BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

490 related articles for article (PubMed ID: 16978743)

  • 1. Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.
    Jiang H; Wu YC; Nakamura M; Liang Y; Tanaka Y; Holmes S; Dawson VL; Dawson TM; Ross CA; Smith WW
    Neurobiol Aging; 2007 Nov; 28(11):1709-17. PubMed ID: 16978743
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.
    Smith WW; Jiang H; Pei Z; Tanaka Y; Morita H; Sawa A; Dawson VL; Dawson TM; Ross CA
    Hum Mol Genet; 2005 Dec; 14(24):3801-11. PubMed ID: 16239241
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.
    Lev N; Melamed E; Offen D
    Neurosci Lett; 2006 May; 399(1-2):27-32. PubMed ID: 16584840
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism.
    Liu Z; Yu Y; Li X; Ross CA; Smith WW
    Pharmacol Res; 2011 May; 63(5):439-44. PubMed ID: 21237271
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Differential effects of overexpression of wild-type and mutant human alpha-synuclein on MPP+-induced neurotoxicity in PC12 cells.
    Qian JJ; Cheng YB; Yang YP; Mao CJ; Qin ZH; Li K; Liu CF
    Neurosci Lett; 2008 Apr; 435(2):142-6. PubMed ID: 18342443
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.
    Yamashita H; Nakamura T; Takahashi T; Nagano Y; Hiji M; Hirabayashi T; Amano T; Yagi T; Sakai N; Kohriyama T; Matsumoto M
    J Neurochem; 2006 Jul; 98(1):45-56. PubMed ID: 16805795
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease.
    Lehmensiek V; Tan EM; Liebau S; Lenk T; Zettlmeisl H; Schwarz J; Storch A
    Neurochem Int; 2006 Apr; 48(5):329-40. PubMed ID: 16406146
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine.
    Moussa CE; Wersinger C; Tomita Y; Sidhu A
    Biochemistry; 2004 May; 43(18):5539-50. PubMed ID: 15122920
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K.
    Choong CJ; Say YH
    Neurotoxicology; 2011 Dec; 32(6):857-63. PubMed ID: 21658409
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells.
    Prasad JE; Kumar B; Andreatta C; Nahreini P; Hanson AJ; Yan XD; Prasad KN
    J Neurosci Res; 2004 May; 76(3):415-22. PubMed ID: 15079871
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Heredity in Parkinson's disease: new findings.
    Lev N; Melamed E
    Isr Med Assoc J; 2001 Jun; 3(6):435-8. PubMed ID: 11433638
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein.
    Marxreiter F; Nuber S; Kandasamy M; Klucken J; Aigner R; Burgmayer R; Couillard-Despres S; Riess O; Winkler J; Winner B
    Eur J Neurosci; 2009 Mar; 29(5):879-90. PubMed ID: 19291219
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.
    Halliday GM; Ophof A; Broe M; Jensen PH; Kettle E; Fedorow H; Cartwright MI; Griffiths FM; Shepherd CE; Double KL
    Brain; 2005 Nov; 128(Pt 11):2654-64. PubMed ID: 16000336
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease.
    Poon HF; Frasier M; Shreve N; Calabrese V; Wolozin B; Butterfield DA
    Neurobiol Dis; 2005 Apr; 18(3):492-8. PubMed ID: 15755676
    [TBL] [Abstract][Full Text] [Related]  

  • 15. alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.
    Shirakashi Y; Kawamoto Y; Tomimoto H; Takahashi R; Ihara M
    Acta Neuropathol; 2006 Dec; 112(6):681-9. PubMed ID: 16957925
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery.
    Lee VM; Trojanowski JQ
    Neuron; 2006 Oct; 52(1):33-8. PubMed ID: 17015225
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.
    Miller RM; Kiser GL; Kaysser-Kranich T; Casaceli C; Colla E; Lee MK; Palaniappan C; Federoff HJ
    Exp Neurol; 2007 Mar; 204(1):421-32. PubMed ID: 17254569
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death.
    Sun F; Anantharam V; Latchoumycandane C; Kanthasamy A; Kanthasamy AG
    J Pharmacol Exp Ther; 2005 Oct; 315(1):69-79. PubMed ID: 15987830
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells.
    Furukawa K; Matsuzaki-Kobayashi M; Hasegawa T; Kikuchi A; Sugeno N; Itoyama Y; Wang Y; Yao PJ; Bushlin I; Takeda A
    J Neurochem; 2006 May; 97(4):1071-7. PubMed ID: 16606366
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation.
    Schneider BL; Seehus CR; Capowski EE; Aebischer P; Zhang SC; Svendsen CN
    Hum Mol Genet; 2007 Mar; 16(6):651-66. PubMed ID: 17309880
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 25.