These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

121 related articles for article (PubMed ID: 16979340)

  • 1. Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl derivatives.
    Kuo PY; Shie TL; Chen YS; Lai JT; Yang DY
    Bioorg Med Chem Lett; 2006 Dec; 16(23):6024-7. PubMed ID: 16979340
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA; Elrod K; Luong C; Rice MJ; Mackman RL; Sprengeler PA; Spencer J; Hataye J; Janc J; Link J; Litvak J; Rai R; Rice K; Sideris S; Verner E; Young W
    J Mol Biol; 2001 Apr; 307(5):1451-86. PubMed ID: 11292354
    [TBL] [Abstract][Full Text] [Related]  

  • 3. SAR studies of 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one as inhibitors of 4-hydroxyphenylpyruvate dioxygenase.
    Lin YL; Wu CS; Lin SW; Huang JL; Sun YS; Yang DY
    Bioorg Med Chem; 2002 Mar; 10(3):685-90. PubMed ID: 11814856
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies.
    Sperl S; Bergner A; Stürzebecher J; Magdolen V; Bode W; Moroder L
    Biol Chem; 2000 Apr; 381(4):321-9. PubMed ID: 10839461
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
    Hurt DE; Sutton AE; Clardy J
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1610-5. PubMed ID: 16406782
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Development of metal-chelating inhibitors for the Class II fructose 1,6-bisphosphate (FBP) aldolase.
    Labbé G; Krismanich AP; de Groot S; Rasmusson T; Shang M; Brown MD; Dmitrienko GI; Guillemette JG
    J Inorg Biochem; 2012 Jul; 112():49-58. PubMed ID: 22546686
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biaryl analogues of teriflunomide as potent DHODH inhibitors.
    Erra M; Moreno I; Sanahuja J; Andrés M; Reinoso RF; Lozoya E; Pizcueta P; Godessart N; Castro-Palomino JC
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7268-72. PubMed ID: 22078215
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mode of action of 4-hydroxyphenylpyruvate dioxygenase inhibition by triketone-type inhibitors.
    Wu CS; Huang JL; Sun YS; Yang DY
    J Med Chem; 2002 May; 45(11):2222-8. PubMed ID: 12014960
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate analogues as chelation-based inhibitors of methylerythritol phosphate synthase.
    Walker JR; Poulter CD
    J Org Chem; 2005 Nov; 70(24):9955-9. PubMed ID: 16292827
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC.
    Brownlee JM; Johnson-Winters K; Harrison DH; Moran GR
    Biochemistry; 2004 Jun; 43(21):6370-7. PubMed ID: 15157070
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.
    Magnin DR; Robl JA; Sulsky RB; Augeri DJ; Huang Y; Simpkins LM; Taunk PC; Betebenner DA; Robertson JG; Abboa-Offei BE; Wang A; Cap M; Xin L; Tao L; Sitkoff DF; Malley MF; Gougoutas JZ; Khanna A; Huang Q; Han SP; Parker RA; Hamann LG
    J Med Chem; 2004 May; 47(10):2587-98. PubMed ID: 15115400
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases.
    Yang C; Pflugrath JW; Camper DL; Foster ML; Pernich DJ; Walsh TA
    Biochemistry; 2004 Aug; 43(32):10414-23. PubMed ID: 15301540
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase.
    Long YQ; Jiang XH; Dayam R; Sanchez T; Shoemaker R; Sei S; Neamati N
    J Med Chem; 2004 May; 47(10):2561-73. PubMed ID: 15115398
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Co-crystal structure and inhibition of factor Xa by PD0313052 identifies structurally stabilized active site residues of factor Xa and prothrombinase.
    Gould WR; Cladera E; Harris MS; Zhang E; Narasimhan L; Thorn JM; Leadley RJ
    Biochemistry; 2005 Jul; 44(26):9280-9. PubMed ID: 15981994
    [TBL] [Abstract][Full Text] [Related]  

  • 15. (R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode.
    Mueller MM; Sperl S; Stürzebecher J; Bode W; Moroder L
    Biol Chem; 2002; 383(7-8):1185-91. PubMed ID: 12437104
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
    Heikkilä T; Thirumalairajan S; Davies M; Parsons MR; McConkey AG; Fishwick CW; Johnson AP
    Bioorg Med Chem Lett; 2006 Jan; 16(1):88-92. PubMed ID: 16236496
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase.
    Mbadugha BN; Seo J; Ji H; Martásek P; Roman LJ; Shea TM; Li H; Poulos TL; Silverman RB
    Bioorg Med Chem; 2006 Jun; 14(11):3681-90. PubMed ID: 16480878
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures.
    McLean LR; Zhang Y; Degnen W; Peppard J; Cabel D; Zou C; Tsay JT; Subramaniam A; Vaz RJ; Li Y
    Bioorg Med Chem Lett; 2010 Mar; 20(6):1981-4. PubMed ID: 20153645
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
    Hurt DE; Widom J; Clardy J
    Acta Crystallogr D Biol Crystallogr; 2006 Mar; 62(Pt 3):312-23. PubMed ID: 16510978
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Chelating ligand conformation driving the hypoxanthine metal binding patterns.
    Patel DK; Choquesillo-Lazarte D; Domínguez-Martín A; Brandi-Blanco MP; González-Pérez JM; Castiñeiras A; Niclós-Gutiérrez J
    Inorg Chem; 2011 Nov; 50(21):10549-51. PubMed ID: 21995280
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.