BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

586 related articles for article (PubMed ID: 17000690)

  • 1. The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1.
    Barkan B; Starinsky S; Friedman E; Stein R; Kloog Y
    Clin Cancer Res; 2006 Sep; 12(18):5533-42. PubMed ID: 17000690
    [TBL] [Abstract][Full Text] [Related]  

  • 2. New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models.
    Goldberg L; Haklai R; Bauer V; Heiss A; Kloog Y
    J Med Chem; 2009 Jan; 52(1):197-205. PubMed ID: 19072665
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.
    Shapira S; Barkan B; Friedman E; Kloog Y; Stein R
    Cell Death Differ; 2007 May; 14(5):895-906. PubMed ID: 17096025
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
    Rotblat B; Ehrlich M; Haklai R; Kloog Y
    Methods Enzymol; 2008; 439():467-89. PubMed ID: 18374183
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats.
    da Silva Morais A; Saliez A; Leclercq I; Horsmans Y; Stärkel P
    Clin Sci (Lond); 2008 Jan; 114(1):73-83. PubMed ID: 17678500
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype.
    Yan N; Ricca C; Fletcher J; Glover T; Seizinger BR; Manne V
    Cancer Res; 1995 Aug; 55(16):3569-75. PubMed ID: 7627966
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid).
    Blum R; Elkon R; Yaari S; Zundelevich A; Jacob-Hirsch J; Rechavi G; Shamir R; Kloog Y
    Cancer Res; 2007 Apr; 67(7):3320-8. PubMed ID: 17409441
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor.
    George J; Sack J; Barshack I; Keren P; Goldberg I; Haklai R; Elad-Sfadia G; Kloog Y; Keren G
    Arterioscler Thromb Vasc Biol; 2004 Feb; 24(2):363-8. PubMed ID: 14670932
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling.
    Barkan B; Kloog Y; Ehrlich M
    Mol Cancer Ther; 2011 Aug; 10(8):1317-26. PubMed ID: 21632464
    [TBL] [Abstract][Full Text] [Related]  

  • 10. NF1 deficiency causes Bcl-xL upregulation in Schwann cells derived from neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.
    Park HJ; Lee SJ; Sohn YB; Jin HS; Han JH; Kim YB; Yim H; Jeong SY
    Int J Oncol; 2013 Feb; 42(2):657-66. PubMed ID: 23292448
    [TBL] [Abstract][Full Text] [Related]  

  • 11. MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1.
    Chai G; Liu N; Ma J; Li H; Oblinger JL; Prahalad AK; Gong M; Chang LS; Wallace M; Muir D; Guha A; Phipps RJ; Hock JM; Yu X
    Cancer Sci; 2010 Sep; 101(9):1997-2004. PubMed ID: 20550523
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice.
    Mor A; Kloog Y; Keren G; George J
    Eur J Pharmacol; 2009 Aug; 616(1-3):301-5. PubMed ID: 19527709
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).
    Hirokawa Y; Levitzki A; Lessene G; Baell J; Xiao Y; Zhu H; Maruta H
    Cancer Lett; 2007 Jan; 245(1-2):242-51. PubMed ID: 16540233
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death.
    Blum R; Jacob-Hirsch J; Amariglio N; Rechavi G; Kloog Y
    Cancer Res; 2005 Feb; 65(3):999-1006. PubMed ID: 15705901
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A mouse embryonic stem cell model of Schwann cell differentiation for studies of the role of neurofibromatosis type 1 in Schwann cell development and tumor formation.
    Roth TM; Ramamurthy P; Ebisu F; Lisak RP; Bealmear BM; Barald KF
    Glia; 2007 Aug; 55(11):1123-33. PubMed ID: 17597122
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular characterization of permanent cell lines from primary, metastatic and recurrent malignant peripheral nerve sheath tumors (MPNST) with underlying neurofibromatosis-1.
    Fang Y; Elahi A; Denley RC; Rao PH; Brennan MF; Jhanwar SC
    Anticancer Res; 2009 Apr; 29(4):1255-62. PubMed ID: 19414372
    [TBL] [Abstract][Full Text] [Related]  

  • 17. RAS/MEK-independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST.
    Sun D; Haddad R; Kraniak JM; Horne SD; Tainsky MA
    Mol Cancer Res; 2013 Jun; 11(6):616-27. PubMed ID: 23423222
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model.
    Shohami E; Yatsiv I; Alexandrovich A; Haklai R; Elad-Sfadia G; Grossman R; Biegon A; Kloog Y
    J Cereb Blood Flow Metab; 2003 Jun; 23(6):728-38. PubMed ID: 12796721
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PACAP and VIP affect NF1 expression in rat malignant peripheral nerve sheath tumor (MPNST) cells.
    Giunta S; Castorina A; Adorno A; Mazzone V; Carnazza ML; D'Agata V
    Neuropeptides; 2010 Feb; 44(1):45-51. PubMed ID: 19919880
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes.
    Kim HA; Rosenbaum T; Marchionni MA; Ratner N; DeClue JE
    Oncogene; 1995 Jul; 11(2):325-35. PubMed ID: 7624147
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 30.