These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 17027909)

  • 1. Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme.
    Hernandez CE; Kumar S; Liu H; Halpert JR
    Arch Biochem Biophys; 2006 Nov; 455(1):61-7. PubMed ID: 17027909
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme.
    Wilderman PR; Gay SC; Jang HH; Zhang Q; Stout CD; Halpert JR
    FEBS J; 2012 May; 279(9):1607-20. PubMed ID: 22051155
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
    Zhao Y; White MA; Muralidhara BK; Sun L; Halpert JR; Stout CD
    J Biol Chem; 2006 Mar; 281(9):5973-81. PubMed ID: 16373351
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Thermodynamic fidelity of the mammalian cytochrome P450 2B4 active site in binding substrates and inhibitors.
    Muralidhara BK; Sun L; Negi S; Halpert JR
    J Mol Biol; 2008 Mar; 377(1):232-45. PubMed ID: 18241887
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.
    Oezguen N; Kumar S; Hindupur A; Braun W; Muralidhara BK; Halpert JR
    J Biol Chem; 2008 Aug; 283(31):21808-16. PubMed ID: 18495666
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
    Sun L; Chen CS; Waxman DJ; Liu H; Halpert JR; Kumar S
    Arch Biochem Biophys; 2007 Feb; 458(2):167-74. PubMed ID: 17254539
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
    Gay SC; Sun L; Maekawa K; Halpert JR; Stout CD
    Biochemistry; 2009 Jun; 48(22):4762-71. PubMed ID: 19397311
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding.
    Scott EE; White MA; He YA; Johnson EF; Stout CD; Halpert JR
    J Biol Chem; 2004 Jun; 279(26):27294-301. PubMed ID: 15100217
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes.
    Jang HH; Davydov DR; Lee GY; Yun CH; Halpert JR
    Arch Biochem Biophys; 2014 Mar; 545():100-7. PubMed ID: 24445070
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
    Zhao Y; Sun L; Muralidhara BK; Kumar S; White MA; Stout CD; Halpert JR
    Biochemistry; 2007 Oct; 46(41):11559-67. PubMed ID: 17887776
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling.
    Muralidhara BK; Negi S; Chin CC; Braun W; Halpert JR
    J Biol Chem; 2006 Mar; 281(12):8051-61. PubMed ID: 16439365
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.
    Liu J; Shah MB; Zhang Q; Stout CD; Halpert JR; Wilderman PR
    Biochemistry; 2016 Apr; 55(13):1997-2007. PubMed ID: 26982502
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.
    Gay SC; Shah MB; Talakad JC; Maekawa K; Roberts AG; Wilderman PR; Sun L; Yang JY; Huelga SC; Hong WX; Zhang Q; Stout CD; Halpert JR
    Mol Pharmacol; 2010 Apr; 77(4):529-38. PubMed ID: 20061448
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling.
    Spatzenegger M; Liu H; Wang Q; Debarber A; Koop DR; Halpert JR
    J Pharmacol Exp Ther; 2003 Jan; 304(1):477-87. PubMed ID: 12490624
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
    Hasler JA; Harlow GR; Szklarz GD; John GH; Kedzie KM; Burnett VL; He YA; Kaminsky LS; Halpert JR
    Mol Pharmacol; 1994 Aug; 46(2):338-45. PubMed ID: 8078495
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide.
    Kumar S; Chen CS; Waxman DJ; Halpert JR
    J Biol Chem; 2005 May; 280(20):19569-75. PubMed ID: 15774478
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chimeric cDNA expression and site directed mutagenesis studies of cytochrome P450s CYP2A1 and CYP2A2.
    Hanioka N; Gonzalez FJ; Lindberg NA; Liu G; Korzekwa KR
    J Steroid Biochem Mol Biol; 1992 Dec; 43(8):1037-43. PubMed ID: 22217848
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Functional role of residues in the helix B' region of cytochrome P450 2B1.
    Honma W; Li W; Liu H; Scott EE; Halpert JR
    Arch Biochem Biophys; 2005 Mar; 435(1):157-65. PubMed ID: 15680917
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography.
    Wilderman PR; Shah MB; Liu T; Li S; Hsu S; Roberts AG; Goodlett DR; Zhang Q; Woods VL; Stout CD; Halpert JR
    J Biol Chem; 2010 Dec; 285(49):38602-11. PubMed ID: 20880847
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9.
    Mosher CM; Hummel MA; Tracy TS; Rettie AE
    Biochemistry; 2008 Nov; 47(45):11725-34. PubMed ID: 18922023
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.