243 related articles for article (PubMed ID: 17000671)
1. Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation.
Jones DT; Pugh CW; Wigfield S; Stevens MF; Harris AL
Clin Cancer Res; 2006 Sep; 12(18):5384-94. PubMed ID: 17000671
[TBL] [Abstract][Full Text] [Related]
2. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
Welsh SJ; Williams RR; Birmingham A; Newman DJ; Kirkpatrick DL; Powis G
Mol Cancer Ther; 2003 Mar; 2(3):235-43. PubMed ID: 12657718
[TBL] [Abstract][Full Text] [Related]
3. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.
Welsh SJ; Bellamy WT; Briehl MM; Powis G
Cancer Res; 2002 Sep; 62(17):5089-95. PubMed ID: 12208766
[TBL] [Abstract][Full Text] [Related]
4. Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding.
Jones DT; Harris AL
Mol Cancer Ther; 2006 Sep; 5(9):2193-202. PubMed ID: 16985052
[TBL] [Abstract][Full Text] [Related]
5. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.
Rapisarda A; Uranchimeg B; Scudiero DA; Selby M; Sausville EA; Shoemaker RH; Melillo G
Cancer Res; 2002 Aug; 62(15):4316-24. PubMed ID: 12154035
[TBL] [Abstract][Full Text] [Related]
6. Activation of hypoxia-induced transcription in normoxia.
Hägg M; Wennström S
Exp Cell Res; 2005 May; 306(1):180-91. PubMed ID: 15878343
[TBL] [Abstract][Full Text] [Related]
7. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.
Hudson CC; Liu M; Chiang GG; Otterness DM; Loomis DC; Kaper F; Giaccia AJ; Abraham RT
Mol Cell Biol; 2002 Oct; 22(20):7004-14. PubMed ID: 12242281
[TBL] [Abstract][Full Text] [Related]
8. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells.
Mabjeesh NJ; Willard MT; Frederickson CE; Zhong H; Simons JW
Clin Cancer Res; 2003 Jul; 9(7):2416-25. PubMed ID: 12855613
[TBL] [Abstract][Full Text] [Related]
9. Antitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase.
Kim YH; Coon A; Baker AF; Powis G
Cancer Chemother Pharmacol; 2011 Aug; 68(2):405-13. PubMed ID: 21069338
[TBL] [Abstract][Full Text] [Related]
10. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
Blancher C; Moore JW; Robertson N; Harris AL
Cancer Res; 2001 Oct; 61(19):7349-55. PubMed ID: 11585776
[TBL] [Abstract][Full Text] [Related]
11. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Wiesener MS; Turley H; Allen WE; Willam C; Eckardt KU; Talks KL; Wood SM; Gatter KC; Harris AL; Pugh CW; Ratcliffe PJ; Maxwell PH
Blood; 1998 Oct; 92(7):2260-8. PubMed ID: 9746763
[TBL] [Abstract][Full Text] [Related]
12. Antisense-thioredoxin inhibits angiogenesis via pVHL-mediated hypoxia-inducible factor-1alpha degradation.
Kim WJ; Cho H; Lee SW; Kim YJ; Kim KW
Int J Oncol; 2005 Apr; 26(4):1049-52. PubMed ID: 15754001
[TBL] [Abstract][Full Text] [Related]
13. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
Forsythe JA; Jiang BH; Iyer NV; Agani F; Leung SW; Koos RD; Semenza GL
Mol Cell Biol; 1996 Sep; 16(9):4604-13. PubMed ID: 8756616
[TBL] [Abstract][Full Text] [Related]
14. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension.
Jiang BH; Zheng JZ; Leung SW; Roe R; Semenza GL
J Biol Chem; 1997 Aug; 272(31):19253-60. PubMed ID: 9235919
[TBL] [Abstract][Full Text] [Related]
15. Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway.
Carroll VA; Ashcroft M
Cancer Res; 2006 Jun; 66(12):6264-70. PubMed ID: 16778202
[TBL] [Abstract][Full Text] [Related]
16. Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines.
Blancher C; Moore JW; Talks KL; Houlbrook S; Harris AL
Cancer Res; 2000 Dec; 60(24):7106-13. PubMed ID: 11156418
[TBL] [Abstract][Full Text] [Related]
17. Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.
Puppo M; Battaglia F; Ottaviano C; Delfino S; Ribatti D; Varesio L; Bosco MC
Mol Cancer Ther; 2008 Jul; 7(7):1974-84. PubMed ID: 18645007
[TBL] [Abstract][Full Text] [Related]
18. Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain.
Maemura K; Hsieh CM; Jain MK; Fukumoto S; Layne MD; Liu Y; Kourembanas S; Yet SF; Perrella MA; Lee ME
J Biol Chem; 1999 Oct; 274(44):31565-70. PubMed ID: 10531360
[TBL] [Abstract][Full Text] [Related]
19. Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
Tan C; de Noronha RG; Roecker AJ; Pyrzynska B; Khwaja F; Zhang Z; Zhang H; Teng Q; Nicholson AC; Giannakakou P; Zhou W; Olson JJ; Pereira MM; Nicolaou KC; Van Meir EG
Cancer Res; 2005 Jan; 65(2):605-12. PubMed ID: 15695405
[TBL] [Abstract][Full Text] [Related]
20. Co-transactivation of the 3' erythropoietin hypoxia inducible enhancer by the HIF-1 protein.
Varma S; Cohen HJ
Blood Cells Mol Dis; 1997 Aug; 23(2):169-76. PubMed ID: 9236155
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
