These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

220 related articles for article (PubMed ID: 16936775)

  • 1. The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase.
    Oliva-Trastoy M; Berthonaud V; Chevalier A; Ducrot C; Marsolier-Kergoat MC; Mann C; Leteurtre F
    Oncogene; 2007 Mar; 26(10):1449-58. PubMed ID: 16936775
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.
    Fujimoto H; Onishi N; Kato N; Takekawa M; Xu XZ; Kosugi A; Kondo T; Imamura M; Oishi I; Yoda A; Minami Y
    Cell Death Differ; 2006 Jul; 13(7):1170-80. PubMed ID: 16311512
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase.
    Yoda A; Toyoshima K; Watanabe Y; Onishi N; Hazaka Y; Tsukuda Y; Tsukada J; Kondo T; Tanaka Y; Minami Y
    J Biol Chem; 2008 Jul; 283(27):18969-79. PubMed ID: 18482988
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.
    Carlessi L; Buscemi G; Fontanella E; Delia D
    Biochim Biophys Acta; 2010 Oct; 1803(10):1213-23. PubMed ID: 20599567
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Increased wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) expression correlated with downregulation of checkpoint kinase 2 in human gastric carcinoma.
    Fuku T; Semba S; Yutori H; Yokozaki H
    Pathol Int; 2007 Sep; 57(9):566-71. PubMed ID: 17685927
    [TBL] [Abstract][Full Text] [Related]  

  • 6. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.
    Lu X; Nannenga B; Donehower LA
    Genes Dev; 2005 May; 19(10):1162-74. PubMed ID: 15870257
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Wip1 phosphatase modulates ATM-dependent signaling pathways.
    Shreeram S; Demidov ON; Hee WK; Yamaguchi H; Onishi N; Kek C; Timofeev ON; Dudgeon C; Fornace AJ; Anderson CW; Minami Y; Appella E; Bulavin DV
    Mol Cell; 2006 Sep; 23(5):757-64. PubMed ID: 16949371
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
    Bahassi el M; Myer DL; McKenney RJ; Hennigan RF; Stambrook PJ
    Mutat Res; 2006 Apr; 596(1-2):166-76. PubMed ID: 16481012
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases.
    Yamaguchi H; Durell SR; Chatterjee DK; Anderson CW; Appella E
    Biochemistry; 2007 Nov; 46(44):12594-603. PubMed ID: 17939684
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.
    Chaturvedi P; Eng WK; Zhu Y; Mattern MR; Mishra R; Hurle MR; Zhang X; Annan RS; Lu Q; Faucette LF; Scott GF; Li X; Carr SA; Johnson RK; Winkler JD; Zhou BB
    Oncogene; 1999 Jul; 18(28):4047-54. PubMed ID: 10435585
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
    Matsuoka S; Rotman G; Ogawa A; Shiloh Y; Tamai K; Elledge SJ
    Proc Natl Acad Sci U S A; 2000 Sep; 97(19):10389-94. PubMed ID: 10973490
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.
    Yoda A; Xu XZ; Onishi N; Toyoshima K; Fujimoto H; Kato N; Oishi I; Kondo T; Minami Y
    J Biol Chem; 2006 Aug; 281(34):24847-62. PubMed ID: 16798742
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.
    Ahn JY; Schwarz JK; Piwnica-Worms H; Canman CE
    Cancer Res; 2000 Nov; 60(21):5934-6. PubMed ID: 11085506
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
    Falck J; Mailand N; Syljuåsen RG; Bartek J; Lukas J
    Nature; 2001 Apr; 410(6830):842-7. PubMed ID: 11298456
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.
    Zhou BB; Chaturvedi P; Spring K; Scott SP; Johanson RA; Mishra R; Mattern MR; Winkler JD; Khanna KK
    J Biol Chem; 2000 Apr; 275(14):10342-8. PubMed ID: 10744722
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.
    Lu X; Nguyen TA; Donehower LA
    Cell Cycle; 2005 Aug; 4(8):1060-4. PubMed ID: 15970689
    [TBL] [Abstract][Full Text] [Related]  

  • 17. STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage.
    Townsend PA; Cragg MS; Davidson SM; McCormick J; Barry S; Lawrence KM; Knight RA; Hubank M; Chen PL; Latchman DS; Stephanou A
    J Cell Sci; 2005 Apr; 118(Pt 8):1629-39. PubMed ID: 15784679
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
    Nannenga B; Lu X; Dumble M; Van Maanen M; Nguyen TA; Sutton R; Kumar TR; Donehower LA
    Mol Carcinog; 2006 Aug; 45(8):594-604. PubMed ID: 16652371
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.
    Oliver AW; Paul A; Boxall KJ; Barrie SE; Aherne GW; Garrett MD; Mittnacht S; Pearl LH
    EMBO J; 2006 Jul; 25(13):3179-90. PubMed ID: 16794575
    [TBL] [Abstract][Full Text] [Related]  

  • 20. ATR dependent activation of Chk2.
    Wang XQ; Redpath JL; Fan ST; Stanbridge EJ
    J Cell Physiol; 2006 Sep; 208(3):613-9. PubMed ID: 16741947
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.