172 related articles for article (PubMed ID: 16884307)
1. Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.
Immormino RM; Kang Y; Chiosis G; Gewirth DT
J Med Chem; 2006 Aug; 49(16):4953-60. PubMed ID: 16884307
[TBL] [Abstract][Full Text] [Related]
2. Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
Llauger L; He H; Kim J; Aguirre J; Rosen N; Peters U; Davies P; Chiosis G
J Med Chem; 2005 Apr; 48(8):2892-905. PubMed ID: 15828828
[TBL] [Abstract][Full Text] [Related]
3. Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
Kasibhatla SR; Hong K; Biamonte MA; Busch DJ; Karjian PL; Sensintaffar JL; Kamal A; Lough RE; Brekken J; Lundgren K; Grecko R; Timony GA; Ran Y; Mansfield R; Fritz LC; Ulm E; Burrows FJ; Boehm MF
J Med Chem; 2007 Jun; 50(12):2767-78. PubMed ID: 17488003
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies.
Day JE; Sharp SY; Rowlands MG; Aherne W; Lewis W; Roe SM; Prodromou C; Pearl LH; Workman P; Moody CJ
Chemistry; 2010 Sep; 16(34):10366-72. PubMed ID: 20661961
[TBL] [Abstract][Full Text] [Related]
5. Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
Wright L; Barril X; Dymock B; Sheridan L; Surgenor A; Beswick M; Drysdale M; Collier A; Massey A; Davies N; Fink A; Fromont C; Aherne W; Boxall K; Sharp S; Workman P; Hubbard RE
Chem Biol; 2004 Jun; 11(6):775-85. PubMed ID: 15217611
[TBL] [Abstract][Full Text] [Related]
6. Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Gopalsamy A; Shi M; Golas J; Vogan E; Jacob J; Johnson M; Lee F; Nilakantan R; Petersen R; Svenson K; Chopra R; Tam MS; Wen Y; Ellingboe J; Arndt K; Boschelli F
J Med Chem; 2008 Feb; 51(3):373-5. PubMed ID: 18197612
[TBL] [Abstract][Full Text] [Related]
7. Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.
Kung PP; Funk L; Meng J; Collins M; Zhou JZ; Johnson MC; Ekker A; Wang J; Mehta P; Yin MJ; Rodgers C; Davies JF; Bayman E; Smeal T; Maegley KA; Gehring MR
Bioorg Med Chem Lett; 2008 Dec; 18(23):6273-8. PubMed ID: 18929486
[TBL] [Abstract][Full Text] [Related]
8. Inside the Hsp90 inhibitors binding mode through induced fit docking.
Lauria A; Ippolito M; Almerico AM
J Mol Graph Model; 2009 Feb; 27(6):712-22. PubMed ID: 19084447
[TBL] [Abstract][Full Text] [Related]
9. Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.
Barta TE; Veal JM; Rice JW; Partridge JM; Fadden RP; Ma W; Jenks M; Geng L; Hanson GJ; Huang KH; Barabasz AF; Foley BE; Otto J; Hall SE
Bioorg Med Chem Lett; 2008 Jun; 18(12):3517-21. PubMed ID: 18511277
[TBL] [Abstract][Full Text] [Related]
10. Orally active purine-based inhibitors of the heat shock protein 90.
Biamonte MA; Shi J; Hong K; Hurst DC; Zhang L; Fan J; Busch DJ; Karjian PL; Maldonado AA; Sensintaffar JL; Yang YC; Kamal A; Lough RE; Lundgren K; Burrows FJ; Timony GA; Boehm MF; Kasibhatla SR
J Med Chem; 2006 Jan; 49(2):817-28. PubMed ID: 16420067
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery.
Burlison JA; Blagg BS
Org Lett; 2006 Oct; 8(21):4855-8. PubMed ID: 17020320
[TBL] [Abstract][Full Text] [Related]
12. Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents.
Sekiguchi H; Muranaka K; Osada A; Ichikawa S; Matsuda A
Bioorg Med Chem; 2010 Aug; 18(15):5732-7. PubMed ID: 20609590
[TBL] [Abstract][Full Text] [Related]
13. Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.
Vilenchik M; Solit D; Basso A; Huezo H; Lucas B; He H; Rosen N; Spampinato C; Modrich P; Chiosis G
Chem Biol; 2004 Jun; 11(6):787-97. PubMed ID: 15217612
[TBL] [Abstract][Full Text] [Related]
14. Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Kreusch A; Han S; Brinker A; Zhou V; Choi HS; He Y; Lesley SA; Caldwell J; Gu XJ
Bioorg Med Chem Lett; 2005 Mar; 15(5):1475-8. PubMed ID: 15713410
[TBL] [Abstract][Full Text] [Related]
15. Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
He H; Zatorska D; Kim J; Aguirre J; Llauger L; She Y; Wu N; Immormino RM; Gewirth DT; Chiosis G
J Med Chem; 2006 Jan; 49(1):381-90. PubMed ID: 16392823
[TBL] [Abstract][Full Text] [Related]
16. Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors.
Bargiotti A; Musso L; Dallavalle S; Merlini L; Gallo G; Ciacci A; Giannini G; Cabri W; Penco S; Vesci L; Castorina M; Milazzo FM; Cervoni ML; Barbarino M; Pisano C; Giommarelli C; Zuco V; De Cesare M; Zunino F
Eur J Med Chem; 2012 Jul; 53():64-75. PubMed ID: 22538015
[TBL] [Abstract][Full Text] [Related]
17. Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90.
Shin SC; El-Damasy AK; Lee JH; Seo SH; Kim JH; Seo YH; Lee Y; Yu JH; Bang EK; Kim EE; Keum G
Int J Mol Sci; 2020 Dec; 21(24):. PubMed ID: 33317068
[TBL] [Abstract][Full Text] [Related]
18. 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
Brough PA; Aherne W; Barril X; Borgognoni J; Boxall K; Cansfield JE; Cheung KM; Collins I; Davies NG; Drysdale MJ; Dymock B; Eccles SA; Finch H; Fink A; Hayes A; Howes R; Hubbard RE; James K; Jordan AM; Lockie A; Martins V; Massey A; Matthews TP; McDonald E; Northfield CJ; Pearl LH; Prodromou C; Ray S; Raynaud FI; Roughley SD; Sharp SY; Surgenor A; Walmsley DL; Webb P; Wood M; Workman P; Wright L
J Med Chem; 2008 Jan; 51(2):196-218. PubMed ID: 18020435
[TBL] [Abstract][Full Text] [Related]
19. Exploring the binding site of C-terminal hsp90 inhibitors.
Sgobba M; Forestiero R; Degliesposti G; Rastelli G
J Chem Inf Model; 2010 Sep; 50(9):1522-8. PubMed ID: 20828111
[TBL] [Abstract][Full Text] [Related]
20. N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bruncko M; Tahir SK; Song X; Chen J; Ding H; Huth JR; Jin S; Judge RA; Madar DJ; Park CH; Park CM; Petros AM; Tse C; Rosenberg SH; Elmore SW
Bioorg Med Chem Lett; 2010 Dec; 20(24):7503-6. PubMed ID: 21106457
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]