BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

109 related articles for article (PubMed ID: 16940414)

  • 1. Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.
    Pei XY; Li W; Dai Y; Dent P; Grant S
    Mol Pharmacol; 2006 Dec; 70(6):1965-73. PubMed ID: 16940414
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.
    Dai Y; Landowski TH; Rosen ST; Dent P; Grant S
    Blood; 2002 Nov; 100(9):3333-43. PubMed ID: 12384435
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
    Dai Y; Rahmani M; Pei XY; Khanna P; Han SI; Mitchell C; Dent P; Grant S
    Blood; 2005 Feb; 105(4):1706-16. PubMed ID: 15494423
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
    Hahn M; Li W; Yu C; Rahmani M; Dent P; Grant S
    Mol Cancer Ther; 2005 Mar; 4(3):457-70. PubMed ID: 15767555
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.
    Pei XY; Dai Y; Tenorio S; Lu J; Harada H; Dent P; Grant S
    Blood; 2007 Sep; 110(6):2092-101. PubMed ID: 17540843
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo.
    Dai Y; Chen S; Shah R; Pei XY; Wang L; Almenara JA; Kramer LB; Dent P; Grant S
    Blood; 2011 Feb; 117(6):1947-57. PubMed ID: 21148814
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.
    Dai Y; Pei XY; Rahmani M; Conrad DH; Dent P; Grant S
    Blood; 2004 Apr; 103(7):2761-70. PubMed ID: 14645003
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.
    Pei XY; Dai Y; Rahmani M; Li W; Dent P; Grant S
    Clin Cancer Res; 2005 Jun; 11(12):4589-600. PubMed ID: 15958645
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
    Dai Y; Yu C; Singh V; Tang L; Wang Z; McInistry R; Dent P; Grant S
    Cancer Res; 2001 Jul; 61(13):5106-15. PubMed ID: 11431348
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.
    Dai Y; Chen S; Pei XY; Almenara JA; Kramer LB; Venditti CA; Dent P; Grant S
    Blood; 2008 Sep; 112(6):2439-49. PubMed ID: 18614762
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
    Yu C; Krystal G; Varticovksi L; McKinstry R; Rahmani M; Dent P; Grant S
    Cancer Res; 2002 Jan; 62(1):188-99. PubMed ID: 11782377
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.
    Dai Y; Dent P; Grant S
    Mol Pharmacol; 2003 Dec; 64(6):1402-9. PubMed ID: 14645670
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Enhancing CHK1 inhibitor lethality in glioblastoma.
    Tang Y; Dai Y; Grant S; Dent P
    Cancer Biol Ther; 2012 Apr; 13(6):379-88. PubMed ID: 22313687
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.
    Jia W; Yu C; Rahmani M; Krystal G; Sausville EA; Dent P; Grant S
    Blood; 2003 Sep; 102(5):1824-32. PubMed ID: 12738674
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation.
    Wei F; Xie Y; He L; Tao L; Tang D
    Cell Signal; 2011 Jan; 23(1):259-68. PubMed ID: 20840867
    [TBL] [Abstract][Full Text] [Related]  

  • 16. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
    Yu Q; La Rose J; Zhang H; Takemura H; Kohn KW; Pommier Y
    Cancer Res; 2002 Oct; 62(20):5743-8. PubMed ID: 12384533
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
    Shao RG; Cao CX; Pommier Y
    Acta Pharmacol Sin; 2004 Jun; 25(6):756-62. PubMed ID: 15169628
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
    Dai Y; Khanna P; Chen S; Pei XY; Dent P; Grant S
    Blood; 2007 May; 109(10):4415-23. PubMed ID: 17264303
    [TBL] [Abstract][Full Text] [Related]  

  • 19. BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.
    Yan Y; Spieker RS; Kim M; Stoeger SM; Cowan KH
    Oncogene; 2005 May; 24(20):3285-96. PubMed ID: 15735702
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.
    Mitchell C; Park M; Eulitt P; Yang C; Yacoub A; Dent P
    Mol Pharmacol; 2010 Nov; 78(5):909-17. PubMed ID: 20696794
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.