BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

197 related articles for article (PubMed ID: 16943199)

  • 1. Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
    Johnson AA; Sayer JM; Yagi H; Patil SS; Debart F; Maier MA; Corey DR; Vasseur JJ; Burke TR; Marquez VE; Jerina DM; Pommier Y
    J Biol Chem; 2006 Oct; 281(43):32428-38. PubMed ID: 16943199
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Position-specific suppression and enhancement of HIV-1 integrase reactions by minor groove benzo[a]pyrene diol epoxide deoxyguanine adducts: implications for molecular interactions between integrase and substrates.
    Johnson AA; Sayer JM; Yagi H; Kalena GP; Amin R; Jerina DM; Pommier Y
    J Biol Chem; 2004 Feb; 279(9):7947-55. PubMed ID: 14627697
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dissecting Tn5 transposition using HIV-1 integrase diketoacid inhibitors.
    Czyz A; Stillmock KA; Hazuda DJ; Reznikoff WS
    Biochemistry; 2007 Sep; 46(38):10776-89. PubMed ID: 17725323
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A.
    Choudhary S; Doherty KM; Handy CJ; Sayer JM; Yagi H; Jerina DM; Brosh RM
    J Biol Chem; 2006 Mar; 281(9):6000-9. PubMed ID: 16380375
    [TBL] [Abstract][Full Text] [Related]  

  • 5. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase.
    Espeseth AS; Felock P; Wolfe A; Witmer M; Grobler J; Anthony N; Egbertson M; Melamed JY; Young S; Hamill T; Cole JL; Hazuda DJ
    Proc Natl Acad Sci U S A; 2000 Oct; 97(21):11244-9. PubMed ID: 11016953
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate.
    Savarino A
    Retrovirology; 2007 Mar; 4():21. PubMed ID: 17374162
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Probing HIV-1 integrase inhibitor binding sites with position-specific integrase-DNA cross-linking assays.
    Johnson AA; Marchand C; Patil SS; Costi R; Di Santo R; Burke TR; Pommier Y
    Mol Pharmacol; 2007 Mar; 71(3):893-901. PubMed ID: 17172465
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotides.
    Brodin P; Pinskaya M; Buckle M; Parsch U; Romanova E; Engels J; Gottikh M; Mouscadet JF
    Biochemistry; 2002 Feb; 41(5):1529-38. PubMed ID: 11814346
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-activity relationships of HIV-1 integrase inhibitors--enzyme-ligand interactions.
    Maurin C; Bailly F; Cotelle P
    Curr Med Chem; 2003 Sep; 10(18):1795-810. PubMed ID: 12871105
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.
    Métifiot M; Johnson BC; Kiselev E; Marler L; Zhao XZ; Burke TR; Marchand C; Hughes SH; Pommier Y
    Nucleic Acids Res; 2016 Aug; 44(14):6896-906. PubMed ID: 27369381
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.
    Dicker IB; Samanta HK; Li Z; Hong Y; Tian Y; Banville J; Remillard RR; Walker MA; Langley DR; Krystal M
    J Biol Chem; 2007 Oct; 282(43):31186-96. PubMed ID: 17715137
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.
    Kehlenbeck S; Betz U; Birkmann A; Fast B; Göller AH; Henninger K; Lowinger T; Marrero D; Paessens A; Paulsen D; Pevzner V; Schohe-Loop R; Tsujishita H; Welker R; Kreuter J; Rübsamen-Waigmann H; Dittmer F
    J Virol; 2006 Jul; 80(14):6883-94. PubMed ID: 16809294
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Probing of HIV-1 integrase/DNA interactions using novel analogs of viral DNA.
    Agapkina J; Smolov M; Barbe S; Zubin E; Zatsepin T; Deprez E; Le Bret M; Mouscadet JF; Gottikh M
    J Biol Chem; 2006 Apr; 281(17):11530-40. PubMed ID: 16500899
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.
    Hazuda DJ; Felock P; Witmer M; Wolfe A; Stillmock K; Grobler JA; Espeseth A; Gabryelski L; Schleif W; Blau C; Miller MD
    Science; 2000 Jan; 287(5453):646-50. PubMed ID: 10649997
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Substrate features important for recognition and catalysis by human immunodeficiency virus type 1 integrase identified by using novel DNA substrates.
    Chow SA; Brown PO
    J Virol; 1994 Jun; 68(6):3896-907. PubMed ID: 8189526
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro assays for activities of retroviral integrase.
    Chow SA
    Methods; 1997 Aug; 12(4):306-17. PubMed ID: 9245611
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.
    Chen X; Tsiang M; Yu F; Hung M; Jones GS; Zeynalzadegan A; Qi X; Jin H; Kim CU; Swaminathan S; Chen JM
    J Mol Biol; 2008 Jul; 380(3):504-19. PubMed ID: 18565342
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.
    Molteni V; Greenwald J; Rhodes D; Hwang Y; Kwiatkowski W; Bushman FD; Siegel JS; Choe S
    Acta Crystallogr D Biol Crystallogr; 2001 Apr; 57(Pt 4):536-44. PubMed ID: 11264582
    [TBL] [Abstract][Full Text] [Related]  

  • 19. [Interactions of HIV-1 DNA heterocyclic bases with viral DNA].
    Agapkina IuIu; Tashlitskiĭ VN; Deprez E; Brochon JC; Shugaliĭ AV; Mouscadet JF; Gottikh MB
    Mol Biol (Mosk); 2004; 38(5):848-57. PubMed ID: 15554187
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.
    Cherepanov P; Esté JA; Rando RF; Ojwang JO; Reekmans G; Steinfeld R; David G; De Clercq E; Debyser Z
    Mol Pharmacol; 1997 Nov; 52(5):771-80. PubMed ID: 9351967
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.