These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

120 related articles for article (PubMed ID: 16928049)

  • 1. A highly efficient synthesis of potent and selective butyrolactam inhibitors of 11beta-HSD1.
    Yeh VS; Kurukulasuriya R; Kerdesky FA
    Org Lett; 2006 Aug; 8(18):3963-6. PubMed ID: 16928049
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.
    Yeh VS; Kurukulasuriya R; Fung S; Monzon K; Chiou W; Wang J; Stolarik D; Imade H; Shapiro R; Knourek-Segel V; Bush E; Wilcox D; Nguyen PT; Brune M; Jacobson P; Link JT
    Bioorg Med Chem Lett; 2006 Nov; 16(21):5555-60. PubMed ID: 16931002
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Xiang J; Ipek M; Suri V; Massefski W; Pan N; Ge Y; Tam M; Xing Y; Tobin JF; Xu X; Tam S
    Bioorg Med Chem Lett; 2005 Jun; 15(11):2865-9. PubMed ID: 15911270
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
    Sun D; Wang Z; Di Y; Jaen JC; Labelle M; Ma J; Miao S; Sudom A; Tang L; Tomooka CS; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3513-6. PubMed ID: 18511278
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.
    Xiang J; Wan ZK; Li HQ; Ipek M; Binnun E; Nunez J; Chen L; McKew JC; Mansour TS; Xu X; Suri V; Tam M; Xing Y; Li X; Hahm S; Tobin J; Saiah E
    J Med Chem; 2008 Jul; 51(14):4068-71. PubMed ID: 18578516
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.
    Julian LD; Wang Z; Bostick T; Caille S; Choi R; DeGraffenreid M; Di Y; He X; Hungate RW; Jaen JC; Liu J; Monshouwer M; McMinn D; Rew Y; Sudom A; Sun D; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
    J Med Chem; 2008 Jul; 51(13):3953-60. PubMed ID: 18553955
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
    Johansson L; Fotsch C; Bartberger MD; Castro VM; Chen M; Emery M; Gustafsson S; Hale C; Hickman D; Homan E; Jordan SR; Komorowski R; Li A; McRae K; Moniz G; Matsumoto G; Orihuela C; Palm G; Veniant M; Wang M; Williams M; Zhang J
    J Med Chem; 2008 May; 51(10):2933-43. PubMed ID: 18419108
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Substituted phenyl triazoles as selective inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1.
    Sun W; Maletic M; Mundt SS; Shah K; Zokian H; Lyons K; Waddell ST; Balkovec J
    Bioorg Med Chem Lett; 2011 Apr; 21(7):2141-5. PubMed ID: 21334894
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
    Tu H; Powers JP; Liu J; Ursu S; Sudom A; Yan X; Xu H; Meininger D; Degraffenreid M; He X; Jaen JC; Sun D; Labelle M; Yamamoto H; Shan B; Walker NP; Wang Z
    Bioorg Med Chem; 2008 Oct; 16(19):8922-31. PubMed ID: 18789704
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Roche D; Carniato D; Leriche C; Lepifre F; Christmann-Franck S; Graedler U; Charon C; Bozec S; Doare L; Schmidlin F; Lecomte M; Valeur E
    Bioorg Med Chem Lett; 2009 May; 19(10):2674-8. PubMed ID: 19395260
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.
    Yang H; Dou W; Lou J; Leng Y; Shen J
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1340-5. PubMed ID: 18242087
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.
    Webster SP; Ward P; Binnie M; Craigie E; McConnell KM; Sooy K; Vinter A; Seckl JR; Walker BR
    Bioorg Med Chem Lett; 2007 May; 17(10):2838-43. PubMed ID: 17350260
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.
    Gu X; Dragovic J; Koo GC; Koprak SL; LeGrand C; Mundt SS; Shah K; Springer MS; Tan EY; Thieringer R; Hermanowski-Vosatka A; Zokian HJ; Balkovec JM; Waddell ST
    Bioorg Med Chem Lett; 2005 Dec; 15(23):5266-9. PubMed ID: 16185866
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 11beta-Hydroxysteroid dehydrogenase type 1 inhibitors with oleanan and ursan scaffolds.
    Blum A; Favia AD; Maser E
    Mol Cell Endocrinol; 2009 Mar; 301(1-2):132-6. PubMed ID: 18822345
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
    Su X; Vicker N; Ganeshapillai D; Smith A; Purohit A; Reed MJ; Potter BV
    Mol Cell Endocrinol; 2006 Mar; 248(1-2):214-7. PubMed ID: 16325333
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
    Su X; Vicker N; Trusselle M; Halem H; Culler MD; Potter BV
    Mol Cell Endocrinol; 2009 Mar; 301(1-2):169-73. PubMed ID: 18775471
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Zhu Y; Olson SH; Hermanowski-Vosatka A; Mundt S; Shah K; Springer M; Thieringer R; Wright S; Xiao J; Zokian H; Balkovec JM
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3405-11. PubMed ID: 18440811
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.
    Zhang X; Zhou Z; Yang H; Chen J; Feng Y; Du L; Leng Y; Shen J
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4455-8. PubMed ID: 19564108
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.
    Yan X; Wang Z; Sudom A; Cardozo M; DeGraffenreid M; Di Y; Fan P; He X; Jaen JC; Labelle M; Liu J; Ma J; McMinn D; Miao S; Sun D; Tang L; Tu H; Ursu S; Walker N; Ye Q; Powers JP
    Bioorg Med Chem Lett; 2010 Dec; 20(23):7071-5. PubMed ID: 20971000
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
    Wang H; Ruan Z; Li JJ; Simpkins LM; Smirk RA; Wu SC; Hutchins RD; Nirschl DS; Van Kirk K; Cooper CB; Sutton JC; Ma Z; Golla R; Seethala R; Salyan ME; Nayeem A; Krystek SR; Sheriff S; Camac DM; Morin PE; Carpenter B; Robl JA; Zahler R; Gordon DA; Hamann LG
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3168-72. PubMed ID: 18485702
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.