BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

237 related articles for article (PubMed ID: 17034121)

  • 1. Acylguanidines as small-molecule beta-secretase inhibitors.
    Cole DC; Manas ES; Stock JR; Condon JS; Jennings LD; Aulabaugh A; Chopra R; Cowling R; Ellingboe JW; Fan KY; Harrison BL; Hu Y; Jacobsen S; Jin G; Lin L; Lovering FE; Malamas MS; Stahl ML; Strand J; Sukhdeo MN; Svenson K; Turner MJ; Wagner E; Wu J; Zhou P; Bard J
    J Med Chem; 2006 Oct; 49(21):6158-61. PubMed ID: 17034121
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.
    Malamas MS; Barnes K; Hui Y; Johnson M; Lovering F; Condon J; Fobare W; Solvibile W; Turner J; Hu Y; Manas ES; Fan K; Olland A; Chopra R; Bard J; Pangalos MN; Reinhart P; Robichaud AJ
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2068-73. PubMed ID: 20223661
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
    Malamas MS; Erdei J; Gunawan I; Turner J; Hu Y; Wagner E; Fan K; Chopra R; Olland A; Bard J; Jacobsen S; Magolda RL; Pangalos M; Robichaud AJ
    J Med Chem; 2010 Feb; 53(3):1146-58. PubMed ID: 19968289
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
    Cole DC; Stock JR; Chopra R; Cowling R; Ellingboe JW; Fan KY; Harrison BL; Hu Y; Jacobsen S; Jennings LD; Jin G; Lohse PA; Malamas MS; Manas ES; Moore WJ; O'Donnell MM; Olland AM; Robichaud AJ; Svenson K; Wu J; Wagner E; Bard J
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1063-6. PubMed ID: 18162398
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.
    Coburn CA; Stachel SJ; Li YM; Rush DM; Steele TG; Chen-Dodson E; Holloway MK; Xu M; Huang Q; Lai MT; DiMuzio J; Crouthamel MC; Shi XP; Sardana V; Chen Z; Munshi S; Kuo L; Makara GM; Annis DA; Tadikonda PK; Nash HM; Vacca JP; Wang T
    J Med Chem; 2004 Dec; 47(25):6117-9. PubMed ID: 15566281
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.
    Xu Y; Li MJ; Greenblatt H; Chen W; Paz A; Dym O; Peleg Y; Chen T; Shen X; He J; Jiang H; Silman I; Sussman JL
    Acta Crystallogr D Biol Crystallogr; 2012 Jan; 68(Pt 1):13-25. PubMed ID: 22194329
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.
    Zhu Z; Sun ZY; Ye Y; Voigt J; Strickland C; Smith EM; Cumming J; Wang L; Wong J; Wang YS; Wyss DF; Chen X; Kuvelkar R; Kennedy ME; Favreau L; Parker E; McKittrick BA; Stamford A; Czarniecki M; Greenlee W; Hunter JC
    J Med Chem; 2010 Feb; 53(3):951-65. PubMed ID: 20043696
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Thiophene substituted acylguanidines as BACE1 inhibitors.
    Fobare WF; Solvibile WR; Robichaud AJ; Malamas MS; Manas E; Turner J; Hu Y; Wagner E; Chopra R; Cowling R; Jin G; Bard J
    Bioorg Med Chem Lett; 2007 Oct; 17(19):5353-6. PubMed ID: 17761418
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors.
    Malamas MS; Erdei J; Gunawan I; Barnes K; Johnson M; Hui Y; Turner J; Hu Y; Wagner E; Fan K; Olland A; Bard J; Robichaud AJ
    J Med Chem; 2009 Oct; 52(20):6314-23. PubMed ID: 19757823
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
    Shaw D; Best J; Dinnell K; Nadin A; Shearman M; Pattison C; Peachey J; Reilly M; Williams B; Wrigley J; Harrison T
    Bioorg Med Chem Lett; 2006 Jun; 16(11):3073-7. PubMed ID: 16617016
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase.
    Hom RK; Gailunas AF; Mamo S; Fang LY; Tung JS; Walker DE; Davis D; Thorsett ED; Jewett NE; Moon JB; John V
    J Med Chem; 2004 Jan; 47(1):158-64. PubMed ID: 14695829
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fragment-based discovery of BACE1 inhibitors using functional assays.
    Godemann R; Madden J; Krämer J; Smith M; Fritz U; Hesterkamp T; Barker J; Höppner S; Hallett D; Cesura A; Ebneth A; Kemp J
    Biochemistry; 2009 Nov; 48(45):10743-51. PubMed ID: 19799414
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors.
    Zou Y; Li L; Chen W; Chen T; Ma L; Wang X; Xiong B; Xu Y; Shen J
    Molecules; 2013 May; 18(5):5706-22. PubMed ID: 23681056
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
    Nowak P; Cole DC; Aulabaugh A; Bard J; Chopra R; Cowling R; Fan KY; Hu B; Jacobsen S; Jani M; Jin G; Lo MC; Malamas MS; Manas ES; Narasimhan R; Reinhart P; Robichaud AJ; Stock JR; Subrath J; Svenson K; Turner J; Wagner E; Zhou P; Ellingboe JW
    Bioorg Med Chem Lett; 2010 Jan; 20(2):632-5. PubMed ID: 19959359
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
    Iserloh U; Wu Y; Cumming JN; Pan J; Wang LY; Stamford AW; Kennedy ME; Kuvelkar R; Chen X; Parker EM; Strickland C; Voigt J
    Bioorg Med Chem Lett; 2008 Jan; 18(1):414-7. PubMed ID: 18023580
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason.
    Hills ID; Holloway MK; de León P; Nomland A; Zhu H; Rajapakse H; Allison TJ; Munshi SK; Colussi D; Pietrak BL; Toolan D; Haugabook SJ; Graham SL; Stachel SJ
    Bioorg Med Chem Lett; 2009 Sep; 19(17):4993-5. PubMed ID: 19640712
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Why does beta-secretase zymogen possess catalytic activity? Molecular modeling and molecular dynamics simulation studies.
    Zuo Z; Gang C; Zou H; Mok PC; Zhu W; Chen K; Jiang H
    Comput Biol Chem; 2007 Jun; 31(3):186-95. PubMed ID: 17500040
    [TBL] [Abstract][Full Text] [Related]  

  • 18. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
    Meredith JE; Thompson LA; Toyn JH; Marcin L; Barten DM; Marcinkeviciene J; Kopcho L; Kim Y; Lin A; Guss V; Burton C; Iben L; Polson C; Cantone J; Ford M; Drexler D; Fiedler T; Lentz KA; Grace JE; Kolb J; Corsa J; Pierdomenico M; Jones K; Olson RE; Macor JE; Albright CF
    J Pharmacol Exp Ther; 2008 Aug; 326(2):502-13. PubMed ID: 18499745
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rational design and synthesis of potent dibenzazepine motifs as beta-secretase inhibitors.
    Al-Tel TH; Al-Qawasmeh RA; Schmidt MF; Al-Aboudi A; Rao SN; Sabri SS; Voelter W
    J Med Chem; 2009 Oct; 52(20):6484-8. PubMed ID: 19788239
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
    Yang W; Lu W; Lu Y; Zhong M; Sun J; Thomas AE; Wilkinson JM; Fucini RV; Lam M; Randal M; Shi XP; Jacobs JW; McDowell RS; Gordon EM; Ballinger MD
    J Med Chem; 2006 Feb; 49(3):839-42. PubMed ID: 16451048
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.