809 related articles for article (PubMed ID: 16904331)
1. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
Chen QH; Rao PN; Knaus EE
Bioorg Med Chem; 2006 Dec; 14(23):7898-909. PubMed ID: 16904331
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN; Chen QH; Knaus EE
J Med Chem; 2006 Mar; 49(5):1668-83. PubMed ID: 16509583
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases.
Moreau A; Chen QH; Praveen Rao PN; Knaus EE
Bioorg Med Chem; 2006 Dec; 14(23):7716-27. PubMed ID: 16931030
[TBL] [Abstract][Full Text] [Related]
4. Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Chowdhury MA; Abdellatif KR; Dong Y; Das D; Suresh MR; Knaus EE
Bioorg Med Chem Lett; 2008 Dec; 18(23):6138-41. PubMed ID: 18945614
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological evaluation of acyclic triaryl (Z)-olefins possessing a 3,5-di-tert-butyl-4-hydroxyphenyl pharmacophore: dual inhibitors of cyclooxygenases and lipoxygenases.
Moreau A; Rao PN; Knaus EE
Bioorg Med Chem; 2006 Aug; 14(15):5340-50. PubMed ID: 16677817
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN; Chen QH; Knaus EE
Bioorg Med Chem Lett; 2005 Nov; 15(21):4842-5. PubMed ID: 16143531
[TBL] [Abstract][Full Text] [Related]
7. Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
Praveen Rao PN; Amini M; Li H; Habeeb AG; Knaus EE
J Med Chem; 2003 Nov; 46(23):4872-82. PubMed ID: 14584938
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors.
Chen QH; Rao PN; Knaus EE
Bioorg Med Chem; 2005 Aug; 13(15):4694-703. PubMed ID: 15914011
[TBL] [Abstract][Full Text] [Related]
9. Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Chowdhury MA; Abdellatif KR; Dong Y; Das D; Suresh MR; Knaus EE
J Med Chem; 2009 Mar; 52(6):1525-9. PubMed ID: 19296694
[TBL] [Abstract][Full Text] [Related]
10. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
Chan CC; Boyce S; Brideau C; Charleson S; Cromlish W; Ethier D; Evans J; Ford-Hutchinson AW; Forrest MJ; Gauthier JY; Gordon R; Gresser M; Guay J; Kargman S; Kennedy B; Leblanc Y; Leger S; Mancini J; O'Neill GP; Ouellet M; Patrick D; Percival MD; Perrier H; Prasit P; Rodger I
J Pharmacol Exp Ther; 1999 Aug; 290(2):551-60. PubMed ID: 10411562
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity.
Zarghi A; Praveen Rao PN; Knaus EE
Bioorg Med Chem; 2007 Jan; 15(2):1056-61. PubMed ID: 17067801
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.
Rao PN; Uddin MJ; Knaus EE
J Med Chem; 2004 Jul; 47(16):3972-90. PubMed ID: 15267236
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: a novel class of cyclooxygenase-2 inhibitors.
Chen QH; Rao PN; Knaus EE
Bioorg Med Chem; 2005 Dec; 13(23):6425-34. PubMed ID: 16099663
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere.
Zarghi A; Rao PN; Knaus EE
J Pharm Pharm Sci; 2007; 10(2):159-67. PubMed ID: 17706175
[TBL] [Abstract][Full Text] [Related]
15. Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor.
Zarghi A; Praveen Rao PN; Knaus EE
Bioorg Med Chem Lett; 2004 Apr; 14(8):1957-60. PubMed ID: 15050636
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.
Yu G; Praveen Rao PN; Chowdhury MA; Abdellatif KR; Dong Y; Das D; Velázquez CA; Suresh MR; Knaus EE
Bioorg Med Chem Lett; 2010 Apr; 20(7):2168-73. PubMed ID: 20202839
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.
Lai Y; Ma L; Huang W; Yu X; Zhang Y; Ji H; Tian J
Bioorg Med Chem Lett; 2010 Dec; 20(24):7349-53. PubMed ID: 21055929
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
Cusan C; Spalluto G; Prato M; Adams M; Bodensieck A; Bauer R; Tubaro A; Bernardi P; Da Ros T
Farmaco; 2005 Apr; 60(4):327-32. PubMed ID: 15848208
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
Cusan C; Spalluto G; Prato M; Adams M; Bodensieck A; Bauer R; Tubaro A; Bernardi P; Da Ros T
Farmaco; 2005 Jan; 60(1):7-13. PubMed ID: 15652362
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.
Chowdhury MA; Dong Y; Chen QH; Abdellatif KR; Knaus EE
Bioorg Med Chem; 2008 Feb; 16(4):1948-56. PubMed ID: 18023187
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]