299 related articles for article (PubMed ID: 16923021)
1. Approaches to selective peptidic inhibitors of factor Xa.
Bromfield KM; Quinsey NS; Duggan PJ; Pike RN
Chem Biol Drug Des; 2006 Jul; 68(1):11-9. PubMed ID: 16923021
[TBL] [Abstract][Full Text] [Related]
2. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
Bhunia SS; Roy KK; Saxena AK
J Chem Inf Model; 2011 Aug; 51(8):1966-85. PubMed ID: 21761917
[TBL] [Abstract][Full Text] [Related]
3. Kinetics of factor Xa inhibition by recombinant tick anticoagulant peptide: both active site and exosite interactions are required for a slow- and tight-binding inhibition mechanism.
Rezaie AR
Biochemistry; 2004 Mar; 43(12):3368-75. PubMed ID: 15035608
[TBL] [Abstract][Full Text] [Related]
4. Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors.
Maduskuie TP; McNamara KJ; Ru Y; Knabb RM; Stouten PF
J Med Chem; 1998 Jan; 41(1):53-62. PubMed ID: 9438022
[TBL] [Abstract][Full Text] [Related]
5. Comparative binding energy analysis considering multiple receptors: a step toward 3D-QSAR models for multiple targets.
Murcia M; Morreale A; Ortiz AR
J Med Chem; 2006 Oct; 49(21):6241-53. PubMed ID: 17034130
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
Lin J; Deng H; Jin L; Pandey P; Quinn J; Cantin S; Rynkiewicz MJ; Gorga JC; Bibbins F; Celatka CA; Nagafuji P; Bannister TD; Meyers HV; Babine RE; Hayward NJ; Weaver D; Benjamin H; Stassen F; Abdel-Meguid SS; Strickler JE
J Med Chem; 2006 Dec; 49(26):7781-91. PubMed ID: 17181160
[TBL] [Abstract][Full Text] [Related]
7. Active and exo-site inhibition of human factor Xa: structure of des-Gla factor Xa inhibited by NAP5, a potent nematode anticoagulant protein from Ancylostoma caninum.
Rios-Steiner JL; Murakami MT; Tulinsky A; Arni RK
J Mol Biol; 2007 Aug; 371(3):774-86. PubMed ID: 17588602
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa.
Willardsen JA; Dudley DA; Cody WL; Chi L; McClanahan TB; Mertz TE; Potoczak RE; Narasimhan LS; Holland DR; Rapundalo ST; Edmunds JJ
J Med Chem; 2004 Jul; 47(16):4089-99. PubMed ID: 15267248
[TBL] [Abstract][Full Text] [Related]
9. Tetrahydro-isoquinoline-based factor Xa inhibitors.
Kucznierz R; Grams F; Leinert H; Marzenell K; Engh RA; von der Saal W
J Med Chem; 1998 Dec; 41(25):4983-94. PubMed ID: 9836616
[TBL] [Abstract][Full Text] [Related]
10. Discovery of a novel, potent, and specific family of factor Xa inhibitors via combinatorial chemistry.
Ostrem JA; al-Obeidi F; Safar P; Safarova A; Stringer SK; Patek M; Cross MT; Spoonamore J; LoCascio JC; Kasireddy P; Thorpe DS; Sepetov N; Lebl M; Wildgoose P; Strop P
Biochemistry; 1998 Jan; 37(4):1053-9. PubMed ID: 9454596
[TBL] [Abstract][Full Text] [Related]
11. Synthetic peptides and peptidomimetics as substrates and inhibitors of thrombin and other proteases in the blood coagulation system.
Claeson G
Blood Coagul Fibrinolysis; 1994 Jun; 5(3):411-36. PubMed ID: 8075312
[TBL] [Abstract][Full Text] [Related]
12. Secondary structure peptide mimetics: design, synthesis, and evaluation of beta-strand mimetic thrombin inhibitors.
Boatman PD; Ogbu CO; Eguchi M; Kim HO; Nakanishi H; Cao B; Shea JP; Kahn M
J Med Chem; 1999 Apr; 42(8):1367-75. PubMed ID: 10212122
[TBL] [Abstract][Full Text] [Related]
13. Highly potent and selective substrate analogue factor Xa inhibitors containing D-homophenylalanine analogues as P3 residue: part 2.
Stürzebecher A; Dönnecke D; Schweinitz A; Schuster O; Steinmetzer P; Stürzebecher U; Kotthaus J; Clement B; Stürzebecher J; Steinmetzer T
ChemMedChem; 2007 Jul; 2(7):1043-53. PubMed ID: 17541992
[TBL] [Abstract][Full Text] [Related]
14. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
[TBL] [Abstract][Full Text] [Related]
15. The extended interactions and Gla domain of blood coagulation factor Xa.
Wang SX; Hur E; Sousa CA; Brinen L; Slivka EJ; Fletterick RJ
Biochemistry; 2003 Jul; 42(26):7959-66. PubMed ID: 12834348
[TBL] [Abstract][Full Text] [Related]
16. NMR structure determination of tick anticoagulant peptide (TAP).
Lim-Wilby MS; Hallenga K; de Maeyer M; Lasters I; Vlasuk GP; Brunck TK
Protein Sci; 1995 Feb; 4(2):178-86. PubMed ID: 7538849
[TBL] [Abstract][Full Text] [Related]
17. Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library.
Sagi K; Fujita K; Sugiki M; Takahashi M; Takehana S; Tashiro K; Kayahara T; Yamanashi M; Fukuda Y; Oono S; Okajima A; Iwata S; Shoji M; Sakurai K
Bioorg Med Chem; 2005 Mar; 13(5):1487-96. PubMed ID: 15698764
[TBL] [Abstract][Full Text] [Related]
18. The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
Friedrich R; Steinmetzer T; Huber R; Stürzebecher J; Bode W
J Mol Biol; 2002 Mar; 316(4):869-74. PubMed ID: 11884127
[TBL] [Abstract][Full Text] [Related]
19. Interaction of antistasin-related peptides with factor Xa: identification of a core inhibitory sequence.
Ohta N; Brush M; Jacobs JW
Thromb Haemost; 1994 Dec; 72(6):825-30. PubMed ID: 7740449
[TBL] [Abstract][Full Text] [Related]
20. A new factor Xa inhibitor (lefaxin) from the Haementeria depressa leech.
Faria F; Kelen EM; Sampaio CA; Bon C; Duval N; Chudzinski-Tavassi AM
Thromb Haemost; 1999 Nov; 82(5):1469-73. PubMed ID: 10595640
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]