BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

596 related articles for article (PubMed ID: 17018606)

  • 1. Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.
    Chandler DS; Singh RK; Caldwell LC; Bitler JL; Lozano G
    Cancer Res; 2006 Oct; 66(19):9502-8. PubMed ID: 17018606
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.
    Zhang Q; He X; Chen L; Zhang C; Gao X; Yang Z; Liu G
    J Pathol; 2012 Nov; 228(3):416-28. PubMed ID: 22821713
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity.
    Giglio S; Mancini F; Pellegrino M; Di Conza G; Puxeddu E; Sacchi A; Pontecorvi A; Moretti F
    Oncogene; 2010 Nov; 29(44):5935-45. PubMed ID: 20697359
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4.
    Fan C; Wang X
    Cell Cycle; 2017 Apr; 16(7):660-664. PubMed ID: 28166445
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.
    Steinman HA; Hoover KM; Keeler ML; Sands AT; Jones SN
    Oncogene; 2005 Nov; 24(53):7935-40. PubMed ID: 16027727
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of hdm2 by stress-induced hdm2alt1 in tumor and nontumorigenic cell lines correlating with p53 stability.
    Dias CS; Liu Y; Yau A; Westrick L; Evans SC
    Cancer Res; 2006 Oct; 66(19):9467-73. PubMed ID: 17018602
    [TBL] [Abstract][Full Text] [Related]  

  • 7. MDM2 and MDM4 splicing: an integral part of the cancer spliceome.
    Jeyaraj S; O'Brien DM; Chandler DS
    Front Biosci (Landmark Ed); 2009 Jan; 14(7):2647-56. PubMed ID: 19273224
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
    Grier JD; Xiong S; Elizondo-Fraire AC; Parant JM; Lozano G
    Mol Cell Biol; 2006 Jan; 26(1):192-8. PubMed ID: 16354690
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma.
    Jacob AG; O'Brien D; Singh RK; Comiskey DF; Littleton RM; Mohammad F; Gladman JT; Widmann MC; Jeyaraj SC; Bolinger C; Anderson JR; Barkauskas DA; Boris-Lawrie K; Chandler DS
    Neoplasia; 2013 Sep; 15(9):1049-63. PubMed ID: 24027430
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mdm2 and Mdm4 loss regulates distinct p53 activities.
    Barboza JA; Iwakuma T; Terzian T; El-Naggar AK; Lozano G
    Mol Cancer Res; 2008 Jun; 6(6):947-54. PubMed ID: 18567799
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.
    Toledo F; Krummel KA; Lee CJ; Liu CW; Rodewald LW; Tang M; Wahl GM
    Cancer Cell; 2006 Apr; 9(4):273-85. PubMed ID: 16616333
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Alternative and aberrant messenger RNA splicing of the mdm2 oncogene in invasive breast cancer.
    Lukas J; Gao DQ; Keshmeshian M; Wen WH; Tsao-Wei D; Rosenberg S; Press MF
    Cancer Res; 2001 Apr; 61(7):3212-9. PubMed ID: 11306511
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mdm2 and MdmX involvement in human cancer.
    Berberich SJ
    Subcell Biochem; 2014; 85():263-80. PubMed ID: 25201200
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.
    Parant J; Chavez-Reyes A; Little NA; Yan W; Reinke V; Jochemsen AG; Lozano G
    Nat Genet; 2001 Sep; 29(1):92-5. PubMed ID: 11528400
    [TBL] [Abstract][Full Text] [Related]  

  • 15. MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.
    Mancini F; Pieroni L; Monteleone V; Lucà R; Fici L; Luca E; Urbani A; Xiong S; Soddu S; Masetti R; Lozano G; Pontecorvi A; Moretti F
    Oncogene; 2016 Jan; 35(2):228-40. PubMed ID: 25961923
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.
    Iwakuma T; Parant JM; Fasulo M; Zwart E; Jacks T; de Vries A; Lozano G
    Oncogene; 2004 Oct; 23(46):7644-50. PubMed ID: 15361844
    [TBL] [Abstract][Full Text] [Related]  

  • 17. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
    Chen L; Gilkes DM; Pan Y; Lane WS; Chen J
    EMBO J; 2005 Oct; 24(19):3411-22. PubMed ID: 16163388
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
    Pereg Y; Shkedy D; de Graaf P; Meulmeester E; Edelson-Averbukh M; Salek M; Biton S; Teunisse AF; Lehmann WD; Jochemsen AG; Shiloh Y
    Proc Natl Acad Sci U S A; 2005 Apr; 102(14):5056-61. PubMed ID: 15788536
    [TBL] [Abstract][Full Text] [Related]  

  • 19. MDM4 is a key therapeutic target in cutaneous melanoma.
    Gembarska A; Luciani F; Fedele C; Russell EA; Dewaele M; Villar S; Zwolinska A; Haupt S; de Lange J; Yip D; Goydos J; Haigh JJ; Haupt Y; Larue L; Jochemsen A; Shi H; Moriceau G; Lo RS; Ghanem G; Shackleton M; Bernal F; Marine JC
    Nat Med; 2012 Aug; 18(8):1239-47. PubMed ID: 22820643
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response.
    Park DE; Cheng J; Berrios C; Montero J; Cortés-Cros M; Ferretti S; Arora R; Tillgren ML; Gokhale PC; DeCaprio JA
    Proc Natl Acad Sci U S A; 2019 Jan; 116(3):1027-1032. PubMed ID: 30598450
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 30.