BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

92 related articles for article (PubMed ID: 16979338)

  • 1. 'Irreversible' slow-onset inhibition of orotate phosphoribosyltransferase by an amidrazone phosphate transition-state mimic.
    Witte JF; Bray KE; Thornburg CK; McClard RW
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6112-5. PubMed ID: 16979338
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Half-of-sites binding of orotidine 5'-phosphate and alpha-D-5-phosphorylribose 1-diphosphate to orotate phosphoribosyltransferase from Saccharomyces cerevisiae supports a novel variant of the Theorell-Chance mechanism with alternating site catalysis.
    McClard RW; Holets EA; MacKinnon AL; Witte JF
    Biochemistry; 2006 Apr; 45(16):5330-42. PubMed ID: 16618122
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase of human erythrocytes by purine and pyrimidine nucleotides.
    Tax WJ; Veerkamp JH
    Biochem Pharmacol; 1979 Mar; 28(6):829-31. PubMed ID: 454480
    [No Abstract]   [Full Text] [Related]  

  • 4. Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase.
    Harris LD; Harijan RK; Ducati RG; Evans GB; Hirsch BM; Schramm VL
    ACS Chem Biol; 2018 Jan; 13(1):152-160. PubMed ID: 29178779
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Orotate phosphoribosyltransferase (yeast).
    Yoshimoto A; Amaya T; Kobayashi K; Tomita K
    Methods Enzymol; 1978; 51():69-74. PubMed ID: 357907
    [No Abstract]   [Full Text] [Related]  

  • 6. Transition state structure of Salmonella typhimurium orotate phosphoribosyltransferase.
    Tao W; Grubmeyer C; Blanchard JS
    Biochemistry; 1996 Jan; 35(1):14-21. PubMed ID: 8555167
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Divalent metal ion activation of the yeast orotate phosphoribosyltransferase catalyzed reaction.
    Victor J; Leo-Mensah A; Sloan DL
    Biochemistry; 1979 Aug; 18(16):3597-604. PubMed ID: 224912
    [No Abstract]   [Full Text] [Related]  

  • 8. Cloning, overproduction, and purification of native and mutant recombinant yeast orotate phosphoribosyltransferase and the demonstration from magnetization inversion transfer that a proposed oxocarbocation intermediate does not have a kinetic lifetime.
    Witte JF; Tsou R; McClard RW
    Arch Biochem Biophys; 1999 Jan; 361(1):106-12. PubMed ID: 9882434
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of magnesium cations in the yeast orotate phosphoribosyltransferase catalyzed reaction. Mechanism of the inhibition by Cu++ and Ni++ ions.
    Dodin G; Lalart D; Dubois JE
    J Inorg Biochem; 1982 Jun; 16(3):201-13. PubMed ID: 7050303
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Orotate phosphoribosyltransferase from yeast: studies of the structure of the pyrimidine substrate binding site.
    Ashton RW; Strauss RS; Chung SH; Sloan DL
    Arch Biochem Biophys; 1989 Aug; 272(2):421-32. PubMed ID: 2665650
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Studies of the kinetic mechanism of orotate phosphoribosyltransferase from yeast.
    Victor J; Greenberg LB; Sloan DL
    J Biol Chem; 1979 Apr; 254(8):2647-55. PubMed ID: 218950
    [No Abstract]   [Full Text] [Related]  

  • 12. Determination of a histidine residue at the yeast orotate phosphoribosyltransferase active-site.
    Sloan DL; Strauss RS
    Adv Exp Med Biol; 1984; 165 Pt B():89-92. PubMed ID: 6372388
    [No Abstract]   [Full Text] [Related]  

  • 13. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase.
    González-Segura L; Witte JF; McClard RW; Hurley TD
    Biochemistry; 2007 Dec; 46(49):14075-86. PubMed ID: 18020427
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel UDP-glycal derivatives as transition state analogue inhibitors of UDP-GlcNAc 2-epimerase.
    Stolz F; Reiner M; Blume A; Reutter W; Schmidt RR
    J Org Chem; 2004 Feb; 69(3):665-79. PubMed ID: 14750790
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 31P-NMR study of the orotate phosphoribosyltransferase equilibrium with thiopyrophosphate as substrate.
    Tavares A; Lee CS; O'Sullivan WJ
    Biochim Biophys Acta; 1987 Jul; 913(3):279-84. PubMed ID: 3036235
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase.
    Breda A; Machado P; Rosado LA; Souto AA; Santos DS; Basso LA
    Eur J Med Chem; 2012 Aug; 54():113-22. PubMed ID: 22608674
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.
    Zhang Y; Schramm VL
    J Am Chem Soc; 2010 Jun; 132(25):8787-94. PubMed ID: 20527751
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Regulation of pyrimidine synthesis in Pseudomonas resinovorans.
    West TP
    Lett Appl Microbiol; 2005; 40(6):473-8. PubMed ID: 15892745
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Designing better coumarin-based fluorogenic substrates for PTP1B.
    Holmes CP; Macher N; Grove JR; Jang L; Irvine JD
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3382-5. PubMed ID: 18442911
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase.
    Walker SR; Parker EJ
    Bioorg Med Chem Lett; 2006 Jun; 16(11):2951-4. PubMed ID: 16563755
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.