505 related articles for article (PubMed ID: 16958988)
1. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.
Lea PM; Faden AI
CNS Drug Rev; 2006; 12(2):149-66. PubMed ID: 16958988
[TBL] [Abstract][Full Text] [Related]
2. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles.
Varty GB; Grilli M; Forlani A; Fredduzzi S; Grzelak ME; Guthrie DH; Hodgson RA; Lu SX; Nicolussi E; Pond AJ; Parker EM; Hunter JC; Higgins GA; Reggiani A; Bertorelli R
Psychopharmacology (Berl); 2005 Apr; 179(1):207-17. PubMed ID: 15682298
[TBL] [Abstract][Full Text] [Related]
3. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
Lea PM; Movsesyan VA; Faden AI
Br J Pharmacol; 2005 Jun; 145(4):527-34. PubMed ID: 15821750
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.
Iso Y; Grajkowska E; Wroblewski JT; Davis J; Goeders NE; Johnson KM; Sanker S; Roth BL; Tueckmantel W; Kozikowski AP
J Med Chem; 2006 Feb; 49(3):1080-100. PubMed ID: 16451073
[TBL] [Abstract][Full Text] [Related]
5. mGluR5 antagonist-induced psychoactive properties: MTEP drug discrimination, a pharmacologically selective non-NMDA effect with apparent lack of reinforcing properties.
Swedberg MD; Ellgren M; Raboisson P
J Pharmacol Exp Ther; 2014 Apr; 349(1):155-64. PubMed ID: 24472725
[TBL] [Abstract][Full Text] [Related]
6. Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP.
Gass JT; Olive MF
Eur J Pharmacol; 2008 Apr; 584(2-3):253-62. PubMed ID: 18346726
[TBL] [Abstract][Full Text] [Related]
7. [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.
Anderson JJ; Rao SP; Rowe B; Giracello DR; Holtz G; Chapman DF; Tehrani L; Bradbury MJ; Cosford ND; Varney MA
J Pharmacol Exp Ther; 2002 Dec; 303(3):1044-51. PubMed ID: 12438526
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of human hepatic CYP isoforms by mGluR5 antagonists.
Green MD; Jiang X; King CD
Life Sci; 2004 Jul; 75(8):947-53. PubMed ID: 15193955
[TBL] [Abstract][Full Text] [Related]
9. Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.
Kulkarni SS; Zou MF; Cao J; Deschamps JR; Rodriguez AL; Conn PJ; Newman AH
J Med Chem; 2009 Jun; 52(11):3563-75. PubMed ID: 19445453
[TBL] [Abstract][Full Text] [Related]
10. Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities.
Zhu CZ; Wilson SG; Mikusa JP; Wismer CT; Gauvin DM; Lynch JJ; Wade CL; Decker MW; Honore P
Eur J Pharmacol; 2004 Dec; 506(2):107-18. PubMed ID: 15588730
[TBL] [Abstract][Full Text] [Related]
11. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats.
Keck TM; Zou MF; Bi GH; Zhang HY; Wang XF; Yang HJ; Srivastava R; Gardner EL; Xi ZX; Newman AH
Addict Biol; 2014 Mar; 19(2):195-209. PubMed ID: 24001208
[TBL] [Abstract][Full Text] [Related]
12. AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects.
Swedberg MD; Raboisson P
J Pharmacol Exp Ther; 2014 Aug; 350(2):212-22. PubMed ID: 24876235
[TBL] [Abstract][Full Text] [Related]
13. Reduced stress-induced hyperthermia in mGluR5 knockout mice.
Brodkin J; Bradbury M; Busse C; Warren N; Bristow LJ; Varney MA
Eur J Neurosci; 2002 Dec; 16(11):2241-4. PubMed ID: 12473093
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5.
Wang JQ; Tueckmantel W; Zhu A; Pellegrino D; Brownell AL
Synapse; 2007 Dec; 61(12):951-61. PubMed ID: 17787003
[TBL] [Abstract][Full Text] [Related]
15. Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests.
Belozertseva IV; Kos T; Popik P; Danysz W; Bespalov AY
Eur Neuropsychopharmacol; 2007 Feb; 17(3):172-9. PubMed ID: 16630709
[TBL] [Abstract][Full Text] [Related]
16. The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats.
Rasmussen K; Martin H; Berger JE; Seager MA
Neuropharmacology; 2005 Feb; 48(2):173-80. PubMed ID: 15695156
[TBL] [Abstract][Full Text] [Related]
17. mGluR5, but not mGluR1, antagonist modifies MK-801-induced locomotor activity and deficit of prepulse inhibition.
Pietraszek M; Gravius A; Schäfer D; Weil T; Trifanova D; Danysz W
Neuropharmacology; 2005 Jul; 49(1):73-85. PubMed ID: 15992582
[TBL] [Abstract][Full Text] [Related]
18. Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine.
Lee B; Platt DM; Rowlett JK; Adewale AS; Spealman RD
J Pharmacol Exp Ther; 2005 Mar; 312(3):1232-40. PubMed ID: 15550570
[TBL] [Abstract][Full Text] [Related]
19. The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.
Busse CS; Brodkin J; Tattersall D; Anderson JJ; Warren N; Tehrani L; Bristow LJ; Varney MA; Cosford ND
Neuropsychopharmacology; 2004 Nov; 29(11):1971-9. PubMed ID: 15305166
[TBL] [Abstract][Full Text] [Related]
20. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
O'Leary DM; Movsesyan V; Vicini S; Faden AI
Br J Pharmacol; 2000 Dec; 131(7):1429-37. PubMed ID: 11090117
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
