BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

297 related articles for article (PubMed ID: 17005902)

  • 1. In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs.
    Hawes BE; O'neill KA; Yao X; Crona JH; Davis HR; Graziano MP; Altmann SW
    Mol Pharmacol; 2007 Jan; 71(1):19-29. PubMed ID: 17005902
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.
    Ge L; Wang J; Qi W; Miao HH; Cao J; Qu YX; Li BL; Song BL
    Cell Metab; 2008 Jun; 7(6):508-19. PubMed ID: 18522832
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Niemann-pick C1-like 1 mediates alpha-tocopherol transport.
    Narushima K; Takada T; Yamanashi Y; Suzuki H
    Mol Pharmacol; 2008 Jul; 74(1):42-9. PubMed ID: 18403720
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.
    Altmann SW; Davis HR; Zhu LJ; Yao X; Hoos LM; Tetzloff G; Iyer SP; Maguire M; Golovko A; Zeng M; Wang L; Murgolo N; Graziano MP
    Science; 2004 Feb; 303(5661):1201-4. PubMed ID: 14976318
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
    Garcia-Calvo M; Lisnock J; Bull HG; Hawes BE; Burnett DA; Braun MP; Crona JH; Davis HR; Dean DC; Detmers PA; Graziano MP; Hughes M; Macintyre DE; Ogawa A; O'neill KA; Iyer SP; Shevell DE; Smith MM; Tang YS; Makarewicz AM; Ujjainwalla F; Altmann SW; Chapman KT; Thornberry NA
    Proc Natl Acad Sci U S A; 2005 Jun; 102(23):8132-7. PubMed ID: 15928087
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells.
    Yamanashi Y; Takada T; Suzuki H
    J Pharmacol Exp Ther; 2007 Feb; 320(2):559-64. PubMed ID: 17135346
    [TBL] [Abstract][Full Text] [Related]  

  • 7. NPC1L1: evolution from pharmacological target to physiological sterol transporter.
    Huff MW; Pollex RL; Hegele RA
    Arterioscler Thromb Vasc Biol; 2006 Nov; 26(11):2433-8. PubMed ID: 16973966
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The structure and function of Niemann-Pick C1-like 1 protein.
    Yu L
    Curr Opin Lipidol; 2008 Jun; 19(3):263-9. PubMed ID: 18460917
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of intestinal cholesterol absorption by ezetimibe is a novel therapeutic target for fatty liver.
    Yamagishi S; Nakamura K; Matsui T; Sato T; Takeuchi M
    Med Hypotheses; 2006; 66(4):844-6. PubMed ID: 16188393
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cholesterol-lowering effect of ezetimibe in uridine diphosphate glucuronosyltransferase 1A-deficient (Gunn) rats.
    Yamamoto T; Ito K; Honma M; Takada T; Suzuki H
    Drug Metab Dispos; 2007 Sep; 35(9):1455-8. PubMed ID: 17567728
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake.
    Weinglass AB; Köhler MG; Nketiah EO; Liu J; Schmalhofer W; Thomas A; Williams B; Beers L; Smith L; Hafey M; Bleasby K; Leone J; Tang YS; Braun M; Ujjainwalla F; McCann ME; Kaczorowski GJ; Garcia ML
    Mol Pharmacol; 2008 Apr; 73(4):1072-84. PubMed ID: 18187582
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Spiroimidazolidinone NPC1L1 inhibitors. Part 2: structure-activity studies and in vivo efficacy.
    Howell KL; DeVita RJ; Garcia-Calvo M; Meurer RD; Lisnock J; Bull HG; McMasters DR; McCann ME; Mills SG
    Bioorg Med Chem Lett; 2010 Dec; 20(23):6929-32. PubMed ID: 21030254
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Transporters as drug targets: discovery and development of NPC1L1 inhibitors.
    Betters JL; Yu L
    Clin Pharmacol Ther; 2010 Jan; 87(1):117-21. PubMed ID: 19907422
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hepatic Niemann-Pick C1-like 1.
    Pramfalk C; Jiang ZY; Parini P
    Curr Opin Lipidol; 2011 Jun; 22(3):225-30. PubMed ID: 21494140
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe.
    Wang J; Williams CM; Hegele RA
    Clin Genet; 2005 Feb; 67(2):175-7. PubMed ID: 15679830
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cholesterol homeostasis by the intestine: lessons from Niemann-Pick C1 Like 1 [NPC1L1).
    Davis HR; Basso F; Hoos LM; Tetzloff G; Lally SM; Altmann SW
    Atheroscler Suppl; 2008 Sep; 9(2):77-81. PubMed ID: 18585981
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.
    Labonté ED; Howles PN; Granholm NA; Rojas JC; Davies JP; Ioannou YA; Hui DY
    Biochim Biophys Acta; 2007 Sep; 1771(9):1132-9. PubMed ID: 17442616
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Extracellular loop C of NPC1L1 is important for binding to ezetimibe.
    Weinglass AB; Kohler M; Schulte U; Liu J; Nketiah EO; Thomas A; Schmalhofer W; Williams B; Bildl W; McMasters DR; Dai K; Beers L; McCann ME; Kaczorowski GJ; Garcia ML
    Proc Natl Acad Sci U S A; 2008 Aug; 105(32):11140-5. PubMed ID: 18682566
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance.
    Nomura M; Ishii H; Kawakami A; Yoshida M
    Am J Physiol Endocrinol Metab; 2009 Nov; 297(5):E1030-8. PubMed ID: 19654286
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.
    Knöpfel M; Davies JP; Duong PT; Kvaernø L; Carreira EM; Phillips MC; Ioannou YA; Hauser H
    Biochim Biophys Acta; 2007 Sep; 1771(9):1140-7. PubMed ID: 17689140
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.