177 related articles for article (PubMed ID: 16916581)
1. Chinese Presenilin-1 V97L mutation enhanced Abeta42 levels in SH-SY5Y neuroblastoma cells.
Fang B; Jia L; Jia J
Neurosci Lett; 2006 Oct; 406(1-2):33-7. PubMed ID: 16916581
[TBL] [Abstract][Full Text] [Related]
2. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
Esposito L; Gan L; Yu GQ; Essrich C; Mucke L
J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
[TBL] [Abstract][Full Text] [Related]
3. Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.
Takeda K; Araki W; Tabira T
Eur J Neurosci; 2004 Jan; 19(2):258-264. PubMed ID: 14725619
[TBL] [Abstract][Full Text] [Related]
4. Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.
Marambaud P; Ancolio K; Alves da Costa C; Checler F
Br J Pharmacol; 1999 Mar; 126(5):1186-90. PubMed ID: 10205007
[TBL] [Abstract][Full Text] [Related]
5. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
6. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
7. PPAR-α agonist regulates amyloid-β generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe gene.
Zhang H; Gao Y; Qiao PF; Zhao FL; Yan Y
Mol Cell Biochem; 2015 Oct; 408(1-2):37-46. PubMed ID: 26092426
[TBL] [Abstract][Full Text] [Related]
8. Intracellular biology of Alzheimer's disease amyloid beta peptide.
Hartmann T
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):291-8. PubMed ID: 10653285
[TBL] [Abstract][Full Text] [Related]
9. A Novel PSEN1 K311R Mutation Discovered in Chinese Families with Late-Onset Alzheimer's Disease Affects Amyloid-β Production and Tau Phosphorylation.
Dong J; Qin W; Wei C; Tang Y; Wang Q; Jia J
J Alzheimers Dis; 2017; 57(2):613-623. PubMed ID: 28269784
[TBL] [Abstract][Full Text] [Related]
10. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
Siman R; Reaume AG; Savage MJ; Trusko S; Lin YG; Scott RW; Flood DG
J Neurosci; 2000 Dec; 20(23):8717-26. PubMed ID: 11102478
[TBL] [Abstract][Full Text] [Related]
11. APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.
Bergman A; Religa D; Karlström H; Laudon H; Winblad B; Lannfelt L; Lundkvist J; Näslund J
Exp Cell Res; 2003 Jul; 287(1):1-9. PubMed ID: 12799176
[TBL] [Abstract][Full Text] [Related]
12. Mutations in the Amyloid-β Protein Precursor Reduce Mitochondrial Function and Alter Gene Expression Independent of 42-Residue Amyloid-β Peptide.
Pope CA; Wilkins HM; Swerdlow RH; Wolfe MS
J Alzheimers Dis; 2021; 83(3):1039-1049. PubMed ID: 34366346
[TBL] [Abstract][Full Text] [Related]
13. Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.
Ancolio K; Marambaud P; Dauch P; Checler F
J Neurochem; 1997 Dec; 69(6):2494-9. PubMed ID: 9375682
[TBL] [Abstract][Full Text] [Related]
14. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
Qi Y; Morishima-Kawashima M; Sato T; Mitsumori R; Ihara Y
Biochemistry; 2003 Feb; 42(4):1042-52. PubMed ID: 12549925
[TBL] [Abstract][Full Text] [Related]
15. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
16. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; Jenkins NA; Copeland NG; Lee MK; Younkin LH; Wagner SL; Younkin SG; Borchelt DR
Hum Mol Genet; 2004 Jan; 13(2):159-70. PubMed ID: 14645205
[TBL] [Abstract][Full Text] [Related]
17. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
[TBL] [Abstract][Full Text] [Related]
18. Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
Sudoh S; Hua G; Kawamura Y; Maruyama K; Komano H; Yanagisawa K
Eur J Biochem; 2000 Apr; 267(7):2036-45. PubMed ID: 10727943
[TBL] [Abstract][Full Text] [Related]
19. Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology.
Pahrudin Arrozi A; Shukri SNS; Wan Ngah WZ; Mohd Yusof YA; Ahmad Damanhuri MH; Makpol S
Appl Biochem Biotechnol; 2017 Nov; 183(3):853-866. PubMed ID: 28417423
[TBL] [Abstract][Full Text] [Related]
20. A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
Steiner H; Revesz T; Neumann M; Romig H; Grim MG; Pesold B; Kretzschmar HA; Hardy J; Holton JL; Baumeister R; Houlden H; Haass C
J Biol Chem; 2001 Mar; 276(10):7233-9. PubMed ID: 11084029
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]