294 related articles for article (PubMed ID: 16918252)
1. Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.
Alvarez-Sanchez R; Montavon F; Hartung T; Pähler A
Chem Res Toxicol; 2006 Aug; 19(8):1106-16. PubMed ID: 16918252
[TBL] [Abstract][Full Text] [Related]
2. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
Reddy VB; Karanam BV; Gruber WL; Wallace MA; Vincent SH; Franklin RB; Baillie TA
Chem Res Toxicol; 2005 May; 18(5):880-8. PubMed ID: 15892582
[TBL] [Abstract][Full Text] [Related]
3. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Kassahun K; Pearson PG; Tang W; McIntosh I; Leung K; Elmore C; Dean D; Wang R; Doss G; Baillie TA
Chem Res Toxicol; 2001 Jan; 14(1):62-70. PubMed ID: 11170509
[TBL] [Abstract][Full Text] [Related]
4. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
He K; Talaat RE; Pool WF; Reily MD; Reed JE; Bridges AJ; Woolf TF
Drug Metab Dispos; 2004 Jun; 32(6):639-46. PubMed ID: 15155556
[TBL] [Abstract][Full Text] [Related]
5. Metabolic activation of pioglitazone identified from rat and human liver microsomes and freshly isolated hepatocytes.
Baughman TM; Graham RA; Wells-Knecht K; Silver IS; Tyler LO; Wells-Knecht M; Zhao Z
Drug Metab Dispos; 2005 Jun; 33(6):733-8. PubMed ID: 15764718
[TBL] [Abstract][Full Text] [Related]
6. Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.
Madsen KG; Grönberg G; Skonberg C; Jurva U; Hansen SH; Olsen J
Chem Res Toxicol; 2008 Oct; 21(10):2035-41. PubMed ID: 18788755
[TBL] [Abstract][Full Text] [Related]
7. Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.
Saha S; New LS; Ho HK; Chui WK; Chan EC
Toxicol Lett; 2010 Feb; 192(2):141-9. PubMed ID: 19854250
[TBL] [Abstract][Full Text] [Related]
8. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
Yan Z; Easterwood LM; Maher N; Torres R; Huebert N; Yost GS
Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
[TBL] [Abstract][Full Text] [Related]
9. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
Ruan Q; Zhu M
Chem Res Toxicol; 2010 May; 23(5):909-17. PubMed ID: 20297803
[TBL] [Abstract][Full Text] [Related]
10. In vitro investigation of the glutathione transferase M1 and T1 null genotypes as risk factors for troglitazone-induced liver injury.
Usui T; Hashizume T; Katsumata T; Yokoi T; Komuro S
Drug Metab Dispos; 2011 Jul; 39(7):1303-10. PubMed ID: 21511944
[TBL] [Abstract][Full Text] [Related]
11. Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone.
Okada R; Maeda K; Nishiyama T; Aoyama S; Tozuka Z; Hiratsuka A; Ikeda T; Kusuhara H; Sugiyama Y
Drug Metab Dispos; 2011 Dec; 39(12):2290-7. PubMed ID: 21914835
[TBL] [Abstract][Full Text] [Related]
12. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
[TBL] [Abstract][Full Text] [Related]
13. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
[TBL] [Abstract][Full Text] [Related]
14. Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry.
Alvarez-Diez TM; Zheng J
Drug Metab Dispos; 2004 Dec; 32(12):1345-50. PubMed ID: 15328249
[TBL] [Abstract][Full Text] [Related]
15. Production of a reactive metabolite of troglitazone by electrochemical oxidation performed in nonaqueous medium.
Tahara K; Nishikawa T; Hattori Y; Iijima S; Kouno Y; Abe Y
J Pharm Biomed Anal; 2009 Dec; 50(5):1030-6. PubMed ID: 19581066
[TBL] [Abstract][Full Text] [Related]
16. Negative ion tandem mass spectrometry for the detection of glutathione conjugates.
Dieckhaus CM; Fernández-Metzler CL; King R; Krolikowski PH; Baillie TA
Chem Res Toxicol; 2005 Apr; 18(4):630-8. PubMed ID: 15833023
[TBL] [Abstract][Full Text] [Related]
17. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
Wen B; Ma L; Zhu M
Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
[TBL] [Abstract][Full Text] [Related]
18. Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition.
Yan Z; Caldwell GW; Maher N
Anal Chem; 2008 Aug; 80(16):6410-22. PubMed ID: 18642850
[TBL] [Abstract][Full Text] [Related]
19. A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
Lim HK; Chen J; Cook K; Sensenhauser C; Silva J; Evans DC
Rapid Commun Mass Spectrom; 2008 Apr; 22(8):1295-311. PubMed ID: 18383206
[TBL] [Abstract][Full Text] [Related]
20. A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues.
Soglia JR; Contillo LG; Kalgutkar AS; Zhao S; Hop CE; Boyd JG; Cole MJ
Chem Res Toxicol; 2006 Mar; 19(3):480-90. PubMed ID: 16544956
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
