BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

131 related articles for article (PubMed ID: 16892354)

  • 1. Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition.
    Minutolo F; Bertini S; Betti L; Danesi R; Gervasi G; Giannaccini G; Martinelli A; Papini AM; Peroni E; Placanica G; Rapposelli S; Tuccinardi T; Macchia M
    ChemMedChem; 2006 Feb; 1(2):218-24. PubMed ID: 16892354
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.
    Minutolo F; Bertini S; Betti L; Danesi R; Gervasi G; Giannaccini G; Papi C; Placanica G; Barontini S; Rapposelli S; Macchia M
    Bioorg Med Chem Lett; 2003 Dec; 13(24):4405-8. PubMed ID: 14643335
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors.
    Minutolo F; Antonello M; Barontini S; Bertini S; Betti L; Danesi R; Gervasi G; Giannaccini G; Papi C; Placanica G; Rapposelli S; Macchia M
    Farmaco; 2004 Nov; 59(11):887-92. PubMed ID: 15544793
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents.
    Minutolo F; Asso V; Bertini S; Betti L; Ciriaco M; Danesi R; Gervasi G; Ghilardi E; Giovanetti E; Giannaccini G; Placanica G; Prota G; Rapposelli S; Macchia M
    Med Chem; 2005 May; 1(3):239-44. PubMed ID: 16787319
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase.
    Minutolo F; Asso V; Bertini S; Betti L; Gervasi G; Ghilardi E; Giannaccini G; Placanica G; Prota G; Rapposelli S; Macchia M
    Farmaco; 2004 Nov; 59(11):857-61. PubMed ID: 15544789
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity.
    Minutolo F; Bertini S; Betti L; Di Bussolo V; Giannaccini G; Placanica G; Rapposelli S; Spielmann HP; Macchia M
    Farmaco; 2003 Dec; 58(12):1277-81. PubMed ID: 14630239
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.
    Dursina B; Reents R; Delon C; Wu Y; Kulharia M; Thutewohl M; Veligodsky A; Kalinin A; Evstifeev V; Ciobanu D; Szedlacsek SE; Waldmann H; Goody RS; Alexandrov K
    J Am Chem Soc; 2006 Mar; 128(9):2822-35. PubMed ID: 16506760
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase.
    Coudray L; de Figueiredo RM; Duez S; Cortial S; Dubois J
    J Enzyme Inhib Med Chem; 2009 Aug; 24(4):972-85. PubMed ID: 19555171
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
    Wiemer AJ; Yu JS; Lamb KM; Hohl RJ; Wiemer DF
    Bioorg Med Chem; 2008 Jan; 16(1):390-9. PubMed ID: 17905588
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I.
    Zahn TJ; Whitney J; Weinbaum C; Gibbs RA
    Bioorg Med Chem Lett; 2001 Jun; 11(12):1605-8. PubMed ID: 11412990
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.
    Temple KJ; Wright EN; Fierke CA; Gibbs RA
    Bioorg Med Chem Lett; 2016 Aug; 26(15):3499-502. PubMed ID: 27342750
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase.
    Turek-Etienne TC; Strickland CL; Distefano MD
    Biochemistry; 2003 Apr; 42(13):3716-24. PubMed ID: 12667062
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological evaluation of lipophilic Ca(1)a(2)L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1.
    El Oualid F; Baktawar J; Leroy IM; van den Elst H; Cohen LH; van der Marel GA; Overkleeft HS; Overhand M
    Bioorg Med Chem; 2005 Mar; 13(5):1463-75. PubMed ID: 15698762
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Coupling of isoprenoid triflates with organoboron nucleophiles: synthesis and biological evaluation of geranylgeranyl diphosphate analogues.
    Mu Y; Eubanks LM; Poulter CD; Gibbs RA
    Bioorg Med Chem; 2002 May; 10(5):1207-19. PubMed ID: 11886785
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue.
    Tong H; Wiemer AJ; Neighbors JD; Hohl RJ
    Anal Biochem; 2008 Jul; 378(2):138-43. PubMed ID: 18457649
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biochemical evaluation of 3,7-disubstituted farnesyl diphosphate analogues.
    Rawat DS; Krzysiak AJ; Gibbs RA
    J Org Chem; 2008 Mar; 73(5):1881-7. PubMed ID: 18225915
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A photoactive isoprenoid diphosphate analogue containing a stable phosphonate linkage: synthesis and biochemical studies with prenyltransferases.
    DeGraw AJ; Zhao Z; Strickland CL; Taban AH; Hsieh J; Jefferies M; Xie W; Shintani DK; McMahan CM; Cornish K; Distefano MD
    J Org Chem; 2007 Jun; 72(13):4587-95. PubMed ID: 17477573
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Studies on geranylgeranyl diphosphate synthase from rat liver: specific inhibition by 3-azageranylgeranyl diphosphate.
    Sagami H; Korenaga T; Ogura K; Steiger A; Pyun HJ; Coates RM
    Arch Biochem Biophys; 1992 Sep; 297(2):314-20. PubMed ID: 1497351
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as farnesyltransferase inhibitors.
    Clark MK; Scott SA; Wojtkowiak J; Chirco R; Mathieu P; Reiners JJ; Mattingly RR; Borch RF; Gibbs RA
    J Med Chem; 2007 Jul; 50(14):3274-82. PubMed ID: 17555307
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.
    Temple KJ; Wright EN; Fierke CA; Gibbs RA
    Bioorg Med Chem Lett; 2016 Aug; 26(15):3503-7. PubMed ID: 27342751
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.