These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

213 related articles for article (PubMed ID: 16956297)

  • 21. Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target.
    Srivastava A; Mukherjee P; Desai PV; Avery MA; Tekwani BL
    Infect Disord Drug Targets; 2008 Mar; 8(1):16-30. PubMed ID: 18473904
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Crystal structures of human IPP isomerase: new insights into the catalytic mechanism.
    Zhang C; Liu L; Xu H; Wei Z; Wang Y; Lin Y; Gong W
    J Mol Biol; 2007 Mar; 366(5):1437-46. PubMed ID: 17137593
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis.
    Martin MB; Arnold W; Heath HT; Urbina JA; Oldfield E
    Biochem Biophys Res Commun; 1999 Oct; 263(3):754-8. PubMed ID: 10512752
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
    Park J; Lin YS; De Schutter JW; Tsantrizos YS; Berghuis AM
    BMC Struct Biol; 2012 Dec; 12():32. PubMed ID: 23234314
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
    Tsoumpra MK; Muniz JR; Barnett BL; Kwaasi AA; Pilka ES; Kavanagh KL; Evdokimov A; Walter RL; Von Delft F; Ebetino FH; Oppermann U; Russell RGG; Dunford JE
    Bone; 2015 Dec; 81():478-486. PubMed ID: 26318908
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
    Mao J; Mukherjee S; Zhang Y; Cao R; Sanders JM; Song Y; Zhang Y; Meints GA; Gao YG; Mukkamala D; Hudock MP; Oldfield E
    J Am Chem Soc; 2006 Nov; 128(45):14485-97. PubMed ID: 17090032
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Bisphosphonates: from bench to bedside.
    Russell RG
    Ann N Y Acad Sci; 2006 Apr; 1068():367-401. PubMed ID: 16831938
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Farnesyl diphosphate synthase assay.
    Arró M; Manzano D; Ferrer A
    Methods Mol Biol; 2014; 1153():41-53. PubMed ID: 24777789
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase.
    Saito K; Fujisaki S; Nishino T
    J Biosci Bioeng; 2007 Jun; 103(6):575-7. PubMed ID: 17630132
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Escherichia coli type I isopentenyl diphosphate isomerase: structural and catalytic roles for divalent metals.
    Lee S; Poulter CD
    J Am Chem Soc; 2006 Sep; 128(35):11545-50. PubMed ID: 16939278
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.
    Aripirala S; Gonzalez-Pacanowska D; Oldfield E; Kaiser M; Amzel LM; Gabelli SB
    Acta Crystallogr D Biol Crystallogr; 2014 Mar; 70(Pt 3):802-10. PubMed ID: 24598749
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
    Dunford JE; Kwaasi AA; Rogers MJ; Barnett BL; Ebetino FH; Russell RG; Oppermann U; Kavanagh KL
    J Med Chem; 2008 Apr; 51(7):2187-95. PubMed ID: 18327899
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions.
    Cane DE; Abell C; Harrison PH; Hubbard BR; Kane CT; Lattman R; Oliver JS; Weiner SW
    Philos Trans R Soc Lond B Biol Sci; 1991 May; 332(1263):123-9. PubMed ID: 1678531
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay.
    Glickman JF; Schmid A
    Assay Drug Dev Technol; 2007 Apr; 5(2):205-14. PubMed ID: 17477829
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Bisphosphonates: mode of action and pharmacology.
    Russell RG
    Pediatrics; 2007 Mar; 119 Suppl 2():S150-62. PubMed ID: 17332236
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase.
    Yokoyama T; Mizuguchi M; Ostermann A; Kusaka K; Niimura N; Schrader TE; Tanaka I
    J Med Chem; 2015 Sep; 58(18):7549-56. PubMed ID: 26314394
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Purification, properties and heteromeric association of type-1 and type-2 lepidopteran farnesyl diphosphate synthases.
    Sen SE; Cusson M; Trobaugh C; Béliveau C; Richard T; Graham W; Mimms A; Roberts G
    Insect Biochem Mol Biol; 2007 Aug; 37(8):819-28. PubMed ID: 17628280
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Fragment-Based Discovery of Non-bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase.
    Münzker L; Petrick JK; Schleberger C; Clavel D; Cornaciu I; Wilcken R; Márquez JA; Klebe G; Marzinzik A; Jahnke W
    Chembiochem; 2020 Nov; 21(21):3096-3111. PubMed ID: 32537808
    [TBL] [Abstract][Full Text] [Related]  

  • 39. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
    Kavanagh KL; Guo K; Dunford JE; Wu X; Knapp S; Ebetino FH; Rogers MJ; Russell RG; Oppermann U
    Proc Natl Acad Sci U S A; 2006 May; 103(20):7829-34. PubMed ID: 16684881
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Reaction kinetics, catalytic mechanisms, conformational changes, and inhibitor design for prenyltransferases.
    Liang PH
    Biochemistry; 2009 Jul; 48(28):6562-70. PubMed ID: 19537817
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.