wang Z; Burke PA
    Biochem J; 2008 Oct; 415(2):289-96. PubMed ID: 18510493
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha.
    Itoh M; Nakajima M; Higashi E; Yoshida R; Nagata K; Yamazoe Y; Yokoi T
    J Pharmacol Exp Ther; 2006 Nov; 319(2):693-702. PubMed ID: 16857725
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.
    Rulcova A; Krausova L; Smutny T; Vrzal R; Dvorak Z; Jover R; Pavek P
    Pharmacol Rep; 2013; 65(5):1322-35. PubMed ID: 24399729
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX-1).
    Li M; Yang Y; He ZX; Zhou ZW; Yang T; Guo P; Zhang X; Zhou SF
    Drug Metab Dispos; 2014 Jan; 42(1):44-61. PubMed ID: 24104199
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T; Chiang JY
    Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hepatocyte nuclear factor-4alpha regulates the human apolipoprotein AV gene: identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-gamma coactivator-1alpha, AMP-activated protein kinase, and mitogen-activated protein kinase pathway.
    Prieur X; Schaap FG; Coste H; Rodríguez JC
    Mol Endocrinol; 2005 Dec; 19(12):3107-25. PubMed ID: 16051671
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2.
    Wiwi CA; Waxman DJ
    J Biol Chem; 2005 Feb; 280(5):3259-68. PubMed ID: 15539409
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Involvement of hepatocyte nuclear factor 4alpha in the different expression level between CYP2C9 and CYP2C19 in the human liver.
    Kawashima S; Kobayashi K; Takama K; Higuchi T; Furihata T; Hosokawa M; Chiba K
    Drug Metab Dispos; 2006 Jun; 34(6):1012-8. PubMed ID: 16540586
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from human hepatocyte carcinoma HepG2 cells).
    Novotna A; Doricakova A; Pavek P; Dvorak Z
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub; 2013 Sep; 157(3):214-21. PubMed ID: 23073537
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.
    Arpiainen S; Järvenpää SM; Manninen A; Viitala P; Lang MA; Pelkonen O; Hakkola J
    Toxicol Appl Pharmacol; 2008 Oct; 232(1):135-41. PubMed ID: 18602936
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter.
    Rufibach LE; Duncan SA; Battle M; Deeb SS
    J Lipid Res; 2006 Jul; 47(7):1463-77. PubMed ID: 16603721
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter.
    Onica T; Nichols K; Larin M; Ng L; Maslen A; Dvorak Z; Pascussi JM; Vilarem MJ; Maurel P; Kirby GM
    Mol Pharmacol; 2008 Feb; 73(2):451-60. PubMed ID: 17978169
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction.
    Lim YP; Kuo SC; Lai ML; Huang JD
    Pharmacogenet Genomics; 2009 Jan; 19(1):11-24. PubMed ID: 19077665
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.
    Rhee J; Inoue Y; Yoon JC; Puigserver P; Fan M; Gonzalez FJ; Spiegelman BM
    Proc Natl Acad Sci U S A; 2003 Apr; 100(7):4012-7. PubMed ID: 12651943
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation.
    Rha GB; Wu G; Shoelson SE; Chi YI
    J Biol Chem; 2009 Dec; 284(50):35165-76. PubMed ID: 19846556
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.