BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 16990004)

  • 1. Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase.
    Ding Y; Smith KL; Varaprasad CV; Chang E; Alexander J; Yao N
    Bioorg Med Chem Lett; 2007 Feb; 17(3):841-5. PubMed ID: 16990004
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors.
    Yan S; Appleby T; Larson G; Wu JZ; Hamatake R; Hong Z; Yao N
    Bioorg Med Chem Lett; 2006 Nov; 16(22):5888-91. PubMed ID: 16934455
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.
    Talele TT; Arora P; Kulkarni SS; Patel MR; Singh S; Chudayeu M; Kaushik-Basu N
    Bioorg Med Chem; 2010 Jul; 18(13):4630-8. PubMed ID: 20627595
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure.
    Yan S; Larson G; Wu JZ; Appleby T; Ding Y; Hamatake R; Hong Z; Yao N
    Bioorg Med Chem Lett; 2007 Jan; 17(1):63-7. PubMed ID: 17049849
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors.
    Zhao C; Wang Y; Ma S
    Eur J Med Chem; 2015 Sep; 102():188-214. PubMed ID: 26276434
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.
    Krueger AC; Madigan DL; Jiang WW; Kati WM; Liu D; Liu Y; Maring CJ; Masse S; McDaniel KF; Middleton T; Mo H; Molla A; Montgomery D; Pratt JK; Rockway TW; Zhang R; Kempf DJ
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3367-70. PubMed ID: 16650764
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
    Çakir G; Küçükgüzel İ; Guhamazumder R; Tatar E; Manvar D; Basu A; Patel BA; Zia J; Talele TT; Kaushik-Basu N
    Arch Pharm (Weinheim); 2015 Jan; 348(1):10-22. PubMed ID: 25449674
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor.
    Barnes DM; Shekhar S; Dunn TB; Barkalow JH; Chan VS; Franczyk TS; Haight AR; Hengeveld JE; Kolaczkowski L; Kotecki BJ; Liang G; Marek JC; McLaughlin MA; Montavon DK; Napier JJ
    J Org Chem; 2019 Apr; 84(8):4873-4892. PubMed ID: 30629443
    [TBL] [Abstract][Full Text] [Related]  

  • 9. HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives.
    Wang G; He Y; Sun J; Das D; Hu M; Huang J; Ruhrmund D; Hooi L; Misialek S; Ravi Rajagopalan PT; Stoycheva A; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4476-9. PubMed ID: 19502055
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Isothiazoles as active-site inhibitors of HCV NS5B polymerase.
    Yan S; Appleby T; Gunic E; Shim JH; Tasu T; Kim H; Rong F; Chen H; Hamatake R; Wu JZ; Hong Z; Yao N
    Bioorg Med Chem Lett; 2007 Jan; 17(1):28-33. PubMed ID: 17049853
    [TBL] [Abstract][Full Text] [Related]  

  • 11. HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives.
    Wang G; Zhang L; Wu X; Das D; Ruhrmund D; Hooi L; Misialek S; Ravi Rajagopalan PT; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4484-7. PubMed ID: 19497737
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular design and synthesis of HCV inhibitors based on thiazolone scaffold.
    Al-Ansary GH; Ismail MA; Abou El Ella DA; Eid S; Abouzid KA
    Eur J Med Chem; 2013 Oct; 68():19-32. PubMed ID: 23933047
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
    Hendricks RT; Fell JB; Blake JF; Fischer JP; Robinson JE; Spencer SR; Stengel PJ; Bernacki AL; Leveque VJ; Le Pogam S; Rajyaguru S; Najera I; Josey JA; Harris JR; Swallow S
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3637-41. PubMed ID: 19447623
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: convergence of structure-based drug design and X-ray crystallographic study.
    Yan S; Appleby T; Larson G; Wu JZ; Hamatake RK; Hong Z; Yao N
    Bioorg Med Chem Lett; 2007 Apr; 17(7):1991-5. PubMed ID: 17276060
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates.
    Malancona S; Donghi M; Ferrara M; Martin Hernando JI; Pompei M; Pesci S; Ontoria JM; Koch U; Rowley M; Summa V
    Bioorg Med Chem; 2010 Apr; 18(8):2836-48. PubMed ID: 20363140
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.
    Gopalsamy A; Chopra R; Lim K; Ciszewski G; Shi M; Curran KJ; Sukits SF; Svenson K; Bard J; Ellingboe JW; Agarwal A; Krishnamurthy G; Howe AY; Orlowski M; Feld B; O'Connell J; Mansour TS
    J Med Chem; 2006 Jun; 49(11):3052-5. PubMed ID: 16722622
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-based library design in efficient discovery of novel inhibitors.
    Yan S; Selliah R
    Methods Mol Biol; 2011; 685():175-90. PubMed ID: 20981524
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Anti-hepatitis-C virus activity and QSAR study of certain thiazolidinone and thiazolotriazine derivatives as potential NS5B polymerase inhibitors.
    Hassan GS; Georgey HH; Mohammed EZ; Omar FA
    Eur J Med Chem; 2019 Dec; 184():111747. PubMed ID: 31604164
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase.
    LaPorte MG; Draper TL; Miller LE; Blackledge CW; Leister LK; Amparo E; Hussey AR; Young DC; Chunduru SK; Benetatos CA; Rhodes G; Gopalsamy A; Herbertz T; Burns CJ; Condon SM
    Bioorg Med Chem Lett; 2010 May; 20(9):2968-73. PubMed ID: 20347591
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
    Yang H; Hendricks RT; Arora N; Nitzan D; Yee C; Lucas MC; Yang Y; Fung A; Rajyaguru S; Harris SF; Leveque VJ; Hang JQ; Pogam SL; Reuter D; Tavares GA
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4614-9. PubMed ID: 20584604
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.